FB2021_02, released April 13, 2021

Allele: Dmel\Arpc11

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General Information
Symbol
Dmel\Arpc11
Species
D. melanogaster
Name
FlyBase ID
FBal0008422
Feature type
allele
Associated gene
Dmel\Arpc1
Associated Insertion(s)
Carried in Construct
Also Known As
l(2)34DdCH60, Arpc1CH60
Key Links
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
2L:13,828,195..13,828,401 [-]
Comment:

Reported as a 207bp genomic deletion that removes the last 62 codons of Arpc1 . Exact boundaries not reported.

(Hudson and Cooley, 2002)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Contains a 207-bp genomic deletion that removes the last 62 codons of Arpc1.

      (Hudson and Cooley, 2002)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cultured primary neurons derived from Sop21 and Sop21/Sop2Q25sd embryos show a significant reduction in the number of filopodia compared to control neurons.

      (Gonçalves-Pimentel et al., 2011)

      Sop23 produces about 1% escapers in heterozygous combination with both Sop21 and Sop22.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Arpc11 has filopodium phenotype, enhanceable by DAAMEx1/DAAMEx68

      (Gonçalves-Pimentel et al., 2011)
      Enhancer of
      Statement
      Reference

      Arpc11 is an enhancer of filopodium phenotype of DAAMEx1/DAAMEx68

      (Gonçalves-Pimentel et al., 2011)
      Other
      Statement
      Reference

      Arpc11, ena23/ena[+] has filopodium phenotype

      (Gonçalves-Pimentel et al., 2011)

      DAAMEx68, Sop2[+]/Arpc11 has filopodium phenotype

      (Gonçalves-Pimentel et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Cultured primary neurons derived from DAAMEx1/DAAMEx68 Sop21 embryos show a very strong reduction in the number of filopodia (to 5% of the wild type average) compared to control neurons.

      Only 20% of cultured primary neurons derived from DAAMEx1/DAAMEx68 Sop21/Sop2Q25sd embryos have neurites.

      Cultured primary neurons derived from DAAMEx68/+ Sop21/+ and Sop21/+ ena23/+ double heterozygous embryos show a significant reduction in the number of filopodia compared to control neurons.

      Cultured primary neurons derived from Sop21/+ chic221/+ double heterozygous embryos have a normal number of filopodia.

      (Gonçalves-Pimentel et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      O'Donnell.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      References (8)