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General Information
Symbol
Dmel\heixk11403
Species
D. melanogaster
Name
FlyBase ID
FBal0008538
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
k11403
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Inserted in the 5' UTR of the heix transcript.
Insertion components
P{lacW}heixk11403
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Most heixk11403/Df(2L)RA5 and heixk11403/heix1 flies produce melanotic masses in larval or pupal stage. Mutant larvae present an enormous overgrowth of the lymph gland. This event is coupled with a dramatic increase of circulating hemocytes and an aberrant differentiation of lamellocytes. The size of primary lobes in heixk11403/Df(2L)RA5 and heixk11403/heix1 mutant lymph glands is about two times and four times larger than that in the control, respectively; the size of secondary lobes in heixk11403/Df(2L)RA5 flies is about five times larger, and in heixk11403/heix1 third instar larvae, they are approximately twenty times larger than that observed in controls. Primary and secondary lobes in heixk11403/Df(2L)RA5 lymph glands lose their architectural structure. The lymph glands and fat body of heixk11403/Df(2L)RA5 third instar larvae show a mitochondria morphological defect.
Feeding hemizygous animals with the MK-4 form of vitamin K[[2]], but not with menadione (a synthetic precursor that is prenylated to form vitamin K[[2]]) or with ubiquinone significantly improves their survival rate.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
heixk11403/heix[+] is an enhancer of flight defective phenotype of Pink1B9
heixk11403/heix[+] is an enhancer of visible | heat sensitive phenotype of HC2.hs
NOT Enhancer of
Statement
Reference
heixk11403/heix[+] is a non-enhancer of lethal | embryonic stage | partially | recessive phenotype of peb308
Suppressor of
Statement
Reference
heixk11403/heix[+] is a suppressor of visible | heat sensitive phenotype of peb1
NOT Suppressor of
Statement
Reference
heixk11403/heix[+] is a non-suppressor of lethal | embryonic stage | partially | recessive phenotype of peb308
Phenotype Manifest In
Enhancer of
Statement
Reference
heixk11403/heix[+] is an enhancer of wing vein | ectopic | heat sensitive phenotype of HC2.hs
heixk11403/heix[+] is an enhancer of wing | heat sensitive phenotype of HC2.hs
Suppressor of
Statement
Reference
heixk11403/heix[+] is a suppressor of eye | heat sensitive phenotype of peb1
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Phenotypes of lethality, lymph gland overgrowth, circulating hemocytes increase and aberrant differentiation that appear in heixk11403/Df(2L)RA5 flies are efficiently rescued by heixScer\UAS.cVa expression under the control of Scer\GAL4αTub84B.PL - the majority of these flies survive and are fertile.
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
I. Kiss.
Comments
Comments
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)