FlyBase Allele Report: Dmel\HDAC1[04556]

General Information

Symbol

Dmel\HDAC1⁰⁴⁵⁵⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0009513

Feature type

allele

Associated gene

Dmel\HDAC1

Associated Insertion(s)

P{PZ}HDAC1⁰⁴⁵⁵⁶

Carried in Construct

Also Known As

rpd3⁰⁴⁵⁵⁶, l(3)04556, rpd3^P-UTR, P{PZ}Rpd3⁰⁴⁵⁵⁶

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Rogina et al., 2002, Mottus et al., 2000)

loss of function allele

(Chen et al., 1999)

Mutagen

P-element activity

(Mannervik and Levine, 1999)

Progenitor genotype

Associated Insertion(s)

P{PZ}HDAC1⁰⁴⁵⁵⁶

Cytology

Description

FlyBase curator comment: Authors of FBrf0111344 state that P-element insertion is 47bp from the transcription start site, however see FBrf0108900 for authoritative statement of lesion.

(Chen et al., 1999)

P{PZ} is inserted at nucleotide 47 in the 223bp long 5' UTR of Rpd3.

(Mannervik and Levine, 1999)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:4,626,763..4,626,763 [+]

(Lenz et al., 2021, Kopp et al., 2015, Joyce et al., 2011, Branco et al., 2008, Chen et al., 2008, McClure and Schubiger, 2008, Singh et al., 2005, Collins and Treisman, 2000, Fernandez-Funez et al., 2000, Chen et al., 1999, Mannervik and Levine, 1999, Spradling et al., 1999, Maixner et al., 1998, Russell et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

ameliorates cancer

modeled by Delta^UAS.cDa, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

exacerbates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

ameliorates ataxia telangiectasia

modeled by tefu^RNAi.UAS

(Rimkus et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response | adult stage

(Kopp et al., 2015)

lethal | recessive

(Mottus et al., 2000, Spradling et al., 1999, Russell et al., 1998, Perrimon et al., 1996)

lethal - all die during embryonic stage | germline clone

(Mannervik and Levine, 1999)

lethal - all die during embryonic stage | germline clone | recessive

(Chen et al., 1999)

long lived

(Kopp et al., 2015)

long lived | dominant | female

(Rogina et al., 2002)

long lived | dominant | male

(Rogina et al., 2002)

pair rule phenotype

(Russell et al., 1998)

pair rule phenotype | embryonic stage | germline clone

(Mannervik and Levine, 1999)

pair rule phenotype | embryonic stage | germline clone | recessive

(Chen et al., 1999)

pair rule phenotype | germline clone

(Chen et al., 1999, Mannervik and Levine, 1999)

pair rule phenotype | maternal effect

(Perrimon et al., 1996)

partially lethal - majority die

(Chang et al., 2001)

partially lethal - majority die | nutrition conditional (with HDAC1³⁰³)

(Mottus et al., 2000)

partially lethal - majority die | nutrition conditional (with HDAC1³¹³)

(Mottus et al., 2000)

partially lethal - majority die | nutrition conditional (with HDAC1³²⁶)

(Mottus et al., 2000)

partially lethal - majority die | nutrition conditional (with HDAC1³²⁸)

(Mottus et al., 2000)

partially lethal - majority die | recessive

(Berkeley Drosophila Genome Project, 1993.6.1)

short lived | nutrition conditional (with HDAC1³⁰³)

(Mottus et al., 2000)

short lived | nutrition conditional (with HDAC1³¹³)

(Mottus et al., 2000)

short lived | nutrition conditional (with HDAC1³²⁶)

(Mottus et al., 2000)

short lived | nutrition conditional (with HDAC1³²⁸)

(Mottus et al., 2000)

some die during embryonic stage | germline clone

(Mannervik and Levine, 1999)

some die during embryonic stage | maternal effect

(Perrimon et al., 1996)

some die during embryonic stage | recessive

(Chen et al., 1999)

suppressor of variegation | recessive, with In(1)w^m4

(Mottus et al., 2000)

visible | drug conditional

(Pile et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

HDAC1⁰⁴⁵⁵⁶ heterozygote adults have increased lifespan and increased survival under paraquat-induced oxidative stress, as compared to wild-type controls.

(Kopp et al., 2015)

Rpd3⁰⁴⁵⁵⁶ germline clones exhibit an abundance of γ-His2Av foci and evidence of a repair defect.

