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General Information
Symbol
Dmel\Arpc11
Species
D. melanogaster
Name
FlyBase ID
FBal0008422
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)34DdCH60, Arpc1CH60
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Reported as a 207bp genomic deletion that removes the last 62 codons of Arpc1 . Exact boundaries not reported.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Contains a 207-bp genomic deletion that removes the last 62 codons of Arpc1.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Cultured primary neurons derived from Sop21 and Sop21/Sop2Q25sd embryos show a significant reduction in the number of filopodia compared to control neurons.

Sop23 produces about 1% escapers in heterozygous combination with both Sop21 and Sop22.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Enhancer of
Statement
Reference
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Cultured primary neurons derived from DAAMEx1/DAAMEx68 Sop21 embryos show a very strong reduction in the number of filopodia (to 5% of the wild type average) compared to control neurons.

Only 20% of cultured primary neurons derived from DAAMEx1/DAAMEx68 Sop21/Sop2Q25sd embryos have neurites.

Cultured primary neurons derived from DAAMEx68/+ Sop21/+ and Sop21/+ ena23/+ double heterozygous embryos show a significant reduction in the number of filopodia compared to control neurons.

Cultured primary neurons derived from Sop21/+ chic221/+ double heterozygous embryos have a normal number of filopodia.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (8)