FlyBase Allele Report: Dmel\Hsc70-4[03550]

(Brumby et al., 2002, Doughty, 2000.5.9, Hing et al., 1999, Spradling et al., 1999, Braun et al., 1997, Schmucker et al., 1997, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment 1 | maternal effect

(Perrimon et al., 1996)

abdominal segment 2 | maternal effect

(Perrimon et al., 1996)

abdominal segment 3 | maternal effect

(Perrimon et al., 1996)

abdominal segment 4 | maternal effect

(Perrimon et al., 1996)

abdominal segment 5 | maternal effect

(Perrimon et al., 1996)

abdominal segment 6 | maternal effect

(Perrimon et al., 1996)

abdominal segment 7 | maternal effect

(Perrimon et al., 1996)

abdominal segment 8 | maternal effect

(Perrimon et al., 1996)

abdominal segment 9 | maternal effect

(Perrimon et al., 1996)

abdominal segment 10 | maternal effect

(Perrimon et al., 1996)

abdominal segment 11 | maternal effect

(Perrimon et al., 1996)

axon | larval stage

(Bronk et al., 2001)

Bolwig nerve

(Schmucker et al., 1997)

Bolwig organ

(Schmucker et al., 1997)

embryonic/first instar larval cuticle | maternal effect

(Perrimon et al., 1996)

head | anterior | maternal effect

(Perrimon et al., 1996)

melanotic mass

(Braun et al., 1997)

photoreceptor neuron

(Schmucker et al., 1997)

Detailed Description

Statement

Reference

The nerve-evoked excitatory junctional potential (EJP) amplitudes in mutant larvae are reduced to about half that of controls. EJP amplitudes are not reduced by a fatigue of evoked release, because responses sequentially recorded at 0.2 Hz do not progressively diminish. The quantal content of evoked release in homozygotes is reduced to a third to a half of control.

(Bronk et al., 2001)

Shows no interaction with N pathway mutants.

(Hing et al., 1999)

Third instar larvae contain circulating melanotic capsules, and die as early pupae.

(Braun et al., 1997)

The Bolwig's organs show variable disruption of cell clustering in homozygous embryos. A number of photoreceptors are displaced along the path of the Bolwig's nerve (BN) in some embryos. The BN defasciculates on the surface of the optic lobe anlagen in most embryos. the defasciculated BN usually projects abnormally and forms loop-like structures.

(Schmucker et al., 1997)

Germline clones produce eggs with patterning defects: anterior head defects and variable abdominal segmentation defects. Lethality occurs during the larval and pupal stages.

(Perrimon et al., 1996)

visible rough eyes, bent wings, thin, short bristles

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is an enhancer of visible | dominant | homeotic phenotype of Pc³

(Mollaaghababa et al., 2001)

NOT Enhancer of

Statement

Reference

Hsc70-4⁰³⁵⁵⁰ is a non-enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Mollaaghababa et al., 2001)

NOT Suppressor of

Statement

Reference

Hsc70-4⁰³⁵⁵⁰ is a non-suppressor of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Mollaaghababa et al., 2001)

Other

Statement

Reference

Hsc70-4⁰³⁵⁵⁰, brm^K804R.Tag:HA has viable | male phenotype

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰, ph-p⁴¹⁰ has viable phenotype

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+], ph-p⁴¹⁰ has viable phenotype

(Mollaaghababa et al., 2001)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Hsc70-4⁰³⁵⁵⁰ has axon | larval stage phenotype, non-enhanceable by Csp^U1

(Bronk et al., 2001)

NOT suppressed by

Statement

Reference

Hsc70-4⁰³⁵⁵⁰ has axon | larval stage phenotype, non-suppressible by Csp^U1

(Bronk et al., 2001)

Enhancer of

Statement

Reference

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is an enhancer of sex comb | ectopic phenotype of ph-p⁴¹⁰

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is an enhancer of sex comb | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

NOT Enhancer of

Statement

Reference

Hsc70-4⁰³⁵⁵⁰ is a non-enhancer of axon | larval stage phenotype of Csp^U1

(Bronk et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is a non-enhancer of adult abdominal segment 5 phenotype of trx^B11

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰ is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is a non-enhancer of abdominal tergite 4 | male phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is a non-enhancer of abdominal tergite 6 phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is a non-enhancer of adult abdominal segment 4 phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is a non-enhancer of adult abdominal segment 5 | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is a non-enhancer of adult abdominal segment 6 phenotype of Pc³

(Mollaaghababa et al., 2001)

Hsc70-4⁰³⁵⁵⁰/Hsc70-4[+] is a non-enhancer of adult abdominal segment 7 | ectopic phenotype of Pc³

(Mollaaghababa et al., 2001)

Suppressor of

Statement

Reference

Hsc70-4⁰³⁵⁵⁰ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

NOT Suppressor of

Statement

Reference

Hsc70-4⁰³⁵⁵⁰ is a non-suppressor of axon | larval stage phenotype of Csp^U1

(Bronk et al., 2001)

Hsc70-4⁰³⁵⁵⁰ is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Mollaaghababa et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The CycE^JP rough eye phenotype is weakly suppressed by the addition of Hsc70-4⁰³⁵⁵⁰.

(Brumby et al., 2002)

The EJP amplitudes recorded from Hsc70-4⁰³⁵⁵⁰, Csp^U1 double mutant neuromuscular junctions (NMJs) are reduced to about a third of control amplitudes - about the same as each allele individually. The frequency and amplitude of spontaneously occurring mEJPs in double mutants are not different from controls.

(Bronk et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Hsc70-4^HS1-25

(Chang et al., 2002)

Hsc70-4¹⁵⁴⁵

(Wenniger et al., 1998)

Hsc70-4^L4083b

(BDGP Project Members, 1994-1999)