FlyBase Allele Report: Dmel\ftz-f1[03649]

General Information

Symbol

Dmel\ftz-f1⁰³⁶⁴⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0009477

Feature type

allele

Associated gene

Dmel\ftz-f1

Associated Insertion(s)

P{PZ}ftz-f1⁰³⁶⁴⁹

Carried in Construct

Also Known As

ftz-f1^l(3)03649, l(3)03649

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}ftz-f1⁰³⁶⁴⁹

Cytology

Description

P{PZ} element insertion near the transcription start site.

(Yamada et al., 2000)

P{PZ} is inserted into the ftz-f1 coding region.

(Yu et al., 1997)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult optic lobe | P-stage (with ftz-f1^ex7)

(Yamada et al., 2000)

cuticle | maternal effect

(Perrimon et al., 1996)

embryonic/larval salivary gland (with ftz-f1^ex7)

(Yamada et al., 2000)

larval thoracic neuromere | P-stage (with ftz-f1^ex7)

(Yamada et al., 2000)

leg (with ftz-f1^ex7)

(Yamada et al., 2000)

Malpighian tubule (with ftz-f1^ex7)

(Yamada et al., 2000)

midgut (with ftz-f1^ex7)

(Yamada et al., 2000)

segment | maternal effect

(Perrimon et al., 1996)

wing disc (with ftz-f1^ex7)

(Yamada et al., 2000)

Detailed Description

Statement

Reference

In ftz-f1^ex7/ftz-f1⁰³⁶⁴⁹ mutants, no pupation occurs; when ftz-f1^hs.PM is induced at 8hr APF or later, pupation occurs and is delayed (length of delay depends on the timing of the heat shock).

(Akagi et al., 2016)

Most ftz-f1^ex7/ftz-f1⁰³⁶⁴⁹ transheterozygotes die before reaching the prepupal stage, but 3% do progress to prepupae. The development of this 3% arrests before prepupal stage P4. Larval salivary glands are still present even 24 hours after puparium formation (in contrast to wild type). The optic lobes do not expand as in wild type and the subesophageal neuromeres and thoracic neuromeres do not separate. Arrested development is also manifested as leg elongation, edge constriction of the wing disc and morphological changes in the midgut and Malpighian tubules.

(Yamada et al., 2000)

Demonstrates a ftz-like pair rule phenotype.

(Yu et al., 1997)

Germline clones produce eggs with patterning defects: pair rule segmentation defects.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

ftz-f1⁰³⁶⁴⁹ is a non-enhancer of lethal | embryonic stage | maternal effect phenotype of Gug^unspecified

(Zhang et al., 2002)

Suppressor of

Statement

Reference

ftz-f1[+]/ftz-f1⁰³⁶⁴⁹ is a suppressor | partially of lethal phenotype of ari-1³⁷⁴⁷

(Gradilla et al., 2011)

ftz-f1⁰³⁶⁴⁹ is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

Ras85D^V12.sev, ftz-f1⁰³⁶⁴⁹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Suppressed by

Statement

Reference

ftz-f1⁰³⁶⁴⁹/ftz-f1^ex7 has phenotype, suppressible | partially by br^{BRcore.TNT.Q1.Z1.hs}

(Yamada et al., 2000)

ftz-f1⁰³⁶⁴⁹/ftz-f1^ex7 has embryonic/larval salivary gland phenotype, suppressible by br^{BRcore.TNT.Q1.Z1.hs}

(Yamada et al., 2000)

ftz-f1⁰³⁶⁴⁹/ftz-f1^ex7 has embryonic/larval salivary gland phenotype, suppressible | partially by br^Z2.hs

(Yamada et al., 2000)

NOT suppressed by

Statement

Reference

ftz-f1⁰³⁶⁴⁹/ftz-f1^ex7 has embryonic/larval salivary gland phenotype, non-suppressible by br^{BRcore.NS.Z3.hs}

(Yamada et al., 2000)

ftz-f1⁰³⁶⁴⁹/ftz-f1^ex7 has embryonic/larval salivary gland phenotype, non-suppressible by br^BRcore.Z4.hs

(Yamada et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Salivary gland histolysis is rescued in most ftz-f1^ex7/ftz-f1⁰³⁶⁴⁹ transheterozygotes when br^{BRcore.TNT.Q1.Z1.hs} is expressed using heat shock at 10 hours after puparium formation, although other ftz-f1 mutant phenotypes are not rescued in these animals. Salivary gland histolysis is rescued in about half of ftz-f1^ex7/ftz-f1⁰³⁶⁴⁹ transheterozygotes when br^Z2.hs is expressed using heat shock at 10 hours after puparium formation. Salivary gland histolysis is not rescued in ftz-f1^ex7/ftz-f1⁰³⁶⁴⁹ transheterozygotes when either br^{BRcore.NS.Z3.hs} or br^BRcore.Z4.hs is expressed using heat shock at 10 hours after puparium formation.

(Yamada et al., 2000)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by ftz-f1⁰³⁶⁴⁹.

(Maixner et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ftz-f1⁰³⁶⁴⁹ is rescued by ftz-f1^hs.PY

(Yu et al., 1997)

Partially rescued by

ftz-f1⁰³⁶⁴⁹/ftz-f1^ex7 is partially rescued by ftz-f1^hs.PM

(Akagi et al., 2016)

ftz-f1⁰³⁶⁴⁹/ftz-f1^ex7 is partially rescued by ftz-f1^hs.PM

(Yamada et al., 2000)

Comments

In ftz-f1^ex7/ftz-f1⁰³⁶⁴⁹ mutants, no pupation occurs when ftz-f1^hs.PM is induced at 4 or 5hr APF, but 75 or 100% of animals become pupa at 12.3 or 12.6 APF on average when ftz-f1^hs.PM is induced at 6 or 7hr APF, respectively.

(Akagi et al., 2016)

ftz-f1^hs.PM rescues ftz-f1^ex7/ftz-f1⁰³⁶⁴⁹ animals that are arrested as prepupae before stage P4; the rescued animals are able to become pupae and a fraction of them develop until at least stage P12. Efficient rescue is seen when the animals are heat shocked 6-10 hours after puparium formation.

(Yamada et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11598

P{PZ}ftz-f1⁰³⁶⁴⁹ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: l(3)00864⁰⁰⁸⁶⁴.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ftz-f1⁰³⁶⁴⁹

(Sultan et al., 2014, Gradilla et al., 2011, Christensen et al., 2009.7.22, Christensen et al., 2009.7.22, Christensen et al., 2008.4.15)

ftz-f1^l(3)03649

(Akagi et al., 2016, Akagi et al., 2013, Bowler et al., 2006, Argiropoulos et al., 2003)

l(3)03649

(Kawasaki et al., 2002, Yamada et al., 2000, Spradling et al., 1999, Maixner et al., 1998)

l(3)03649⁰³⁶⁴⁹

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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