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General Information
Symbol
Dmel\Alg3tid1
Species
D. melanogaster
Name
FlyBase ID
FBal0009359
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
C23705941T
Amino acid change:
Q375term | Alg3-PA
Reported amino acid change:
Q375term
Comment:
Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: Q375term.
A nonsense mutation at glutamine 375, resulting in a truncation of the remaining 135 amino acids of the predicted Alg3 protein.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Alg3tid1/Alg3tid2 transheterozygotes develop into giant larvae that bear imaginal disc tumors and show delayed puparium formation, as compared to controls. Imaginal disc proliferation rate in Alg3tid1/Alg3tid2 transheterozygotes is slow, such that discs are initially smaller than controls; eventually, eye and wing discs show disorganized tissue architecture (abnormal tissue thickness and tissue folding, cells with altered shape but apparently normal cell polarity) and moderate overgrowth associated with a significant increase in cell number, as compared to controls; xenografts into the abdomen of control hosts continue proliferating and overgrow dramatically, with more severe architectural defects, as compared to controls. The generation of fully homozygous Alg3tid1 eye discs in an otherwise heterozygous larva leads to disorganized eye discs (milder defects than those in Alg3tid1/Alg3tid2 transheterozygotes) and induces pupal lethality.
Mutants have tumorous wing discs.
Shows autonomously growing imaginal disc tumors and lethality during the larval to pupal transition.
Mutant imaginal discs implanted into wild-type flies proliferate as non-invasive tumours that kill the host in 10 to 14 days. Pieces of mutant imaginal disc implanted into larvae give rise to chitinous structures containing some hairs but no bristles in the adult fly.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
NOT suppressed by
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
NOT suppressed by
Other
Additional Comments
Genetic Interactions
Statement
Reference
The expression of egrUAS.Venus under the control of Scer\GAL4r4 in a Alg3tid1/Alg3tid2 transheterozygous background leads to an increase in cell death (DCP-1-positive cells) in the wing disc, as compared to controls.
Alg3tid1 ptctuf-1 double homozygous larvae develop tumourous imaginal discs and die at the larval/pupal transition, just as Alg3tid1 homozygotes do. The phenotype of Alg3tid1 ptc9 double mutant embryos resembles that of ptc9 single mutants.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Induced in: the "a px o" strain, which contains two copies of Alg3 as this strain carries a duplication of genomic sequences (Dp(2;2)KD).
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)