C23705941T
Q375term | Alg3-PA
Q375term
Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.
Amino acid replacement: Q375term.
A nonsense mutation at glutamine 375, resulting in a truncation of the remaining 135 amino acids of the predicted Alg3 protein.
large body | larval stage (with Alg3tid2)
visible | larval stage (with Alg3tid2)
Alg3tid1/Alg3tid2 transheterozygotes develop into giant larvae that bear imaginal disc tumors and show delayed puparium formation, as compared to controls. Imaginal disc proliferation rate in Alg3tid1/Alg3tid2 transheterozygotes is slow, such that discs are initially smaller than controls; eventually, eye and wing discs show disorganized tissue architecture (abnormal tissue thickness and tissue folding, cells with altered shape but apparently normal cell polarity) and moderate overgrowth associated with a significant increase in cell number, as compared to controls; xenografts into the abdomen of control hosts continue proliferating and overgrow dramatically, with more severe architectural defects, as compared to controls.
The generation of fully homozygous Alg3tid1 eye discs in an otherwise heterozygous larva leads to disorganized eye discs (milder defects than those in Alg3tid1/Alg3tid2 transheterozygotes) and induces pupal lethality.
Mutants have tumorous wing discs.
Shows autonomously growing imaginal disc tumors and lethality during the larval to pupal transition.
Mutant imaginal discs implanted into wild-type flies proliferate as non-invasive tumours that kill the host in 10 to 14 days. Pieces of mutant imaginal disc implanted into larvae give rise to chitinous structures containing some hairs but no bristles in the adult fly.
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, enhanceable by egrUAS.cIa/Scer\GAL4r4
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-enhanceable by Xbp1GD4745/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-enhanceable by crbHMS02036/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-enhanceable by aPKCGL00007/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-enhanceable by Scer\GAL4hh-Gal4/Xbp1HMS03015
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-enhanceable by Scer\GAL4hh-Gal4/sip3EY11980
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-enhanceable by sip3EY11980/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, suppressible by hpoUAS.cPa/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, suppressible | partially by Scer\GAL4hh-Gal4/bskK53R.UAS
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, suppressible | partially by Scer\GAL4hh-Gal4/grndKK109939
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, suppressible | partially by grndextra.UAS/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, suppressible by egrGD12658/Scer\GAL4αTub84B.PL
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, suppressible by egrGD12658/Scer\GAL4r4
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, suppressible by wtsUAS.Tag:MYC/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by Xbp1GD4745/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by Scer\GAL4hh-Gal4/wgndsRNA.UAS
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by Scer\GAL4hh-Gal4/egrGD12658
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by Scer\GAL4Hml.Δ/egrGD12658
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by crbHMS02036/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by Scer\GAL4hh-Gal4/Xbp1HMS03015
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by aPKCGL00007/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by Scer\GAL4hh-Gal4/sip3EY11980
Alg3tid2/Alg3tid1 has tumorigenic | larval stage phenotype, non-suppressible by sip3EY11980/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1, Scer\GAL4r4, egrUAS.Venus has increased cell death phenotype
Alg3tid2/Alg3tid1 has wing disc phenotype, enhanceable by egrUAS.cIa/Scer\GAL4r4
Alg3tid2/Alg3tid1 has wing disc phenotype, non-enhanceable by Xbp1GD4745/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has wing disc phenotype, non-enhanceable by crbHMS02036/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has wing disc phenotype, non-enhanceable by aPKCGL00007/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has wing disc phenotype, non-enhanceable by Scer\GAL4hh-Gal4/Xbp1HMS03015
Alg3tid2/Alg3tid1 has wing disc phenotype, non-enhanceable by Scer\GAL4hh-Gal4/sip3EY11980
Alg3tid2/Alg3tid1 has wing disc phenotype, non-enhanceable by sip3EY11980/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has wing disc phenotype, suppressible | partially by hpoUAS.cPa/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has wing disc phenotype, suppressible | partially by Scer\GAL4hh-Gal4/bskK53R.UAS
Alg3tid2/Alg3tid1 has wing disc phenotype, suppressible | partially by Scer\GAL4hh-Gal4/grndKK109939
Alg3tid2/Alg3tid1 has wing disc phenotype, suppressible | partially by grndextra.UAS/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has wing disc phenotype, suppressible by egrGD12658/Scer\GAL4αTub84B.PL
Alg3tid2/Alg3tid1 has wing disc phenotype, suppressible by egrGD12658/Scer\GAL4r4
Alg3tid2/Alg3tid1 has wing disc phenotype, suppressible | partially by wtsUAS.Tag:MYC/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by Xbp1GD4745/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by Scer\GAL4hh-Gal4/wgndsRNA.UAS
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by Scer\GAL4hh-Gal4/Xbp1HMS03015
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by Scer\GAL4hh-Gal4/egrGD12658
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by Scer\GAL4Hml.Δ/egrGD12658
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by crbHMS02036/Scer\GAL4hh-Gal4
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by aPKCGL00007/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by Scer\GAL4hh-Gal4/sip3EY11980
Alg3tid2/Alg3tid1 has wing disc phenotype, non-suppressible by sip3EY11980/Scer\GAL4Bx-MS1096
Alg3tid2/Alg3tid1, Scer\GAL4r4, egrUAS.Venus has wing disc phenotype
The expression of egrUAS.Venus under the control of Scer\GAL4r4 in a Alg3tid1/Alg3tid2 transheterozygous background leads to an increase in cell death (DCP-1-positive cells) in the wing disc, as compared to controls.
Alg3tid2/Alg3tid1 is rescued by Alg3UAS.cVa/Scer\GAL4αTub84B.PL
Alg3tid1 is rescued by Alg3UAS.cVa/Scer\GAL4αTub84B.PL
Alg3tid2/Alg3tid1 is rescued by Alg3Tub.cVa
Alg3tid1 is rescued by Alg3Tub.cVa
Alg3tid2/Alg3tid1 is partially rescued by Scer\GAL4hh-Gal4/Alg3UAS.cVa
Alg3tid2/Alg3tid1 is not rescued by Alg3UAS.cVa/Scer\GAL4r4