is a suppressor of both bw[VDE2]/In(2R)bwVDe2
position effect variegation and is an enhancer of centromeric and heterochromatic (e.g. w[m4]/In(1)wm4
) position effect variegation, but has not effect on telomeric position effect variegation
The majority of Lamsz18
mutants die at the pharate adult stage and the rest die throughout the pupal stage. Under 3% of these mutants eclose; such animals have severe defects in walking and flying and die within a few days.
19% of homozygous embryos show misguided and stalled terminal tracheal branches at 25oC. Egg chambers of females containing homozygous germline clones show severe nuclear disorganisation and no eggs are produced.