(Joyce et al., 2011)

Rpd3⁰⁴⁵⁵⁶/+ flies have the normal number of dorsocentral bristles.

(Biryukova and Heitzler, 2008)

Similarly to wild-type controls, Rpd3⁰⁴⁵⁵⁶/+ heterozygotes show an age-dependent increase in susceptibility to temperature-sensitive paralysis.

(Reenan and Rogina, 2008)

Heterozygotes have no effect on the position effect variegation of w seen in the In(1)w^m4h chromosome.

(Zhao et al., 2008)

Heterozygous males show a 33% extension of life-span. Heterozygous females show a 52% extension of life-span. Calorific restriction does not result in a further extension of life-span in Rpd3⁰⁴⁵⁵⁶ heterozygotes.

(Rogina et al., 2002)

Heterozygotes raised on medium containing trichostatin A (TSA) do not show an increase in the rate of lethality or developmental delay compared to wild-type flies raised on medium containing TSA and in fact the lethality caused by TSA is weakly suppressed in heterozygotes compared to wild type. Heterozygotes raised on medium containing trichostatin A (TSA) have a notched wing phenotype, with the notches increasing in number and size with increasing TSA concentration.

(Pile et al., 2001)

HDAC1⁰⁴⁵⁵⁶ homozygotes are lethal; HDAC1⁰⁴⁵⁵⁶/HDAC1³⁰³, HDAC1⁰⁴⁵⁵⁶/HDAC1³¹³, HDAC1⁰⁴⁵⁵⁶/HDAC1³²⁶ and HDAC1⁰⁴⁵⁵⁶/HDAC1³²⁸ transheterozygotes are lethal under normal conditions, but the rare adults eclose and survive to short-lived and sterile adults in uncrowded yeast-supplemented conditions. When raised under carefully maintained culture conditions transheterozygotes of the genotype HDAC1⁰⁴⁵⁵⁶/HDAC1³⁰³ adult males eclose at 40% the expected rate and females at 30% the expected rate. Adults are short lived and females produce few eggs, apparently unfertilised. HDAC1⁰⁴⁵⁵⁶ has no dominant effect on PEV. Phenotypes include strong suppression of variegation in In(1)w^m4, severely notched wings, small, malformed, sometimes curved or duplicated bristles, alulae that are larger than normal, and a reduction in the number of sex combs.

(Mottus et al., 2000)

Embryos from mosaic females containing Rpd3⁰⁴⁵⁵⁶ homozygous germ-line clones, exhibit a pair rule phenotype in more than 80% of the majority (>65%) that fail to hatch. Partial or complete fusion of adjacent denticle belts are seen, resulting in embryos with 5 to 8 thoracic and abdominal segments. In addition variable, often severe, defects are seen in the head skeleton.

(Chen et al., 1999)

Embryos derived from Rpd3⁰⁴⁵⁵⁶ germline clones exhibit a variable pair-rule phenotype. They are also reduced in size.

(Mannervik and Levine, 1999)

Embryos derived from homozygous female germ line clones show a weak maternal effect, having pair rule segment defects.

(Russell et al., 1998)

Germline clones produce eggs with patterning defects: variable pair-rule segmentation defects.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has visible | dominant phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has visible | dominant phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

Enhancer of

Statement

Reference

HDAC1⁰⁴⁵⁵⁶ is an enhancer of visible phenotype of Iswi^{K159R.UAS.Tag:HA}, Scer\GAL4^ey.PH

(Burgio et al., 2008)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of visible | dominant phenotype of hep^CA

(Miotto et al., 2006)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of visible | dominant phenotype of Snr1^E1

(Zraly et al., 2004)

Suppressor of

Statement

Reference

HDAC1⁰⁴⁵⁵⁶ is a suppressor of visible phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Anderson et al., 2011)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is a suppressor of neoplasia phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is a suppressor of visible phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

HDAC1⁰⁴⁵⁵⁶ is a suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

HDAC1⁰⁴⁵⁵⁶, Scer\GAL4^DJ651 is a suppressor of short lived phenotype of Ctet\tetX^TNT-LC.UAS, Scer\GAL4^DJ651

(Bauer et al., 2004)

HDAC1⁰⁴⁵⁵⁶/HDAC1[+] is a suppressor of partially lethal phenotype of Scer\GAL4^nanos.PG, run^UAS.cLa

