Allele Dmel\zip⁰²⁹⁵⁷

General Information
Symbol	Dmel\zip⁰²⁹⁵⁷	Species	D. melanogaster
Name		FlyBase ID	FBal0008010
Feature type	allele	Associated gene	Dmel\zip

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2R:20,898,241..20,898,241 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Baumann, 2004, Vereshchagina et al., 2004, Saja et al., 2010)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{PZ}zip⁰²⁹⁵⁷ (BDGP Project Members, 1994-1999, Spradling et al., 1999, Baumann, 2004, Vereshchagina et al., 2004, Saja et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Spradling et al., 1999, Perrimon et al., 1996) visible (with zip^Ebr) (Mizuno et al., 2002)
Phenotype Manifest In
	embryonic/first instar larval cuticle \| dorsal (Perrimon et al., 1996) eye (with zip^Ebr) (Baumann, 2004) pigment cell (with zip^Ebr) (Baumann, 2004) retina (with zip^Ebr) (Baumann, 2004) rhabdomere (with zip^Ebr) (Baumann, 2004) wing (with zip^Ebr) (Baumann, 2004, Mizuno et al., 2002)
Detailed Description
	Statement Reference About 70% of zip^Ebr/zip⁰²⁹⁵⁷ adults have malformed wings. (Mizuno et al., 2002) Some cells in homozygous clones in the wing have multiple F-actin prehairs. (Winter et al., 2001) Germline clones produce eggs with patterning defects: dorsal closure is defective. Lethality occurs during the embryonic and larval stages. (Perrimon et al., 1996)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference zip⁰²⁹⁵⁷/zip^Ebr has visible phenotype, suppressible \| partially by Mbs³/Mbs[+] (Mizuno et al., 2002)
Enhancer of
Statement Reference zip[+]/zip⁰²⁹⁵⁷ is an enhancer of neuroanatomy defective phenotype of Ppt1^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Saja et al., 2010) zip⁰²⁹⁵⁷ is an enhancer of cell polarity defective phenotype of S^48-5 (Gaengel and Mlodzik, 2003)
Suppressor of
Statement Reference zip⁰²⁹⁵⁷ is a suppressor of lethal \| male phenotype of flw⁶ (Vereshchagina et al., 2004) zip⁰²⁹⁵⁷ is a suppressor of lethal \| male phenotype of flw^G0172/flw^G0172 (Vereshchagina et al., 2004)
Phenotype Manifest In
Suppressed by
Statement Reference zip⁰²⁹⁵⁷/zip^Ebr has wing phenotype, suppressible \| partially by Mbs³/Mbs[+] (Mizuno et al., 2002)
Enhancer of
Statement Reference zip[+]/zip⁰²⁹⁵⁷ is an enhancer of eye phenotype of Ppt1^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Saja et al., 2010) zip⁰²⁹⁵⁷ is an enhancer of ommatidium phenotype of S^48-5 (Gaengel and Mlodzik, 2003)
Additional Comments
Genetic Interactions
Statement Reference A zip[02957]/+ background enhances the visual system degeneration seen in Scer\GAL4[GMR.PF], Ppt1[Scer\UAS.cKa] flies. (Saja et al., 2010) S^48-5/zip⁰²⁹⁵⁷ mutants show 34.60%+-4.71 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. (Gaengel and Mlodzik, 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	zip^k15609 (BDGP Project Members, 1994-1999)
Comments
Stocks ( 1 )
Bloomington	11215 cn¹ P{PZ}zip⁰²⁹⁵⁷/CyO; ry⁵⁰⁶
Notes on Origin
Discoverer	A. Spradling.

Comments
	Complements: l(2)00064⁰⁰⁰⁶⁴. Complements: Kr⁰⁰⁸⁹⁵. Complements: l(2)01848⁰¹⁸⁴⁸. Complements: l(2)10481⁰³²⁶³. Complements: Kr^k05826. Complements: mts^k12502. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	l(2)02957 (Spradling et al., 1999) l(2)02957⁰²⁹⁵⁷ zip-02957 (Gaengel and Mlodzik, 2003) zip⁰²⁹⁵⁷
Name Synonym
Secondary FlyBase IDs

References ( 11 )
Research paper	Saja et al., 2010, Neurobiol. Disease 40(1): 135--145 Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. [FBrf0211567] Baumann, 2004, Dev. Biol. 269(2): 519--533 Spatial pattern of nonmuscle myosin-II distribution during the development of the Drosophila compound eye and implications for retinal morphogenesis. [FBrf0174531] Vereshchagina et al., 2004, Mol. Biol. Cell 15(10): 4395--4405 the essential role of PP1beta in Drosophila is to regulate nonmuscle myosin. [FBrf0180501] Gaengel and Mlodzik, 2003, Development 130(22): 5413--5423 Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6. [FBrf0167499] Mizuno et al., 2002, Development 129(5): 1215--1223 Drosophila myosin phosphatase and its role in dorsal closure. [FBrf0144821] Winter et al., 2001, Cell 105(1): 81--91 Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. [FBrf0135688] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Perrimon et al., 1996, Genetics 144(4): 1681--1692 Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. [FBrf0091142]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\zip02957

Allele Dmel\zip⁰²⁹⁵⁷