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General Information
Symbol
Dmel\Nup15401501
Species
D. melanogaster
Name
FlyBase ID
FBal0007979
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)01501
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{PZ} insertion approximately 100bp upstream from the start of the predicted Nup154 open reading frame. The insertion is in the opposite 5' to 3' orientation to the direction of Nup154 transcription.

Insertion components
P{PZ}Nup15401501
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Nup15401501/Nup154RV5 males have a "meiotic arrest" phenotype in the testis; early spermatogenic stages appear normal and spermatocytes accumulate, but cells in meiotic divisions and spermatid differentiation are lacking. Larvae transheterozygous for Nup15401501 and either Nup1542 or Nup154k08204 die throughout the early larval stages, with survivors found until only just after the third instar larval moult. Until the end of the second instar stage, the larvae appear morphologically similar to their heterozygous siblings in body and tissue size. After the third instar moult, the larvae fail to grow and show a "classic mitotic mutant" phenotype, including reduced overall body size and a reduction in the size of larval organs that normally contain proliferating cells. Homozygous, hemizygous or transheterozygous third instar larvae have smaller brains than their age-matched control siblings. Although the neuropil is relatively normal in size, the optic lobes are greatly reduced and imaginal discs are tiny and difficult if not impossible to locate. The lymph glands are also reduced in size in third instar larvae.

Nup154tlp2/Nup15401501 ovarioles have a "string of pearls" morphology in which egg chambers have degenerated before entering vitellogenic stages.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Nup15401501/Nup154[+] is a suppressor of visible | somatic clone phenotype of wgAct5C.PS

Phenotype Manifest In
Suppressor of
Statement
Reference

Nup15401501/Nup154[+] is a suppressor of leg | somatic clone phenotype of wgAct5C.PS

Nup15401501/Nup154[+] is a suppressor of wing | ectopic | somatic clone phenotype of wgAct5C.PS

Additional Comments
Genetic Interactions
Statement
Reference

The frequency of leg-to-wing transdetermination caused by expression of wgAct5C.PS in clones during the mid-second larval instar is dominantly suppressed by Nup15401501.

Nup15401501 cup8 double heterozygous females show no obvious defects in egg chamber development.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Excision of the P{PZ} element results in viable, fertile flies.

After six generations of outcrossing the lethality continued to segragate with the P{PZ} insertion.

Complements: l(2)0400804008. Complements: cmet04431. Complements: l(2)0622506225. Complements: l(2)k05812k05812. Complements: l(2)k09104k09104. Complements: RfC38k13807. Complements: SCARk13811. Complements: l(2)k15817k15817.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)