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General Information
Symbol
Dmel\Lamsz18
Species
D. melanogaster
Name
FlyBase ID
FBal0008356
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
misgsz18, jf27sz18, laminsz18
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Lamsz18 is a suppressor of both bw[VDE2]/In(2R)bwVDe2 and bw[D]/Dp(?;2)bwD position effect variegation and is an enhancer of centromeric and heterochromatic (e.g. w[m4]/In(1)wm4) position effect variegation, but has not effect on telomeric position effect variegation
The majority of Lamsz18/Df(2L)GpdhA mutants die at the pharate adult stage and the rest die throughout the pupal stage. Under 3% of these mutants eclose; such animals have severe defects in walking and flying and die within a few days.
19% of homozygous embryos show misguided and stalled terminal tracheal branches at 25oC. Egg chambers of females containing homozygous germline clones show severe nuclear disorganisation and no eggs are produced.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Other
Statement
Reference
Lamsz18, hbhs.PS has U1 neuron | ectopic | heat sensitive phenotype
Lamsz18, hbhs.PS has U2 neuron | ectopic | heat sensitive phenotype
Additional Comments
Genetic Interactions
Statement
Reference
Expression of hbhs.PS using brief heat shock late in the competence window for NB7-1 neuroblasts to make U1/U2 neurons results in a significant increase in the percentage of NB7-1 lineages with ectopic hb[+] U1/U2 neurons if expression is in a Lamsz18 background compared to expression in a wild-type background.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)