FlyBase Allele Report: Dmel\Nipped-B[02047]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\Nipped-B⁰²⁰⁴⁷

General Information

Symbol

Dmel\Nipped-B⁰²⁰⁴⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0007991

Feature type

allele

Associated gene

Associated Insertion(s)

P{PZ}Nipped-B⁰²⁰⁴⁷

Carried in Construct

Also Known As

l(2)02047

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}Nipped-B⁰²⁰⁴⁷

Cytology

Description

P{PZ} is inserted into an intron of Nipped-B.

(Rollins et al., 1999)

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle (with Nipped-B^NC6)

(Gause et al., 2008)

abnormal mitotic cell cycle (with Nipped-B^NC7)

(Gause et al., 2008)

abnormal mitotic cell cycle (with Nipped-B^NC23)

(Gause et al., 2008)

abnormal mitotic cell cycle (with Nipped-B^NC39)

(Gause et al., 2008)

abnormal mitotic cell cycle (with Nipped-B^NC41)

(Gause et al., 2008)

abnormal mitotic cell cycle (with Nipped-B^NC59)

(Gause et al., 2008)

abnormal mitotic cell cycle (with Nipped-B^NC71)

(Gause et al., 2008)

abnormal mitotic cell cycle (with Nipped-B^NC77)

(Gause et al., 2008)

abnormal mitotic cell cycle (with Nipped-B^NC78)

(Gause et al., 2008)

lethal (with Df(2R)M41A2)

(Coulthard et al., 2010)

lethal (with Nipped-B^34-3)

(Coulthard et al., 2010)

lethal (with Nipped-B^45-53)

(Coulthard et al., 2010)

lethal (with Nipped-B^292.1)

(Coulthard et al., 2010)

lethal (with Nipped-B⁴⁰⁷)

(Coulthard et al., 2010)

lethal (with Nipped-B^ch(2)54)

(Coulthard et al., 2010)

lethal (with Nipped-B^IR13)

(Coulthard et al., 2010)

lethal (with Nipped-B^k02601a)

(Coulthard et al., 2010)

lethal (with Nipped-B^L5)

(Coulthard et al., 2010)

lethal (with Nipped-B^L7)

(Coulthard et al., 2010)

lethal (with Nipped-B^La6)

(Coulthard et al., 2010)

lethal (with Nipped-B^Lf)

(Coulthard et al., 2010)

lethal (with Nipped-B^LL)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC6)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC7)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC23)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC39)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC41)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC59)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC60)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC71)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC77)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC78)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC91)

(Coulthard et al., 2010)

lethal (with Nipped-B^NC138)

(Coulthard et al., 2010)

lethal | recessive

(Corradini et al., 2003, Rollins et al., 1999, Spradling et al., 1999, Jackle and Janning, 1998.8.10)

Phenotype Manifest In

Detailed Description

Statement

Reference

Neuroblast metaphase nuclei show precocious sister chromatid separation in animals heteroallelic for Nipped-B⁰²⁰⁴⁷ and Nipped-B^NC6, Nipped-B^NC7, Nipped-B^NC23, Nipped-B^NC39, Nipped-B^NC41, Nipped-B^NC59, Nipped-B^NC71, Nipped-B^NC77 or Nipped-B^NC78.

(Gause et al., 2008)

Approximately 60% of metaphase nuclei in the brains of Nipped-B⁴⁰⁷/Nipped-B⁰²⁰⁴⁷ second instar larvae show precocious sister chromatid separation, in which the centromeric regions of the sister chromatids are somewhat detached from each other.

50% of metaphase nuclei in the brains of Nipped-B^292.1/Nipped-B⁰²⁰⁴⁷ and Nipped-B⁰²⁰⁴⁷ homozygous second instar larvae show precocious sister chromatid separation, in which the centromeric regions of the sister chromatids are somewhat detached from each other.

(Rollins et al., 2004)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

(Rollins et al., 1999)

(Rollins et al., 1999)

Nipped-B⁴⁰⁷

(Rollins et al., 1999)

(Rollins et al., 1999)

Nipped-B^k13422a

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

11143

P{PZ}Nipped-B⁰²⁰⁴⁷ cn¹/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Comments

"FBti0005207 == FBti0000286 == P{PZ}Nipped-B⁰²⁰⁴⁷" was stated as revision. 9 out of 13 excisions of the P{PZ} revert the Nipped-B mutant phenotype.

(Rollins et al., 1999)

Complements: tsh⁰⁴³¹⁹. Complements: vlc⁰⁷⁰²². Complements: l(2)k03002a^k03002a. Complements: l(2)k03002a^k04601a. Complements: l(2)k07312b^k07312b.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

2047

(Coulthard et al., 2010)

Nipped-B⁰²⁰⁴⁷

(Coulthard et al., 2010, Gambetta and Müller, 2009.8.18, Gause et al., 2008)

l(2)02047

(Rollins et al., 2004, Dimitri et al., 2003, Spradling et al., 1999)

l(2)02047⁰²⁰⁴⁷

(BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections