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General Information
Symbol
Dmel\sbb04440
Species
D. melanogaster
Name
FlyBase ID
FBal0008061
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)04440
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{lacW} insertion is within intron 1.

Insertion components
P{PZ}sbb04440
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

photoreceptor cell R1 & axon | somatic clone (with sbb1)

photoreceptor cell R1 & axon | somatic clone (with sbb2)

photoreceptor cell R1 & neuron

photoreceptor cell R2 & axon | somatic clone (with sbb1)

photoreceptor cell R2 & axon | somatic clone (with sbb2)

photoreceptor cell R2 & neuron

photoreceptor cell R3 & axon | somatic clone (with sbb1)

photoreceptor cell R3 & axon | somatic clone (with sbb2)

photoreceptor cell R3 & neuron

photoreceptor cell R4 & axon | somatic clone (with sbb1)

photoreceptor cell R4 & axon | somatic clone (with sbb2)

photoreceptor cell R4 & neuron

photoreceptor cell R5 & axon | somatic clone (with sbb1)

photoreceptor cell R5 & axon | somatic clone (with sbb2)

photoreceptor cell R5 & neuron

photoreceptor cell R6 & axon | somatic clone (with sbb1)

photoreceptor cell R6 & axon | somatic clone (with sbb2)

photoreceptor cell R6 & neuron

Detailed Description
Statement
Reference

Third instar larvae homozygous for sbb04440 displays a significant increase in turning rate during crawling, as compared to controls.

In contrast to the wild-type, in mutant larvae, the lamina plexus is discontinuous. Thick bundles of axons are frequently observed between the lamina and the medulla, in striking contrast to the thin bundles in wild-type. In the most severe cases, the lamina plexus is largely missing and the medulla neuropil is hyperinnervated. In addition, disruptions in the normally smooth topographic map in then medulla are observed. However R-cell projections do not extend through the medulla into deeper layers of the optic lobe, suggesting that R8 neurons terminate, as in wild-type, within the medulla neuropil.

R1-R6 photoreceptor axons overshoot their targets in sbb1/sbb04440 or sbb2/sbb04440 transheterozygous larvae.

Homozygous larvae show significantly more turning behaviour on non-nutritive agar than wild-type larvae ("scribbler" behaviour).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

sbb[+]/sbb04440 is an enhancer of wing vein | ectopic phenotype of Snr1E1

NOT Enhancer of
Statement
Reference

sbb04440 is a non-enhancer of phenotype of Mer3

NOT Suppressor of
Statement
Reference

sbb04440 is a non-suppressor of phenotype of Mer3

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Phenotypic analysis suggests an allelic series: sbb4 >= sbbk06903b > sbb5 = sbbk00702 > sbb04440.

Complements: l(2)0877002302. Complements: Hsf03091. Complements: l(2)0454804548. Complements: Prp1907838. Complements: lolalk02512. Complements: l(2)08770k04808. Complements: pAbpk10109. Complements: Pcls1859.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (14)