Allele Dmel\dac^P

General Information
Symbol	Dmel\dac^P	Species	D. melanogaster
Name		FlyBase ID	FBal0009297
Feature type	allele	Associated gene	Dmel\dac

Map ( GBrowse )	Untitled Document
Allele class	hypomorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Mardon et al., 1994)
Mutagen	P-element activity (Mardon et al., 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2L:16,485,982..16,485,982 (Mardon et al., 1994, BDGP Project Members, 1994-1999, Chu et al., 2002, Martini et al., 2000, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Spradling et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{PZ} insertion 11bp downstream of the putative dac transcription start site. (Martini et al., 2000) P element inserted 11bp after the start of transcription. (Mardon et al., 1994)
Caused by insertion	P{PZ}dac^P (Mardon et al., 1994, BDGP Project Members, 1994-1999, Chu et al., 2002, Martini et al., 2000, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Spradling et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Ashburner et al., 1999, Spradling et al., 1999) visible \| recessive (Mardon et al., 1994, Martini et al., 2000)
Phenotype Manifest In
	eye (Mardon et al., 1994, Martini et al., 2000) eye-antennal disc (Mardon et al., 1994) leg (Mardon et al., 1994) morphogenetic furrow (Mardon et al., 1994) mushroom body (Martini et al., 2000) mushroom body gamma-lobe (Martini et al., 2000) ommatidium (Mardon et al., 1994) photoreceptor cell R1 (Mardon et al., 1994) photoreceptor cell R2 (Mardon et al., 1994) photoreceptor cell R3 (Mardon et al., 1994) photoreceptor cell R4 (Mardon et al., 1994) photoreceptor cell R5 (Mardon et al., 1994) photoreceptor cell R6 (Mardon et al., 1994) photoreceptor cell R7 (Mardon et al., 1994) photoreceptor cell R8 (Mardon et al., 1994)
Detailed Description
	Statement Reference Homozygous adults have a mild mushroom body phenotype. The eyes are consistently (but less severely than ey²) reduced in size. (Martini et al., 2000) Eyes of homozygotes are reduced and roughened. 50% of ommatidia have either too many or too few photoreceptors, and the ommatidial array is disrupted. Morphogenetic furrow movement is uneven, resulting in a curved furrow that has advanced further at midline than at the periphery of the disc. While legs have normal proximal and distal morphology, femur, tibia and proximal three tarsi are fused and condensed. (Mardon et al., 1994)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference dac^P has visible \| recessive phenotype, enhanceable by hh[+]/hh^rJ413 (Mardon et al., 1994) dac^P has visible phenotype, enhanceable by ey²/ey² (Martini et al., 2000)
Enhancer of
Statement Reference dac^P/dac^P is an enhancer of visible phenotype of ey² (Martini et al., 2000, Martini et al., 2000)
Suppressor of
Statement Reference dac^P/dac[+] is a suppressor of visible \| heat sensitive phenotype of peb¹ (Wilk et al., 2004)
Other
Statement Reference Egfr^t1, dac^P has visible phenotype (Mardon et al., 1994, Mardon et al., 1994)
Phenotype Manifest In
Enhanced by
Statement Reference dac^P has eye phenotype, enhanceable by ey²/ey² (Martini et al., 2000) dac^P has eye phenotype, enhanceable by hh[+]/hh^rJ413 (Mardon et al., 1994)
NOT Enhanced by
Statement Reference dac^P has mushroom body gamma-lobe phenotype, non-enhanceable by ey²/ey² (Martini et al., 2000) dac^P has mushroom body phenotype, non-enhanceable by ey[+]/ey^D1Da (Martini et al., 2000) dac^P has mushroom body phenotype, non-enhanceable by ey[+]/ey^JD (Martini et al., 2000) dac^P has mushroom body phenotype, non-enhanceable by ey²/ey² (Martini et al., 2000) dac^P has phenotype, non-enhanceable by ey[+]/ey^D1Da (Martini et al., 2000) dac^P has phenotype, non-enhanceable by ey[+]/ey^JD (Martini et al., 2000) dac^P has phenotype, non-enhanceable by ey²/ey² (Martini et al., 2000)
Enhancer of
Statement Reference dac^P/dac^P is an enhancer of eye phenotype of ey² (Martini et al., 2000, Martini et al., 2000)
Suppressor of
Statement Reference dac^P/dac[+] is a suppressor of eye \| heat sensitive phenotype of peb¹ (Wilk et al., 2004) dac^P is a suppressor of phenotype of Egfr^E3 (Mardon et al., 1994)
Other
Statement Reference Egfr^t1, dac^P has eye phenotype (Mardon et al., 1994, Mardon et al., 1994)
Additional Comments
Genetic Interactions
Statement Reference The eyes of dac^P; ey² double homozygotes are consistently very small or absent. (Martini et al., 2000) Suppresses the rough eye phenotype of Egfr^E3. dac^P, Egfr^t1 double homozygotes have a reduced, rough eye phenotype that exceeds that of either mutant alone or the expected additive effects of the two mutants. hh^rJ413 dominantly enhances the recessive eye phenotype of dac^P. (Mardon et al., 1994)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	12047 P{PZ}dac^P/CyO; ry⁵⁰⁶
Notes on Origin
Discoverer	G. Rubin.

Comments
	Complements: heix^k11403. Complements: Cyt-c-d^bln1. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	dac^P1 (Akimoto et al., 2005) dac^P dac^rK364 (Ashburner et al., 1999.10.12, ) l(2)rK364 (Spradling et al., 1999) l(2)rK364^rK364
Name Synonym
Secondary FlyBase IDs

References ( 12 )
Research paper	Akimoto et al., 2005, Dev. Dyn. 233(3): 993--997 Enhancer trapping with a red fluorescent protein reporter in Drosophila. [FBrf0187417] Miguel-Aliaga et al., 2004, Development 131(23): 5837--5848 Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification. [FBrf0180178] Tavsanli et al., 2004, Dev. Biol. 272(1): 231--247 Structure-function analysis of the Drosophila retinal determination protein Dachshund. [FBrf0179474] Wilk et al., 2004, Genetics 168(1): 281--300 Dose-sensitive autosomal modifiers identify candidate genes for tissue autonomous and tissue nonautonomous regulation by the Drosophila nuclear zinc-finger protein, hindsight. [FBrf0180294] Chu et al., 2002, Development 129(3): 695--704 Limb type-specific regulation of bric a brac contributes to morphological diversity. [FBrf0144840] Martini et al., 2000, Development 127(12): 2663--2672 The retinal determination gene, dachshund, is required for mushroom body cell differentiation. [FBrf0128567] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Mardon et al., 1994, Development 120(12): 3473--3486 dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. [FBrf0075101]
Supplementary material	Ashburner et al., 1999, Genetics 153(1): Table S1. P-element insertions in the Adh region. [FBrf0112150]
Personal communication to FlyBase	Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\dacP

Allele Dmel\dac^P