A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Hmgcr04684

General Information
SymbolDmel\Hmgcr04684SpeciesD. melanogaster
NameFlyBase IDFBal0009515
Feature typealleleAssociated geneDmel\Hmgcr
Map ( GBrowse ) Untitled Document detailed view FBti0004269 FBti0039200 FBti0132696 FBti0047941 FBti0056063 FBti0108351 FBti0099960 FBti0100949 FBti0024733 FBti0040121 FBti0005505 FBti0077962 FBti0065083 FBti0005515
Allele class
MutagenP-element activity
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Description
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FB2013_03
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hide Nature of the Allele
Allele class
Mutagen
P-element activity
 
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
transposable element insertion site
3R:19,583,339..19,583,339
 
(BDGP Project Members, 1994-1999, Spradling et al., 1999, Belgacem and Martin, 2007)
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
 
 
Caused by insertion
P{PZ}Hmgcr04684
(BDGP Project Members, 1994-1999, Spradling et al., 1999, Belgacem and Martin, 2007)
Cytology
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hide Phenotypic Class
developmental rate defective | cold sensitive
(Belgacem and Martin, 2007)
lethal | heat sensitive
(Belgacem and Martin, 2007)
lethal | recessive
(Spradling et al., 1999)
locomotor rhythm defective
(Belgacem and Martin, 2007)
partially lethal - majority die
 
partially lethal - majority die | recessive
(Berkeley Drosophila Genome Project, 1993.6.1)
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Statement
Reference
Hmgcr[04684] homozygotes are lethal when raised at 24[o]C. However, when reared at 19[o]C, 5 and 10% of males and females, respectively, which are developmentally delayed, attempt to survive until adulthood. Quantification of the locomotor activity of these flies indicates that the start/stop number for both sexes is the same. Hmgcr[04684] heterozygotes exhibit a wild-type phenotype.
(Belgacem and Martin, 2007)
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Linkouts
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hide Genetic Interactions
Statement
Reference
hide Xenogenetic Interactions
Statement
Reference
hide Complementation & Rescue Data
Rescued by
Hmgcr04684 is rescued by Scer\GAL4da.G32/HmgcrScer\UAS.cvDa
(Belgacem and Martin, 2007)
Hmgcr04684 is rescued by Scer\GAL4Scer\FRT.Act5C/Scer\GAL4Hmgcr.B/HmgcrScer\UAS.cvDa
(Belgacem and Martin, 2007)
Partially rescued by
Hmgcr04684 is partially rescued by Scer\GAL4Scer\FRT.Act5C/HmgcrScer\UAS.cvDa
(Belgacem and Martin, 2007)
Not rescued by
Hmgcr04684 is not rescued by Scer\GAL4elav-C155/HmgcrScer\UAS.cvDa
(Belgacem and Martin, 2007)
Hmgcr04684 is not rescued by Scer\GAL4to.PD/HmgcrScer\UAS.cvDa
(Belgacem and Martin, 2007)
Comments
Expression of Hmgcr[Scer\UAS.cvDa] under the control of Scer\GAL4[elav-C155] or Scer\GAL4[to.PD] fails to rescue the lethality found in Hmgcr[04684] homozygotes. Expression of Hmgcr[Scer\UAS.cvDa] under the control of Scer\GAL4[Scer\FRT.Act5C] completely rescues lethality, but does not rescue the sexual dimorphism. Expression of Hmgcr[Scer\UAS.cvDa] under the control of Scer\GAL4[da.G32] is sufficient to rescue both the lethality (partly in males - 75%, and completely in females) and the start/stop number (indicating locomotor activity). Targeted expression of Hmgcr[Scer\UAS.cvDa] under the control of Scer\GAL4[Scer\FRT.Act5C] and Scer\GAL4[Hmgcr.B] is sufficient to rescue the sexual dimorphism.
(Belgacem and Martin, 2007)
hide Stocks ( 1 )
Bloomington
11635
ry506 P{PZ}Hmgcr04684/TM3, ryRK Sb1 Ser1
hide Notes on Origin
Discoverer
A. Spradling.
hide Comments
Complements: Hmgcr01152. Complements: l(3)0690606906.
(BDGP Project Members, 1994-1999)
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Other Crossreferences
Linkouts
hide Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym
Hmgcr04684
 
hmgcr11635
(Belgacem and Martin, 2007)
l(3)04684
(Spradling et al., 1999)
l(3)0468404684
 
Name Synonym
Secondary FlyBase IDs
hide References ( 6 )
Research paper
Belgacem and Martin, 2007, PLoS ONE 2(1): e187
Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila. [FBrf0192310]
Spradling et al., 1999, Genetics 153(1): 135--177
The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Erickson et al., 1997, J. Cell Biol. 138(3): 589--603
Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. [FBrf0094649]
Personal communication to FlyBase
Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington.
lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714]
BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file)
BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Berkeley Drosophila Genome Project, 1993.6.1, Insertion alleles.
Insertion alleles. [FBrf0122635]