FlyBase Allele Report: Dmel\CycE[05206]

(Jagut et al., 2013, Geng and MacDonald, 2007, Doronkin et al., 2003, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999, Duronio et al., 1998, Stroumbakis et al., 1996, BDGP Project Members, 1994-1999, Knoblich et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tuberous sclerosis

modeled by Tsc1^UAS.cTa, gig^UAS.cTa

(Tapon et al., 2001)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | embryonic stage (with CycE²)

(Duronio et al., 1998)

lethal (with CycE^1F36)

(Unhavaithaya et al., 2013)

lethal (with CycE^10.73)

(Unhavaithaya et al., 2013)

lethal (with CycE^22t)

(Unhavaithaya et al., 2013)

lethal (with CycE^32-8)

(Unhavaithaya et al., 2013)

lethal (with CycE^B29-25l)

(Unhavaithaya et al., 2013)

lethal | recessive

(Ashburner et al., 1999, Spradling et al., 1999, Roote, 1995.5.15, Knoblich et al., 1994)

lethal - all die before end of larval stage | recessive

(Royzman et al., 1997)

partially lethal - majority die (with CycE²)

(Duronio et al., 1998)

some die during larval stage | recessive

(Royzman et al., 1997)

sterile (with CycE²)

(Duronio et al., 1998)

viable

(Prokopenko and Bellen, 1997.1.7)

visible | adult stage (with CycE²)

(Duronio et al., 1998)

visible | recessive

(Prokopenko and Bellen, 1997.1.7)

Phenotype Manifest In

anterior midgut primordium | embryonic stage (with CycE²)

(Duronio et al., 1998)

egg chorion | unfertilized egg stage

(Royzman et al., 1997)

eye

(Prokopenko and Bellen, 1997.1.7)

eye (with CycE²)

(Duronio et al., 1998)

eye (with CycE^k02514)

(Prokopenko et al., 2000)

ommatidium (with CycE^k02514)

(Prokopenko et al., 2000)

wing vein

(Prokopenko and Bellen, 1997.1.7)

wing vein (with CycE^k02514)

(Prokopenko et al., 2000)

wing vein L5 | adult stage (with CycE²)

(Duronio et al., 1998)

Detailed Description

Statement

Reference

CycE^k02514/CycE⁰⁵²⁰⁶ adult escapers are viable, but have rough eyes and wing venation defects.

(Prokopenko et al., 2000)

CycE⁰⁵²⁰⁶ in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces no viable flies.

(Sawamura et al., 2000)

No BrdU incorporation is detected in the anterior midgut cells of stage 13 CycE⁰⁵²⁰⁶/CycE² embryos. However, at stage 14 some BrdU incorporation is detected in these cells. This suggests the G₁-S transition is delayed. 3.7% of CycE⁰⁵²⁰⁶/CycE² animals eclose. These flies are sterile, have rough eyes and the fifth wing vein is incompletely formed.

(Duronio et al., 1998)

Flies transheterozygous for CycE⁰⁵²⁰⁶ and CycE^k02514 are viable but have rough eyes and wing venation defects.

(Prokopenko and Bellen, 1997.1.7)

DNA replication is not detected in the endodomains of homozygous embryos.

(Royzman et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

CycE[+]/CycE⁰⁵²⁰⁶ is an enhancer of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

CycE⁰⁵²⁰⁶ is an enhancer of abnormal mitotic cell cycle | maternal effect phenotype of png¹⁰⁵⁸/png³³¹⁸

(Lee et al., 2001)

CycE⁰⁵²⁰⁶ is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^ey.PH, Tsc1^UAS.cTa, gig^UAS.cTa

(Tapon et al., 2001)

CycE⁰⁵²⁰⁶ is an enhancer of visible | adult stage phenotype of Scer\GAL4^ey.PH, Tsc1^UAS.cTa, gig^UAS.cTa

(Tapon et al., 2001)

CycE[+]/CycE⁰⁵²⁰⁶ is an enhancer of lethal phenotype of E2f1ⁱ¹/E2f1⁹¹

(Royzman et al., 1999)

CycE[+]/CycE⁰⁵²⁰⁶ is an enhancer | maternal effect of lethal phenotype of E2f1⁹¹/E2f1⁰⁷¹⁷²

(Royzman et al., 1997)

NOT Enhancer of

Statement

Reference

CycE⁰⁵²⁰⁶ is a non-enhancer of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Suppressor of

Statement

Reference

CycE[+]/CycE⁰⁵²⁰⁶ is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

CycE[+]/CycE⁰⁵²⁰⁶ is a suppressor of partially lethal - majority die | dominant | heat sensitive phenotype of hop^Tum

(Chen et al., 2003)

CycE[+]/CycE⁰⁵²⁰⁶ is a suppressor of increased cell number | oogenesis phenotype of CSN5^L4032/CSN5^ex21

(Doronkin et al., 2003)

NOT Suppressor of

Statement

Reference

CycE[+]/CycE⁰⁵²⁰⁶ is a non-suppressor of increased cell death phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycE⁰⁵²⁰⁶ is a non-suppressor of visible phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Other

Statement

Reference

CycD¹, CycE[+]/CycE⁰⁵²⁰⁶ has lethal phenotype

(Emmerich et al., 2004)

CycD², CycE[+]/CycE⁰⁵²⁰⁶ has lethal phenotype

(Emmerich et al., 2004)

CycD², CycE⁰⁵²⁰⁶ has lethal | dominant phenotype

(Emmerich et al., 2004)

