Allele Dmel\l(2)tid²

General Information
Symbol	Dmel\l(2)tid²	Species	D. melanogaster
Name		FlyBase ID	FBal0009360
Feature type	allele	Associated gene	Dmel\l(2)tid

Allele class
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	X ray
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name X95249 CAA64538

UniProtKB/Swiss-Prot	Q27237
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference A deletion of 24bp downstream of the 3' untranslated region (nucleotides 5047-5070 of the 7047bp HindIII genomic fragment shown in Figure 1. of FBrf0102353) and a duplication of the nucleotide at position 5044 of the same HindIII genomic fragment. (Kurzik-Dumke et al., 1998)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Kurzik-Dumke et al., 1995) tumorigenic (Kurzik-Dumke et al., 1995)
Phenotype Manifest In
	imaginal disc (Kurzik-Dumke et al., 1995)
Detailed Description
	Statement Reference Shows autonomously growing imaginal disc tumors and lethality during the larval to pupal transition. (Kurzik-Dumke et al., 1995)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	l(2)tid² is rescued by l(2)tid^+t7.0 (Kurzik-Dumke et al., 1995)
Not rescued by	l(2)tid² is not rescued by l(2)tid^tKa (Kurzik-Dumke et al., 1995) l(2)tid² is not rescued by l(2)tid^tKb (Kurzik-Dumke et al., 1995)
Comments	Tumorous phenotype can be rescued by l(2)tid^+t7.0. (Kurzik-Dumke et al., 1995)
Stocks ( 0 )

Notes on Origin
Discoverer
	Induced in: the "b If" strain. (Kurzik-Dumke et al., 1998)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	l(2)tid²
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Kurzik-Dumke et al., 1998, Cell Stress Chaperones 3(1): 12--27 Mitochondrial localization and temporal expression of the Drosophila melanogaster DnaJ homologous tumor suppressor Tid50. [FBrf0102353] Kurzik-Dumke et al., 1995, Dev. Genet. 16(1): 64--76 Tumor suppression in Drosophila is causally related to the function of the lethal(2)tumorous imaginal discs gene, a dnaJ homolog. [FBrf0080183]
Review	Gateff and Mechler, 1989, Crit. Rev. Oncogen. 1: 221--245 Tumor-suppressor genes of Drosophila melanogaster. [FBrf0049455]
Abstract	Kurzik-Dumke et al., 1995, Europ. Dros. Res. Conf. 14: 334 The Drosophila nested genes lethal(2)tumorous imaginal discs (l(2)tid), lethal(2)neighbour of tid (l(2)not) and lethal(2)relative of tid (l(2)rot) represent in genetic terms one complementation group. [FBrf0083244]

Allele Dmel\l(2)tid2

Allele Dmel\l(2)tid²