Allele Dmel\her^mat-1

General Information
Symbol	Dmel\her^mat-1	Species	D. melanogaster
Name		FlyBase ID	FBal0009283
Feature type	allele	Associated gene	Dmel\her

Allele class	hypomorphic allele - genetic evidence
Mutagen	spontaneous
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Pultz et al., 1994)
Mutagen	spontaneous (Li and Baker, 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by aberration	In(2L)her^mat-1 (Li and Baker, 1998)
Cytology	Polytene chromosomes normal. (Pultz et al., 1994)
Phenotypic Data
Phenotypic Class
	female semi-sterile (Li and Baker, 1998) lethal \| embryonic stage \| maternal effect (ten Bosch et al., 2006) lethal \| embryonic stage \| maternal effect (with her¹) (ten Bosch et al., 2006) lethal \| female \| maternal effect \| heat sensitive (Pultz et al., 1994) lethal \| maternal effect \| heat sensitive (Pultz et al., 1994) lethal \| recessive \| heat sensitive (Pultz et al., 1994) male fertile (Li and Baker, 1998) sex-determination defective \| recessive \| heat sensitive (Pultz et al., 1994)
Phenotype Manifest In
	female terminalia \| maternal effect (Pultz et al., 1994) male terminalia \| maternal effect (Pultz et al., 1994) sex comb \| maternal effect (Pultz et al., 1994)
Detailed Description
	Statement Reference Homozygous her^mat-1 and heterozygous her^mat-1/her¹ exhibit maternal-effect embryonic lethality, which both sexes affected equally. (ten Bosch et al., 2006) Daughters of her¹/her^mat-1 mothers are severely affected by the presence of a sisA point mutation and Sxl^f9, viability can be restored by the presence of Sxl^M1. The presence of Sxl^fLS does not affect the daughters. (Pultz and Baker, 1995) Homozygous females are transformed to intersexes under restrictive and semi-restrictive temperatures (29^oC and 25^oC). Mutant males show a weak transformation to intersexuality in the sixth sternite has bristles. Surviving daughters of homozygotes and transheterozygotes raised at semi-restrictive temperatures show a high frequency of morphological defects not seen in sons. Maternal effect female lethality is enhanced by Sxl^f1. Severely restrictive conditions (29^oC for more than 2 days) reveals maternal sex-nonspecific lethality for all heteroallelic combinations except her³/her²: embryos show defect in gastrulation and differentiation of the cuticles. (Pultz et al., 1994) Homozygous females produce 1 daughter to 5.5 sons. Abnormal sex ratio caused by inviability of females. l(2)mat does not seem to be allelic to da, which has a similar effect. RK3.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	her^mat-1 is rescued by her^hs.PL (Li and Baker, 1998)
Comments	Heat induced expression of her^hs.PL rescues female semi-sterility. (Li and Baker, 1998)
Stocks ( 2 )
Bloomington	331 her^mat-1/SM5
Kyoto	105855 her^mat-1/SM5
Notes on Origin
Discoverer	Redfield, Feb. 1923.

Comments
	Severely defective in maternal her functions but wild type in zygotic her functions. (Pultz and Baker, 1995) Relative severity of the effects on female and male sexual differentiation is her³ > her¹ > her² > her^mat-1. Relative severity of the effects on viability is her³ > her¹ = her² > her^mat-1. (Pultz et al., 1994)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	her^l(2)mat (ten Bosch et al., 2006) her^mat1 her^mat-1 l(2)mat¹
Name Synonym
Secondary FlyBase IDs
	FBal0086543
References ( 4 )
Research paper	ten Bosch et al., 2006, Development 133(10): 1967--1977 The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcription. [FBrf0190276] Li and Baker, 1998, Development 125(2): 225--235 Her, a gene required for sexual differentiation in Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy. [FBrf0100594] Pultz and Baker, 1995, Development 121(1): 99--111 The dual role of hermaphrodite in the Drosophila sex determination regulatory hierarchy. [FBrf0076149] Pultz et al., 1994, Genetics 136(1): 195--207 A genetic analysis of hermaphrodite, a pleiotropic sex determination gene in Drosophila melanogaster. [FBrf0068639]

Allele Dmel\hermat-1

Allele Dmel\her^mat-1