Stop codon at amino acid position 72 resulting in a predicted protein that terminates immediately after the amino-terminal "Delta" domain of the protein.
Stop codon at amino acid 72.
Nucleotide substitution: ?651?.
Encodes a truncated protein lacking the DNA binding and dimerization domain and the amino-terminal phosphorylation sites.
Amino acid replacement: K71term.
JraIA109 does not protect Df(1)su(s)R194/+ clones in the eye; Df(1)su(s)R194/+ ; JraIA109 clones are not recovered in the adult eye in animals with mosaic eyes containing two genotypes of cells with respect to RpL36; cells which are Df(1)su(s)R194/+ and cells in which the haplo-insufficiency of Df(1)su(s)R194/+ for RpL36 has been rescued by RpL36+t4 (in a wild-type background the Df(1)su(s)R194/+ clones are eliminated by cell competition and are not seen in the adult eye in these animals). Also, the proportion of Df(1)su(s)R194/+ cells in the larval eye disc is not increased by the presence of JraIA109.
JraIA109/+ ; mbf12 double mutant adults treated with hydrogen peroxide at the onset of metamorphosis often have cuticle defects, which manifest as a depressed patch of naked cuticle at the dorsal midline.