Most heixk11403/Df(2L)RA5 and heixk11403/heix1 flies produce melanotic masses in larval or pupal stage. Mutant larvae present an enormous overgrowth of the lymph gland. This event is coupled with a dramatic increase of circulating hemocytes and an aberrant differentiation of lamellocytes. The size of primary lobes in heixk11403/Df(2L)RA5 and heixk11403/heix1 mutant lymph glands is about two times and four times larger than that in the control, respectively; the size of secondary lobes in heixk11403/Df(2L)RA5 flies is about five times larger, and in heixk11403/heix1 third instar larvae, they are approximately twenty times larger than that observed in controls.
Primary and secondary lobes in heixk11403/Df(2L)RA5 lymph glands lose their architectural structure.
The lymph glands and fat body of heixk11403/Df(2L)RA5 third instar larvae show a mitochondria morphological defect.
Feeding hemizygous animals with the MK-4 form of vitamin K[], but not with menadione (a synthetic precursor that is prenylated to form vitamin K[]) or with ubiquinone significantly improves their survival rate.