(Wheeler et al., 2002)

HDAC1⁰⁴⁵⁵⁶ is a suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Other

Statement

Reference

HDAC1⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has visible | dominant phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+], Snr1^R3 has visible phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has visible | dominant phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, gro^E48 has lethal | dominant | maternal effect | embryonic stage phenotype

(Chen et al., 1999)

Df(3R)Espl22, HDAC1⁰⁴⁵⁵⁶ has lethal | dominant | maternal effect | embryonic stage phenotype

(Chen et al., 1999)

HDAC1⁰⁴⁵⁵⁶, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

HDAC1⁰⁴⁵⁵⁶ has sex comb phenotype, non-enhanceable by esc¹⁰

(Chang et al., 2001)

HDAC1⁰⁴⁵⁵⁶ has sex comb phenotype, non-enhanceable by E(z)⁶³

(Chang et al., 2001)

Suppressed by

Statement

Reference

HDAC1⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has wing phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has wing vein | ectopic phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has wing vein | ectopic phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has wing phenotype, suppressible | partially by brm²

(Zraly et al., 2004)

NOT suppressed by

Statement

Reference

HDAC1⁰⁴⁵⁵⁶ has sex comb phenotype, non-suppressible by E(z)⁶³

(Chang et al., 2001)

HDAC1⁰⁴⁵⁵⁶ has sex comb phenotype, non-suppressible by esc¹⁰

(Chang et al., 2001)

Enhancer of

Statement

Reference

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of dorsocentral bristle | increased number phenotype of pnr^D1

(Biryukova and Heitzler, 2008)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

HDAC1⁰⁴⁵⁵⁶ is an enhancer of eye phenotype of Iswi^{K159R.UAS.Tag:HA}, Scer\GAL4^ey.PH

(Burgio et al., 2008)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of wing phenotype of hep^CA

(Miotto et al., 2006)

HDAC1⁰⁴⁵⁵⁶ is an enhancer of embryonic head | maternal effect phenotype of Bin1^R7-18, bcd⁶

(Singh et al., 2005)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of wing vein | ectopic phenotype of net¹

(Marenda et al., 2004)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is an enhancer of wing phenotype of Snr1^E1

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶ is an enhancer of sex comb phenotype of Pc⁴

(Chang et al., 2001)

HDAC1⁰⁴⁵⁵⁶ is an enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

HDAC1⁰⁴⁵⁵⁶ is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT Enhancer of

Statement

Reference

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is a non-enhancer of retina phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

HDAC1⁰⁴⁵⁵⁶ is a non-enhancer of sex comb phenotype of esc¹⁰

(Chang et al., 2001)

HDAC1⁰⁴⁵⁵⁶ is a non-enhancer of sex comb phenotype of E(z)⁶³

(Chang et al., 2001)

Suppressor of

Statement

Reference

HDAC1⁰⁴⁵⁵⁶ is a suppressor of eye phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Anderson et al., 2011)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, tefu^RNAi.UAS

(Rimkus et al., 2008)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4^GMR.PU, tefu^RNAi.UAS

(Rimkus et al., 2008)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is a suppressor of eye phenotype of Delta^UAS.cDa, Scer\GAL4^ey.PH, lola^GS88A8, psq^GS88A8

(Ferres-Marco et al., 2006)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is a suppressor of adult thorax | pharate adult stage phenotype of chm¹⁴

(Miotto et al., 2006)

HDAC1⁰⁴⁵⁵⁶ is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

NOT Suppressor of

Statement

Reference

HDAC1⁰⁴⁵⁵⁶ is a non-suppressor of sex comb phenotype of E(z)⁶³

(Chang et al., 2001)

HDAC1⁰⁴⁵⁵⁶ is a non-suppressor of sex comb phenotype of esc¹⁰

(Chang et al., 2001)

HDAC1⁰⁴⁵⁵⁶/Rpd3[+] is a non-suppressor of eye phenotype of Scer\GAL4^hs.2sev, ttk^{69.UAS.Tag:HA}

(Wen et al., 2000)

Other

Statement

Reference

Gug^RNAi.1.UAS, HDAC1⁰⁴⁵⁵⁶, Scer\GAL4^dpp.blk1 has adult head phenotype

(Wang et al., 2008)

Gug^RNAi.1.UAS, HDAC1⁰⁴⁵⁵⁶, Scer\GAL4^dpp.blk1 has melanotic mass phenotype

(Wang et al., 2008)

