Allele Dmel\Hr38⁰²³⁰⁶

General Information
Symbol	Dmel\Hr38⁰²³⁰⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0007996
Feature type	allele	Associated gene	Dmel\Hr38
Also Known As	l(2)02306

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2L:20,714,623..20,714,624 2L:20,714,619..20,714,619 (BDGP Project Members, 1994-1999, Butler et al., 2001, Pokholkova et al., 1999, Kozlova et al., 1998, Spradling et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AJ001775

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{PZ} insertion 34bp upstream of the start of the Hr38 cTK61 isoform. (Pokholkova et al., 1999) P{PZ} insertion 8bp downstream of a potential TATA box for Hr38 and 17 bp upstream of a TCAGT motif commonly associated with transcription start sites. (Kozlova et al., 1998)
Caused by insertion	P{PZ}Hr38⁰²³⁰⁶ (BDGP Project Members, 1994-1999, Butler et al., 2001, Pokholkova et al., 1999, Kozlova et al., 1998, Spradling et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| adult stage \| recessive (Kozlova et al., 1998) lethal \| recessive (Pokholkova et al., 1999, Spradling et al., 1999) visible (Pokholkova et al., 1999)
Phenotype Manifest In
	adult cuticle (Pokholkova et al., 1999, Kozlova et al., 1998) adult epidermis (Kozlova et al., 1998) joint (Pokholkova et al., 1999)
Detailed Description
	Statement Reference Homozygotes show local fragility of the adult cuticle; the cuticle in the leg joints is ruptured by mechanical stress, leading to melanisation of the damaged spots. The flies subsequently die as pharate adults or within a few hours after eclosion. (Pokholkova et al., 1999) Eclosing adults appear initially normal but die within a few hours following rupture of the cuticle at joints. Ruptures become melanized. (Kozlova et al., 1998)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Hr38⁴³ (Kozlova et al., 1998) Hr38⁵⁶ (Kozlova et al., 1998) Hr38⁵⁷ (Kozlova et al., 1998)
Comments
Stocks ( 1 )
Bloomington	11181 P{PZ}Hr38⁰²³⁰⁶ cn¹/CyO; ry⁵⁰⁶
Notes on Origin
Discoverer	A. Spradling.

Comments
	Excision of the P{PZ} is accompanied by reversion of the mutant phenotype. (Kozlova et al., 1998) Complements: dia^k07135. Complements: dia^k07140. Complements: l(2)01528^k13715a. Complements: dpp^k17036a. Complements: dia¹. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Hr38⁰²³⁰⁶ l(2)02306 (Butler, 2001, Butler et al., 2001, Pokholkova et al., 1999, Spradling et al., 1999, Bruey-Sedano et al., 2005) l(2)02306⁰²³⁰⁶
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Bruey-Sedano et al., 2005, genesis 43(1): 17--27 The Drosophila ACP65A cuticle gene: deletion scanning analysis of cis-regulatory sequences and regulation by DHR38. [FBrf0188378] Butler et al., 2001, Genetics 158(4): 1597--1614 Map position and expression of the genes in the 38 region of Drosophila. [FBrf0138405] Pokholkova et al., 1999, D. I. S. 82: 56--58 Drosophila hormone receptor 38: phenotypic analysis of mutations generated by P-element excision. [FBrf0112007] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Kozlova et al., 1998, Genetics 149(3): 1465--1475 Drosophila hormone receptor 38 functions in metamorphosis. A role in adult cuticle formation. [FBrf0102956]
Supplementary material	Butler, 2001, Genetics 158(4): Supplemental Material 1. P-elements that map by in situ hybridization to cytological region 38. [FBrf0139852]
Personal communication to FlyBase	Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Abstract	Kozlova et al., 1998, A. Dros. Res. Conf. 39: 490A Drosophila hormone receptor 38 is required for adult cuticle formation during metamorphosis. [FBrf0101527]

Allele Dmel\Hr3802306

Allele Dmel\Hr38⁰²³⁰⁶