Allele Dmel\sr⁰³⁹⁹⁹

General Information
Symbol	Dmel\sr⁰³⁹⁹⁹	Species	D. melanogaster
Name		FlyBase ID	FBal0009498
Feature type	allele	Associated gene	Dmel\sr
Also Known As	l(3)03999, sr^P1618

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (Lindsley and Zimm, 1992, Frommer et al., 1996, Beiman et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:13,947,657..13,947,657 (Frommer et al., 1996, BDGP Project Members, 1994-1999, Lindsley and Zimm, 1992, Dorfman et al., 2002, Ghazi et al., 2000, Usui et al., 2004, Hatini and DiNardo, 2001, Beiman et al., 1996, Spradling et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{PZ} insertion into an intron. (Beiman et al., 1996) P{PZ} insertion within the intron that separates the different 5' regions from the common 3' region of transcripts sra and srb. (Frommer et al., 1996)
Caused by insertion	P{PZ}sr⁰³⁹⁹⁹ (Frommer et al., 1996, BDGP Project Members, 1994-1999, Lindsley and Zimm, 1992, Dorfman et al., 2002, Ghazi et al., 2000, Usui et al., 2004, Hatini and DiNardo, 2001, Beiman et al., 1996, Spradling et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Phenotype Manifest In

Detailed Description
	Statement Reference Semi-lethal. (Frommer et al., 1996)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference sr⁰³⁹⁹⁹ has adult epidermis phenotype, enhanceable by ap⁴/ap⁴ (Ghazi et al., 2000) sr⁰³⁹⁹⁹ has mesothoracic tergum phenotype, enhanceable by ap⁴/ap⁴ (Ghazi et al., 2000)
Enhancer of
Statement Reference sr⁰³⁹⁹⁹/sr⁰³⁹⁹⁹ is an enhancer of indirect flight muscle phenotype of ap⁴ (Ghazi et al., 2000, Ghazi et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference A significant proportion of ap⁴/ap⁴, sr⁰³⁹⁹⁹/sr⁰³⁹⁹⁹ flies show an enhanced IFM mutant phenotype and a dark midnotal stripe characteristic of strong sr mutants. (Ghazi et al., 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	sr^06915b (BDGP Project Members, 1994-1999) sr^06948b (BDGP Project Members, 1994-1999)
Comments
Stocks ( 1 )
Bloomington	11618 ry⁵⁰⁶ P{PZ}sr⁰³⁹⁹⁹/TM3, ry^RK Sb¹ Ser¹
Notes on Origin
Discoverer	A. Spradling.

Comments
	Δ2-3 mobilisation of the P{PZ} insertion causing a precise excision reverts the mutant phenotype to wild type. (Frommer et al., 1996) Complements: l(3)00643⁰⁰⁶⁴³. Complements: l(3)05697⁰⁵⁶⁹⁷. Complements: Ssdp^neo48. Fails to complement: l(3)00643^s2541. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	l(3)03999 (Usui et al., 2004, Dorfman et al., 2002, Spradling et al., 1999) l(3)03999⁰³⁹⁹⁹ (Lindsley and Zimm, 1992) sr⁰³⁹⁹⁹ sr^P1618 (Inbal et al., 2004, Beiman et al., 1996)
Name Synonym
Secondary FlyBase IDs

References ( 12 )
Research paper	Inbal et al., 2004, Dev. Cell 7(2): 241--250 Recruitment of ectodermal attachment cells via an EGFR-dependent mechanism during the organogenesis of Drosophila proprioceptors. [FBrf0180120] Usui et al., 2004, Curr. Biol. 14(12): 1047--1055 Mutual exclusion of sensory bristles and tendons on the notum of dipteran flies. [FBrf0179495] Dorfman et al., 2002, Dev. Biol. 252(1): 119--126 Stripe provides cues synergizing with branchless to direct tracheal cell migration. [FBrf0155479] Hatini and DiNardo, 2001, Mol. Cell 7(1): 151--160 Distinct signals generate repeating striped pattern in the embryonic parasegment. [FBrf0134763] Ghazi et al., 2000, Development 127(24): 5309--5318 Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cues. [FBrf0131298] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Beiman et al., 1996, Genes Dev. 10(23): 2993--3002 Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. [FBrf0090449] Frommer et al., 1996, EMBO J. 15(7): 1642--1649 Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance. [FBrf0087142]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\sr03999

Allele Dmel\sr⁰³⁹⁹⁹