FlyBase Allele Report: Dmel\Cka[s1883]

General Information

Symbol

Dmel\Cka^s1883

Species

D. melanogaster

Name

FlyBase ID

FBal0009303

Feature type

allele

Associated gene

Dmel\Cka

Associated Insertion(s)

P{lacW}Cka^s1883

Carried in Construct

Also Known As

l(2)s1883

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{lacW}Cka^s1883

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die before end of pupal stage (with Cka⁰⁵⁸³⁶)

(Weng and Du, 2002)

lethal - all die before end of pupal stage | recessive

(Weng and Du, 2002)

some die during pupal stage (with Cka⁰⁵⁸³⁶)

(Weng and Du, 2002)

some die during pupal stage | recessive

(Weng and Du, 2002)

Phenotype Manifest In

imaginal disc (with Cka⁰⁵⁸³⁶)

(Weng and Du, 2002)

Detailed Description

Statement

Reference

Cka⁰⁵⁸³⁶/Cka^s1883 mutant eye discs display a variable reduction in disc size. In some discs overall morphology appears normal. Malformed and misfolded discs are also observed, with a higher frequency in smaller discs.

(Weng and Du, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Cka[+]/Cka^s1883 is a non-enhancer of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Suppressor of

Statement

Reference

Cka[+]/Cka^s1883 is a suppressor | partially of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

NOT Suppressor of

Statement

Reference

Cka[+]/Cka^s1883 is a non-suppressor of abnormal neuroanatomy | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Cka[+]/Cka^s1883 is a non-enhancer of developing neuron | larval stage | ectopic | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Cka[+]/Cka^s1883 is a non-enhancer of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Cka[+]/Cka^s1883 is a non-enhancer of peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Suppressor of

Statement

Reference

Cka[+]/Cka^s1883 is a suppressor | partially of developing neuron | larval stage | decreased number | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Cka[+]/Cka^s1883 is a suppressor | partially of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^UAS.Tag:MYC, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

NOT Suppressor of

Statement

Reference

Cka[+]/Cka^s1883 is a non-suppressor of developing neuron | ectopic | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Cka[+]/Cka^s1883 is a non-suppressor of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Cka[+]/Cka^s1883 is a non-suppressor of peripodial epithelium of eye disc | larval stage | somatic clone - tissue specific phenotype of Mitf^KK113614, Scer\GAL4^Act5C.PI

(Zhang et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Cka⁰⁵⁸³⁶

(BDGP Project Members, 1994-1999)

Cka^k12603

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12039

w¹¹¹⁸; P{lacW}Cka^s1883/CyO

Notes on Origin

Discoverer

M. Scott.

Comments

Complements: mts⁰²⁴⁹⁶. Complements: l(2)37Ad^02660b. Complements: Bsg⁰⁶²⁴³. Complements: l(2)k10210^k10210. Complements: mts^s5286.

(BDGP Project Members, 1994-1999)

Complements: baf¹.

(Furukawa et al., 2003)

Complements: Df(2L)baf².

(Furukawa et al., 2003)

Complements: l(2)k10210^k10210.

(Furukawa et al., 2003)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Cka¹⁴⁵¹

(Weng and Du, 2002)

Cka^s1883

(Zhang et al., 2024, Neal et al., 2022, Liu et al., 2016)

WD-40-family-member^s1883

l(2)05836^s1883

(BDGP Project Members, 1994-1999)

l(2)s1883

(Furukawa et al., 2003, Spradling et al., 1999)

l(2)s1883^s1883

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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