HDAC1⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has wing phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^E1/Snr1[+] has wing vein | ectopic phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3 has wing phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3 has wing vein | ectopic phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has wing phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, Snr1^R3/Snr1[+] has wing vein | ectopic phenotype

(Zraly et al., 2004)

HDAC1⁰⁴⁵⁵⁶, gro^E48 has embryonic epidermis phenotype

(Chen et al., 1999)

HDAC1⁰⁴⁵⁵⁶, gro^E48 has embryo phenotype

(Chen et al., 1999)

Df(3R)Espl22, HDAC1⁰⁴⁵⁵⁶ has embryonic epidermis phenotype

(Chen et al., 1999)

Df(3R)Espl22, HDAC1⁰⁴⁵⁵⁶ has embryo phenotype

(Chen et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The disorganised eye phenotype caused by expression of sens^Scer\UAS.cNa under the control of Scer\GAL4^lz-gal4 is suppressed by Rpd3⁰⁴⁵⁵⁶.

(Anderson et al., 2011)

Rpd3⁰⁴⁵⁵⁶/+ enhances the phenotype of pnr^D1/+, resulting in extra dorsocentral sensory organs.

(Biryukova and Heitzler, 2008)

The severity of the mutant eye phenotype caused by expression of Iswi^{K159R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ey.PH is enhanced by Rpd3⁰⁴⁵⁵⁶.

(Burgio et al., 2008)

Rpd3⁰⁴⁵⁵⁶/+ suppresses the rough-eye phenotype and increases the number of normal photoreceptors per ommatidium in flies expressing tefu^{dsRNA.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Rimkus et al., 2008)

6.1% of Rpd3⁰⁴⁵⁵⁶ mutant males expressing Gug^{dsRNA.1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 develop melanotic masses in their heads.

(Wang et al., 2008)

Rpd3⁰⁴⁵⁵⁶ dominantly suppresses the eye tumour phenotype of flies expressing Dl^Scer\UAS.cDa under the control of Scer\GAL4^ey.PH and also carrying the P{GSV1}lola^GS88A8 insertion (which results in the lola^GS88A8 and psq^GS88A8 alleles being expressed under the control of Scer\GAL4^ey.PH).

(Ferres-Marco et al., 2006)

The severity of the thoracic cleft seen in chm¹⁴ pharate adults is suppressed by heterozygosity for Rpd3⁰⁴⁵⁵⁶.

(Miotto et al., 2006)

Progeny from Bin1^R7-18, Bin1^R7-18/Rpd3⁰⁴⁵⁵⁶ mothers show high levels of lethality (>50%) with nearly all of the unhatched embryos, more than a third of the hatched larvae display head defects. Most are missing the labrum, epistomal sclerite and dorsal and ventral arms are reduced in size.

(Singh et al., 2005)

The lifespan of males expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^DJ651 is significantly extended if they also carry Rpd3⁰⁴⁵⁵⁶. The lifespan of females expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^DJ651 is significantly extended if they also carry Rpd3⁰⁴⁵⁵⁶.

(Bauer et al., 2004)

At 29^oC, Rpd3⁰⁴⁵⁵⁶/+ enhances the ectopic wing vein phenotype of Snr1^E1/+; 61% have an ectopic vein emanating from the posterior crossvein and 39% have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. Rpd3⁰⁴⁵⁵⁶/Snr1^R3 double heterozygotes have wing vein defects; 32% have normal wings, 38% have an ectopic vein emanating from the posterior crossvein and 30% have ectopic veins emanating from the posterior crossvein and posterior to the L5 longitudinal vein. Rpd3⁰⁴⁵⁵⁶/brm² double heterozygotes have a normal wing phenotype. The ectopic wing vein phenotype seen in Rpd3⁰⁴⁵⁵⁶/Snr1^R3 and Rpd3⁰⁴⁵⁵⁶/Snr1^E1 double heterozygotes at 29^oC is partially suppressed by brm²/+.

(Zraly et al., 2004)

Sir2^05327a does not show a dominant synthetic lethal interaction with Rpd3⁰⁴⁵⁵⁶.

(Rosenberg and Parkhurst, 2002)

The partial lethality due to run^Scer\UAS.cLa; Scer\GAL4^nos.PG (3% viable) is partially suppressed by maternal heterozygosity for Rpd3⁰⁴⁵⁵⁶ (rescues to 31% viable).

