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General Information
Symbol
Dmel\frc00073
Species
D. melanogaster
Name
FlyBase ID
FBal0009365
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)00073
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
P{PZ} insertion at nucleotide position 63 of the CG3874 gene prediction (which corresponds to frc), in the 5' untranslated region.
The P{PZ}frc00073 insertion maps within both frc and CG32174 (nested genes).
Insertion components
P{PZ}frc00073
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
frc00073 embryos that lack both maternal and zygotic sfl exhibit a segment polarity phenotype. Salivary glands are present in these mutants. Females carrying frc00073 ventral follicle cell clones do not produce dorsalized embryos.
When homozygous clones are made in the follicle cells, no dorsalisation phenotypes are seen in the resulting embryos.
Homozygotes die at the late pupal stage. Embryos derived from homozygous germline clones die during embryogenesis with strong segment polarity and mesodermal patterning defects that can be paternally rescued to viability.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
frc[+]/frc00073 is an enhancer of visible | dominant phenotype of NAx-E2
Suppressor of
Statement
Reference
frc[+]/frc00073 is a suppressor of visible phenotype of Hsap\MAPTGMR.Ex.PJ
Phenotype Manifest In
Enhancer of
Statement
Reference
frc[+]/frc00073 is an enhancer of wing vein phenotype of NAx-E2
Suppressor of
Statement
Reference
frc[+]/frc00073 is a suppressor of eye phenotype of Hsap\MAPTGMR.Ex.PJ
Additional Comments
Genetic Interactions
Statement
Reference
When wgScer\UAS.cKa is expressed under the control of Scer\GAL4prd.RG1 in a an embryo that is zygotically and maternally mutant for frc00073, naked cuticle is restored in a typical pair-rule pattern. When hhScer\UAS.cIa is expressed under the control of Scer\GAL4prd.RG1 in a an embryo that is zygotically and maternally mutant for frc00073, naked cuticle is restored in a typical pair-rule pattern. The penetrance of the loss of wing vein phenotype seen in NAx-E2/+ flies (8.7%) is enhanced to 30% by one copy of frc00073.
Xenogenetic Interactions
Statement
Reference
One copy of frc00073 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPTGMR.Ex.PJ.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
A. Spradling.
Comments
Comments
Excision of the P{PZ} element fully reverses the germ-line clone phenotype.
Complements: frc02619. Complements: frcj2E3. Complements: Eip74EFneo24.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (12)