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General Information
Symbol
Dmel\not02069
Species
D. melanogaster
Name
FlyBase ID
FBal0009432
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
not2
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{PZ} insertion in the first exon, 538bp downstream of the start codon.

Insertion components
P{PZ}not02069
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

axon & photoreceptor cell R2

axon & photoreceptor cell R3

axon & photoreceptor cell R4

axon & photoreceptor cell R5

photoreceptor cell R1 & axon

photoreceptor cell R2 & axon

photoreceptor cell R3 & axon

photoreceptor cell R4 & axon

photoreceptor cell R5 & axon

photoreceptor cell R6 & axon

Detailed Description
Statement
Reference

In not02069 larvae, many R2-R5 axons fail to terminate in the lamina and instead project into the medulla.

Heterozygotes enhance the position effect variegation of w seen in the In(1)wm4h chromosome.

In hemizygotes R1-R6 neurons project through the lamina and terminate in the medulla. A few appear to stop in the lamina. In the developing optic ganglia the regions of the outer proliferation centre (OPC) and lamina precursor cells (LPC) are closer together and the shape of the inner proliferation centre (IPC) is oval rather than round.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

not02069/not[+] is a suppressor of visible | heat sensitive phenotype of peb1

Phenotype Manifest In
Suppressor of
Statement
Reference

not02069/not[+] is a suppressor of eye | heat sensitive phenotype of peb1

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Excision of the P{PZ} element can revert the phenotype.

Complements: W05014. Complements: l(3)L3930L3930. Complements: l(3)j13B3j13B3. Complements: l(3)neo261.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (17)