Polytene chromosomes normal (Ashburner).
Carries a frameshift mutation in which two nucleotides have been removed, resulting in a new translational frame and a premature stop codon after the addition of 15 new amino acids.
A 2 bp deletion at amino acid position 215 which results in a frame shift and a translational stop 14 amino acids downstream, leading to a truncated protein containing only the first DM14 domain.
Clones double mutant for l(2)gd11 and ft8 or ftG show extensive overgrowth. Wing discs bend at the hinge region and show many extra folds that probably result from excess proliferation. Discs are initially smaller than wild type or either single mutant but eventually outgrow them. Leg discs are greatly overgrown, approximating the size of a wild type wing disc, and show no sign of duplications, except for the first leg disc. Haltere disc is also overgrown with an occasional duplication of the capitellum pouch. The eye-antennal disc is massively overgrown and becomes the largest disc, with duplications and triplications of the antenna knob and the retinal field. Genital discs duplicate and show many extra folds. Double mutants do not survive to pharate adults. Clones double mutant for l(2)gd11 and ft8 produce very few bristles. The cuticle of clones produced in the head or notum is usually twisted or rough. Clones induced in the wings interfere with wing vein formation. Internal vesicles form but do not form bristles. Double mutant clones are larger than for either single mutant. Wing discs from l(2)gd11, ds38k double mutants are large and have variable morphology, often with a series of frill-like folds on the edges of the discs. Leg discs are larger and thicker than for ds38k alone. The haltere disc duplicates, triplicates or quadruplicates. The eye antenna disc shows a pair of knob-like structures in the anterior of the antenna field that probably represent presumptive antennae. Animals usually die in the larval or early pupal stage, and never reach the pharate adult stage. Clones double mutant for ds38k and ds38k form protrusions due to abnormal morphogenesis that might result from an excess of cells. Wing discs from l(2)gd11, cg1 double mutants show a variety of extra folds and extensive overgrowth. The second and third leg, haltere, female genital and eye-antenna discs all show duplication of various structures. These animals fail to form pharate adults and die as larvae or pupae. dppd5 suppresses the duplicative ability of second leg discs in ft8, l(2)gd11/l(2)gd11 mutants. Imaginal discs from ds38k l(2)gd11/l(2)gd11 larvae resemble those of ft8 l(2)gd11/l(2)gd11 rather than l(2)gd11/l(2)gd11 in that wing, haltere, second and third leg discs are duplicated.
Pharate adult wings of l(2)gd11 vg1 double mutants are partially restored compared to the single homozygotes. Clones in a vg1 homozygous background are recognisable by growths protuding from the wing blade, thus partially restoring the wing pattern by extensions of the wing blade areas (three-fold increase in wing blade area) and a span of clonal tissue in both dorsal and ventral wing surfaces.