(Wheeler et al., 2002)

The addition of Pc⁴ to Rpd3⁰⁴⁵⁵⁶ animals increases the average number of extra sex comb teeth per leg from 2.7 to 3.94. The addition of esc¹⁰ or E(z)⁶³ to Rpd3⁰⁴⁵⁵⁶ animals has no effect on the extra sex comb phenotype.

(Chang et al., 2001)

The eye phenotype caused by expression of ttk^{69.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.2sev is not dramatically modulated by Rpd3⁰⁴⁵⁵⁶.

(Wen et al., 2000)

Eggs from Rpd3⁰⁴⁵⁵⁶/gro^E48 mothers exhibit an embryonic lethality significantly higher than from either gro^E48/+ or Rpd3⁰⁴⁵⁵⁶/+ mothers. Cuticles from over 70% of unhatched embryos show a bicaudal phenotype, including a duplicated posterior spiracle, and a mirror image duplication of the posterior abdominal segments in place of the normal anterior segments. Eggs from Rpd3⁰⁴⁵⁵⁶/Df(3R)Espl22 mothers exhibit an embryonic lethality significantly higher than from either Df(3R)Espl22/+ or Rpd3⁰⁴⁵⁵⁶/+ mothers. Cuticles from over 70% of unhatched embryos show a bicaudal phenotype, including a duplicated posterior spiracle, and a mirror image duplication of the posterior abdominal segments in place of the normal anterior segments.

(Chen et al., 1999)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by Rpd3⁰⁴⁵⁵⁶.

(Maixner et al., 1998)

Xenogenetic Interactions

Statement

Reference

One copy of Rpd3⁰⁴⁵⁵⁶ does not enhance the retinal phenotype seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Rpd3⁰⁴⁵⁵⁶ enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Branco et al., 2008)

The decreased lifespan of males expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^DJ651 is significantly suppressed if they also carry HDAC1⁰⁴⁵⁵⁶. The decreased lifespan of females expressing Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^DJ651 is significantly suppressed if they also carry HDAC1⁰⁴⁵⁵⁶.

(Bauer et al., 2004)

Complementation and Rescue Data

Fails to complement

HDAC1³⁰³

(Mottus et al., 2000)

HDAC1³¹³

(Mottus et al., 2000)

HDAC1³²⁸

(Mottus et al., 2000)

HDAC1³²⁶

(Mottus et al., 2000)

Comments

Fails to complement Rpd3³⁰³, Rpd3³¹³, Rpd3³²⁶ and Rpd3³²⁸ for viability.

(Mottus et al., 2000)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11633

P{PZ}HDAC1⁰⁴⁵⁵⁶ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: l(3)02624⁰²⁶²⁴. Complements: l(3)rI165^rI165. Complements: l(3)rI327^rI327.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

Drpd3⁰⁴⁵⁵⁶

(Miotto et al., 2006)

HDAC1⁰⁴⁵⁵⁶

(Lenz et al., 2021, Biryukova and Heitzler, 2008)

Hdac^P-UTR

(Chang et al., 2001)

P-UTR

(Mottus et al., 2000)

P1633

(Chen et al., 1999)

RPD3⁰⁴⁵⁵⁶

(Rimkus et al., 2008)

Rpd3⁰⁴⁵⁵⁶

(Muraoka et al., 2021, Ito et al., 2012, Anderson et al., 2011, Walrad et al., 2011, Walrad et al., 2010, Branco et al., 2008, Burgio et al., 2008, Cao et al., 2008, Chen et al., 2008, Pallos et al., 2008, Wang et al., 2008, Zhao et al., 2008)

Rpd³⁰⁴⁵⁵⁶

(Rosenberg and Parkhurst, 2002)

l(3)04556

(Pile et al., 2001, Spradling et al., 1999, Maixner et al., 1998, Russell et al., 1998)

l(3)04556⁰⁴⁵⁵⁶

(Singh et al., 2005)

rpd3⁰⁴⁵⁵⁶

(Kopp et al., 2015, Moshkin et al., 2009, McClure and Schubiger, 2008, Struffi and Arnosti, 2005)

rpd3^P-UTR

(Reenan and Rogina, 2008, Bauer et al., 2004, Rogina et al., 2002)

rpd^-

(Singh et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (48)

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