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General Information
Symbol
Dmel\Uba1s3484
Species
D. melanogaster
Name
FlyBase ID
FBal0009310
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
The P{lacW} insertion is at 436bp after the start of the open reading frame, within intron 1.
Insertion components
P{lacW}Uba1s3484
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Uba1 mutant clones in sensory neurons in adult wing do not display any defects in injury-induced axon degeneration (following an axotomy, the severed axons are cleared away normally).
Uba1s3484/Uba1s3484 flies exhibit complete lethality. Uba1UY3010/Uba1s3484 flies are viable in combination with Scer\GAL4da.G32, but exhibit total lethality in the absence of a GAL4 driver.
Third larval instar discs are overgrown in mosaic animals. Adults containing homozygous clones have overgrown eyes.
Uba1s3484 mutants fail to efficiently sever their larval dendrites during metamorphosis, with the retention of approximately 45% of large dendritic branches at 20 hours after pupal formation.
Mutant neuroblast clones show grossly normal axonal projections to both the dorsal and medial lobes. However there are fewer cells in mutant clones as compared to wild-type. Pruning defects are evident at 18h after puparium formation (APF) indicated by the persistence of continuous larval branches. Dendrite pruning is also inhibited in clones. Although mutant mushroom body neurons survive into adulthood more than 10 days after clone induction, abnormal morphology of axons is clearly visible.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Suppressor of
Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
The axon degeneration in sensory neurons clones in the adult wing expressing Ect4ΔARM.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4VGlut-OK371 can be suppressed by combination with Uba1.
Xenogenetic Interactions
Statement
Reference
Uba1s3484/+ fails to suppress the notched wing phenotype and lethality observed in flies expressing Mmus\BaxScer\UAS.cGa under the control of Scer\GAL4vg.PM.
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
M. Scott.
Comments
Comments
Precise excision of the insertion reverts the lethal and overgrowth phenotypes.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)