FlyBase Allele Report: Dmel\swm[37Dh-1]

General Information

Symbol

Dmel\swm^37Dh-1

Species

D. melanogaster

Name

FlyBase ID

FBal0008871

Feature type

allele

Associated gene

Dmel\swm

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wright et al., 1976)

Progenitor genotype

Cytology

Description

157bp deletion in exon 4, which shifts the reading frame at amino acid residue S249.

(Casso et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:19,494,782..19,494,938 [+]

Comment:

Approximate location of 157bp deletion reported at S249.

(Casso et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell size (with swm^F15)

(Casso et al., 2008)

lethal

(Casso et al., 2008)

lethal (with Df(2L)ED1272)

(Kahsai and Cook, 2018)

lethal | recessive

(Wright et al., 1976)

lethal - all die before end of larval stage (with swm^F15)

(Casso et al., 2008)

some die during larval stage (with swm^F15)

(Casso et al., 2008)

Phenotype Manifest In

wing (with swm^F15)

(Casso et al., 2008)

wing hair (with swm^F15)

(Casso et al., 2008)

Detailed Description

Statement

Reference

swm^F15/swm^37Dh-1 adult escapers have an increased distance between veins 3 and 4 in the wing compared to controls and 76% of the wings have patches of wing hairs that show abnormal orientation.

(Casso et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

swm^37Dh-1/swm[+] is an enhancer of visible | dominant phenotype of hh^Mrt

(Casso et al., 2008)

Suppressor of

Statement

Reference

swm^37Dh-1/swm[+] is a suppressor of visible phenotype of Scer\GAL4^ptc-559.1, smo^RNAi.UAS.WIZ

(Casso et al., 2008)

Scer\GAL4^C-765/swm^37Dh-1 is a suppressor | partially of visible phenotype of Scer\GAL4^C-765, smo^{5A.UAS.Tag:FLAG}

(Casso et al., 2008)

swm^37Dh-1 is a suppressor of visible phenotype of rux¹

(Casso et al., 2008)

NOT Suppressor of

Statement

Reference

swm^37Dh-1 is a non-suppressor of visible phenotype of Scer\GAL4^vg.PM, ct^RNAi.cGa.UAS

(Casso et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

swm^37Dh-1/swm[+] is an enhancer of wing phenotype of hh^Mrt

(Casso et al., 2008)

Suppressor of

Statement

Reference

swm^37Dh-1/swm[+] is a suppressor of wing vein phenotype of Scer\GAL4^ptc-559.1, smo^RNAi.UAS.WIZ

(Casso et al., 2008)

Scer\GAL4^C-765/swm^37Dh-1 is a suppressor | partially of wing phenotype of Scer\GAL4^C-765, smo^{5A.UAS.Tag:FLAG}

(Casso et al., 2008)

swm^37Dh-1 is a suppressor of eye phenotype of rux¹

(Casso et al., 2008)

NOT Suppressor of

Statement

Reference

swm^37Dh-1 is a non-suppressor of wing margin phenotype of Scer\GAL4^vg.PM, ct^RNAi.cGa.UAS

(Casso et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The rux¹ rough eye phenotype is partially suppressed by swm^37Dh-1.

The severity of the anterior wing outgrowths phenotype seen in hh^Mrt/+ flies is enhanced by swm^37Dh-1/+.

swm^37Dh-1/swm^F15 progeny of swm^F15 female germline clones are larval lethal.

(Casso et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

swm^F11

(Casso et al., 2008)

swm^F4

(Casso et al., 2008)

swm^F15

(Casso et al., 2008)

swm^F14

(Casso et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3445

swm^37Dh-1 rdo¹ hook¹ pr¹/CyO

Kyoto

107043

swm^37Dh-1 rdo¹ hook¹ pr¹/CyO

Notes on Origin

Discoverer

Wright.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

l(2)37Dh¹

(Gay and Contamine, 1993)

l(2)E1

(Wright et al., 1976)

swm^37Dh-1

(Ribot et al., 2022, Kahsai and Cook, 2018, Casso et al., 2008)

swm^DH1

(Casso et al., 2008)

swm^Dh-1

(Casso et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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