CycD¹, CycE⁰⁵²⁰⁶ has lethal | dominant phenotype

(Emmerich et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

CycE[+]/CycE⁰⁵²⁰⁶ is an enhancer of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

CycE[+]/CycE⁰⁵²⁰⁶ is an enhancer of egg phenotype of Imp^UAS.cGa, Scer\GAL4^{VP16.mat.αTub67C}

(Geng and MacDonald, 2007)

CycE[+]/CycE⁰⁵²⁰⁶ is an enhancer of egg chorion phenotype of Imp^UAS.cGa, Scer\GAL4^{VP16.mat.αTub67C}

(Geng and MacDonald, 2007)

NOT Enhancer of

Statement

Reference

CycE⁰⁵²⁰⁶ is a non-enhancer of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Suppressor of

Statement

Reference

CycE[+]/CycE⁰⁵²⁰⁶ is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

CycE[+]/CycE⁰⁵²⁰⁶ is a suppressor | partially of nurse cell phenotype of CSN5^L4032/CSN5^ex21

(Doronkin et al., 2003)

CycE[+]/CycE⁰⁵²⁰⁶ is a suppressor | partially of nurse cell phenotype of CSN5^L4032/CSN5^ex13

(Doronkin et al., 2003)

NOT Suppressor of

Statement

Reference

CycE[+]/CycE⁰⁵²⁰⁶ is a non-suppressor of eye phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycE[+]/CycE⁰⁵²⁰⁶ is a non-suppressor of ommatidium phenotype of shtd¹

(Tanaka-Matakatsu et al., 2007)

CycE⁰⁵²⁰⁶ is a non-suppressor of eye phenotype of upd1^GMR.PB

(Mukherjee et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

A heterozygous CycE⁰⁵²⁰⁶ background strongly enhances the dorsalisation phenotype seen when Imp^Scer\UAS.cGa is expressed under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} (on the second).

(Geng and MacDonald, 2007)

Adult viability of CycD¹/Y ; CycE⁰⁵²⁰⁶/+ males is only 61% of expected value. Adult viability of CycD²/Y ; CycE⁰⁵²⁰⁶/+ males is only 46% of expected value.

(Emmerich et al., 2004)

Survival to adulthood of hop^Tum/+ females raised at 29^oC is restored to 85% of wild-type levels by heterozygosity for CycE⁰⁵²⁰⁶.

(Chen et al., 2003)

The number of egg chambers with twice the normal number of germ cells in CSN5^ex21/CSN5^L4032 flies, is reduced to 3.4% by CycE⁰⁵²⁰⁶/+ (n>500).

(Doronkin et al., 2003)

Expression of both Tsc1^Scer\UAS.cTa and gig^Scer\UAS.cTa in the eye under the control of Scer\GAL4^ey.PH results in a much smaller eye than normal. Addition of one copy of CycE⁰⁵²⁰⁶ enhances the phenotype.

(Tapon et al., 2001)

One copy of CycE⁰⁵²⁰⁶ has no effect on the viability of E2fⁱ²/E2f⁹¹ flies. One copy of CycE⁰⁵²⁰⁶ enhances the lethality of E2fⁱ¹/E2f⁹¹ flies; no adults are recovered.

(Royzman et al., 1999)

Lethality of E2f1⁹¹/E2f1⁰⁷¹⁷² transheterozygotes is dramatically enhanced by reducing the maternal dosage of CycE (CycE⁰⁵²⁰⁶).

(Royzman et al., 1997)

Xenogenetic Interactions

Statement

Reference

One copy of CycE⁰⁵²⁰⁶ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Complements

CycE^k05002a

(Prokopenko et al., 2000)

Fails to complement

CycE^k02514

(Prokopenko et al., 2000)

CycE¹⁰⁴²⁷

(BDGP Project Members, 1994-1999)

CycE⁰⁵²⁷⁸

(BDGP Project Members, 1994-1999)

CycE⁰⁵²⁷⁷

(BDGP Project Members, 1994-1999)

CycE^k02602

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11396

P{PZ}CycE⁰⁵²⁰⁶ cn¹/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

(Roote, 1995.5.4)

G. Karpen and A. Spradling.

(Knoblich et al., 1994)

Comments

Complements: wek^05271a. Complements: CG15269⁰⁵⁴⁴¹. Complements: esg⁰⁵⁷³⁰. Complements: gft⁰⁶⁴³⁰. Complements: esg⁰⁷⁰⁸². Complements: esg^k06211.

(BDGP Project Members, 1994-1999)

Reverts to viability with P element transposase.

(Knoblich et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

05206

(Mukherjee et al., 2006)

Cyc^E05206

(Jagut et al., 2013)

CycE⁰⁵²⁰⁶

(Unhavaithaya et al., 2013, Ambegaokar and Jackson, 2011, Christensen and Cook, 2007.3.22, Tanaka-Matakatsu et al., 2007)

CycE^PZ05206

(Sawamura et al., 2000)

CycE^PZ5

(Emmerich et al., 2004, Tapon et al., 2001, Royzman et al., 1999)

CycE^pz5

(Althoff et al., 2009)

PZ05206

(Ashburner et al., 1999)

PZ5

(Stroumbakis et al., 1996)

cyclin E^PZ5

(Whittaker et al., 2000, Royzman et al., 1997)

cyclinE⁵²⁰⁶

(Duronio et al., 1998)

l(2)05206

(Lee et al., 2001, Spradling et al., 1999)

l(2)35Dd^PZ5

(Roote, 1995.5.15, Knoblich et al., 1994)

Name Synonyms

Secondary FlyBase IDs

References (35)

Report Sections

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