FlyBase Allele Report: Dmel\frc[00073]

General Information

Symbol

Dmel\frc⁰⁰⁰⁷³

Species

D. melanogaster

Name

FlyBase ID

FBal0009365

Feature type

allele

Associated gene

Dmel\frc

Associated Insertion(s)

P{PZ}frc⁰⁰⁰⁷³

Carried in Construct

Also Known As

l(3)00073

Genomic Maps

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Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Selva et al., 2001)

Mutagen

P-element activity

(Luders et al., 2003, Goto et al., 2001, Selva et al., 2001, Spradling et al., 1999, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

transposable element insertion site

3L:17,433,113..17,433,113 [+]

(Negreiros et al., 2018, Luders et al., 2003, Goto et al., 2001, Selva et al., 2001, Spradling et al., 1999, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

P{PZ} insertion at nucleotide position 63 of the CG3874 gene prediction (which corresponds to frc), in the 5' untranslated region.

(Selva et al., 2001)

The P{PZ}frc⁰⁰⁰⁷³ insertion maps within both frc and CG32174 (nested genes).

(FlyBase, 1996-)

Insertion components

P{PZ}frc⁰⁰⁰⁷³

Product class / Tool use(s)

Encoded product / tool

Tagged with

nuclear protein localization tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/first instar larval cuticle

(Zhu et al., 2005)

embryonic segment

(Zhu et al., 2005)

mesoderm | germline clone

(Selva et al., 2001)

Detailed Description

Statement

Reference

frc⁰⁰⁰⁷³ embryos that lack both maternal and zygotic sfl exhibit a segment polarity phenotype. Salivary glands are present in these mutants. Females carrying frc⁰⁰⁰⁷³ ventral follicle cell clones do not produce dorsalized embryos.

(Zhu et al., 2005)

When homozygous clones are made in the follicle cells, no dorsalisation phenotypes are seen in the resulting embryos.

(Luders et al., 2003)

Homozygotes die at the late pupal stage. Embryos derived from homozygous germline clones die during embryogenesis with strong segment polarity and mesodermal patterning defects that can be paternally rescued to viability.

(Selva et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

frc[+]/frc⁰⁰⁰⁷³ is an enhancer of visible | dominant phenotype of N^Ax-E2

(Selva et al., 2001)

Suppressor of

Statement

Reference

frc[+]/frc⁰⁰⁰⁷³ is a suppressor of visible phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Enhancer of

Statement

Reference

frc[+]/frc⁰⁰⁰⁷³ is an enhancer of wing vein phenotype of N^Ax-E2

(Selva et al., 2001)

Suppressor of

Statement

Reference

frc[+]/frc⁰⁰⁰⁷³ is a suppressor of eye phenotype of Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Additional Comments

Genetic Interactions

Statement

Reference

When wg^Scer\UAS.cKa is expressed under the control of Scer\GAL4^prd.RG1 in a an embryo that is zygotically and maternally mutant for frc⁰⁰⁰⁷³, naked cuticle is restored in a typical pair-rule pattern. When hh^Scer\UAS.cIa is expressed under the control of Scer\GAL4^prd.RG1 in a an embryo that is zygotically and maternally mutant for frc⁰⁰⁰⁷³, naked cuticle is restored in a typical pair-rule pattern. The penetrance of the loss of wing vein phenotype seen in N^Ax-E2/+ flies (8.7%) is enhanced to 30% by one copy of frc⁰⁰⁰⁷³.

(Selva et al., 2001)

Xenogenetic Interactions

Statement

Reference

One copy of frc⁰⁰⁰⁷³ suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

(Ambegaokar and Jackson, 2011)

Complementation and Rescue Data

Fails to complement

frc¹⁰⁰⁹⁸

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11484

P{PZ}frc⁰⁰⁰⁷³ Coq4⁰⁰⁰⁷³ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Excision of the P{PZ} element fully reverses the germ-line clone phenotype.

(Selva et al., 2001)

Complements: frc⁰²⁶¹⁹. Complements: frc^j2E3. Complements: Eip74EF^neo24.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

frc⁰⁰⁰⁷³

(Negreiros et al., 2018)

frc⁰⁰⁷³

(Ambegaokar and Jackson, 2011)

frc^l(3)00073

(Selva et al., 2001)

l(3)00073

(Richardson, 2005.2.11, Brumby et al., 2004, Goto et al., 2001, Spradling et al., 1999)

l(3)00073⁰⁰⁰⁷³

(BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (13)

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