Alg3tid1/Alg3tid2 transheterozygotes develop into giant larvae that bear imaginal disc tumors and show delayed puparium formation, as compared to controls. Imaginal disc proliferation rate in Alg3tid1/Alg3tid2 transheterozygotes is slow, such that discs are initially smaller than controls; eventually, eye and wing discs show disorganized tissue architecture (abnormal tissue thickness and tissue folding, cells with altered shape but apparently normal cell polarity) and moderate overgrowth associated with a significant increase in cell number, as compared to controls; xenografts into the abdomen of control hosts continue proliferating and overgrow dramatically, with more severe architectural defects, as compared to controls.
The generation of fully homozygous Alg3tid1 eye discs in an otherwise heterozygous larva leads to disorganized eye discs (milder defects than those in Alg3tid1/Alg3tid2 transheterozygotes) and induces pupal lethality.
Mutants have tumorous wing discs.
Shows autonomously growing imaginal disc tumors and lethality during the larval to pupal transition.
Mutant imaginal discs implanted into wild-type flies proliferate as non-invasive tumours that kill the host in 10 to 14 days. Pieces of mutant imaginal disc implanted into larvae give rise to chitinous structures containing some hairs but no bristles in the adult fly.