FB2025_01 , released February 20, 2025
Allele: Dmel\Hr3802306
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General Information
Symbol
Dmel\Hr3802306
Species
D. melanogaster
Name
FlyBase ID
FBal0007996
Feature type
allele
Associated gene
Dmel\Hr38
Associated Insertion(s)
P{PZ}Hr3802306
Carried in Construct
Also Known As
l(2)02306
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}Hr3802306
Cytology
Description

P{PZ} insertion 34bp upstream of the start of the Hr38 cTK61 isoform.

(Pokholkova et al., 1999)

P{PZ} insertion 8bp downstream of a potential TATA box for Hr38 and 17 bp upstream of a TCAGT motif commonly associated with transcription start sites.

(Kozlova et al., 1998)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ001775
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes show local fragility of the adult cuticle; the cuticle in the leg joints is ruptured by mechanical stress, leading to melanisation of the damaged spots. The flies subsequently die as pharate adults or within a few hours after eclosion.

      (Pokholkova et al., 1999)

      Eclosing adults appear initially normal but die within a few hours following rupture of the cuticle at joints. Ruptures become melanized.

      (Kozlova et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Excision of the P{PZ} is accompanied by reversion of the mutant phenotype.

      (Kozlova et al., 1998)

      Complements: diak07135. Complements: diak07140. Complements: l(2)01528k13715a. Complements: dppk17036a. Complements: dia1.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hr3802306
      (Clarembaux-Badell et al., 2022, Kahsai and Cook, 2018)
      l(2)02306
      (Bruey-Sedano et al., 2005, Butler, 2001, Butler et al., 2001, Pokholkova et al., 1999, Spradling et al., 1999)
      l(2)0230602306
      Name Synonyms
      Secondary FlyBase IDs
        References (12)