FlyBase Allele Report: Dmel\hid[05014]

(Bhaskar et al., 2014, Davidson and Duronio, 2012, Suissa et al., 2011, Zhang et al., 2008, Wells et al., 2006, Adachi-Yamada et al., 2005, Cullen and McCall, 2004, Chandrasekaran and Beckendorf, 2003, Jassim et al., 2003, Shi et al., 2003, Spradling et al., 1999, Grether et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage (with Df(3L)H99)

(Lee et al., 2013)

decreased cell death (with hid^rvX1)

(Cordero et al., 2004)

decreased cell death | adult stage (with Df(3L)H99)

(Lee et al., 2013)

decreased cell death | dominant | third instar larval stage

(Brodsky et al., 2004)

decreased cell death | recessive

(Moon et al., 2008)

decreased cell death | third instar larval stage | conditional

(Wang et al., 2013)

lethal | recessive

(Spradling et al., 1999, Grether et al., 1995)

lethal - all die before end of P-stage

(Wang et al., 2008)

lethal - all die during embryonic stage (with Df(3L)H99)

(Choi et al., 2006)

lethal - all die during embryonic stage | recessive

(Cox et al., 2000)

radiation resistant | oogenesis

(Park et al., 2019)

some die during embryonic stage (with Df(3L)H99)

(Choi et al., 2006)

some die during embryonic stage | recessive

(Cox et al., 2000)

some die during P-stage

(Wang et al., 2008)

visible (with Df(3L)H99)

(Krieser et al., 2007)

visible | male (with Df(3L)H99)

(Krieser et al., 2007)

Phenotype Manifest In

arista (with Df(3L)H99)

(Cullen and McCall, 2004)

arista lateral | ectopic (with Df(3L)H99)

(Cullen and McCall, 2004)

dorsal fold

(Grether et al., 1995)

embryo | dorsal closure stage

(Cox et al., 2000)

embryonic/larval salivary gland

(Wang et al., 2008)

embryonic head

(Grether et al., 1995)

eye disc

(Moon et al., 2008)

eye disc (with Df(3L)H99)

(Krieser et al., 2007)

eye disc (with hid^rvX1)

(Cordero et al., 2004)

female germline cell | oogenesis

(Park et al., 2019)

germarium | oogenesis

(Park et al., 2019)

male genitalia (with Df(3L)H99)

(Krieser et al., 2007)

ommatidial precursor cluster (with hid^rvX1)

(Cordero et al., 2004)

peptidergic neuron | adult stage | ectopic (with Df(3L)H99)

(Lee et al., 2013)

spermatid (with Df(3L)H99)

(Huh et al., 2004)

wing (with Df(3L)H99)

(Krieser et al., 2007)

wing disc | third instar larval stage

(Brodsky et al., 2004)

wing disc | third instar larval stage | conditional

(Wang et al., 2013)

Detailed Description

Statement

Reference

Under normal conditions hid⁰⁵⁰¹⁴ adults do not exhibit any changes in cell death in germarium compared to controls. 6 hours after 3 or 40 Gy irradiation they do not exhibit an increase in cell death in germarium compared to untreated adults, different than controls.

(Park et al., 2019)

Homozygous and W⁰⁵⁰¹⁴/Df(3L)X14 animals do not show a defect in the programmed cell death of vCrz neurons: the neurons are no longer present at 7 hours after puparium formation, as occurs in wild-type.

(Lee et al., 2013)

As in wild type, W⁰⁵⁰¹⁴/Df(3L)X14 mutant bursCCAP neurons undergo programmed cell death shortly after eclosion.

The programmed cell death of bursCCAP neurons seen in the adult ventral nerve cord of wild type flies after eclosion is suppressed to a similar extent in W⁰⁵⁰¹⁴/Df(3L)H99 and Df(3L)H99/+ mutant flies.

(Lee et al., 2013)

Wild type larval wing discs show two phases of apoptosis in response to irradiation: first signs of cell death are clear after 4h and plateau, with cell death again increasing from 16-24h; irradiated hid⁰⁵⁰¹⁴ discs show significantly less apoptosis at 4h compared to wild type, and show a similar second phases of induction at 16-24h but at significantly lower levels.

(Wang et al., 2013)

In contrast to wild-type controls, DNA-damage induced apoptosis is completely abolished in homozygous W⁰⁵⁰¹⁴ mutant eye discs.

(Moon et al., 2008)

Mutants show defects in destruction of the larval salivary glands, having persistant larval salivary glands at the pupal stage.

(Wang et al., 2008)

W⁰⁵⁰¹⁴/Df(3L)H99 males have a rotated genitalia defect. 100% of W⁰⁵⁰¹⁴/Df(3L)H99 flies have a ballooned wing phenotype.

W⁰⁵⁰¹⁴/Df(3L)H99 animals have extra interommatidial cells in the pupal eye disc.

(Krieser et al., 2007)

Most W⁰⁵⁰¹⁴/Df(3L)H99 (or Df(3L)X14) mutants are embryonic lethal, with only a few escapers.

W⁰⁵⁰¹⁴/Df(3L)H99 and W⁰⁵⁰¹⁴/Df(3L)X14 mutants exhibit normal levels of programmed cell death in Crz-expressing neurons of the ventral nerve cord.

(Choi et al., 2006)

The wing discs of W⁰⁵⁰¹⁴/+ mutant third instar larvae exhibit reduced levels of apoptosis in response to X-ray induced irradiation with 4000 rads compared to controls.

(Brodsky et al., 2004)

W⁰⁵⁰¹⁴/W^rvX1 pupal eye discs lack any evidence of "early stage" cell death (this normally occurs between 18-24 hours after puparium formation). The ommatidia in these pupal retinas are disorganised compared to wild type due to the excess of cells present. The retinas often appear to be attached to what seems to be the antennal disc in the pupae.

(Cordero et al., 2004)

W⁰⁵⁰¹⁴/Df(3L)H99 mutant animals exhibit ectopic branching on their aristae.

(Cullen and McCall, 2004)

cysts from W⁰⁵⁰¹⁴/Df(3L)H99 mutant male testes, show defects in spermatid individualisation.

(Huh et al., 2004)

The level of photoreceptor apoptosis at the periphery of developing eyes at 42 hours after puparium formation is reduced, but not eliminated, in W⁰⁵⁰¹⁴ homozygous clones.

(Lin et al., 2004)

Homozygous embryos have defects in head involution but their segment polarity is normal.

(Cox et al., 2000)

Pronounced defect in the morphogenetic movements of head involution which results, in part, from a failure of the dorsal fold to migrate anteriorly. Otherwise the segmented cuticle is normal and individuals reach advanced stages. There is less apoptosis when compared to wild type, most noticeably in the head region prior to completion of head involution.

(Grether et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

hid⁰⁵⁰¹⁴ has decreased cell death | third instar larval stage | conditional phenotype, non-enhanceable by Clbn^1Q/Clbn^1Q

(Wang et al., 2013)

hid⁰⁵⁰¹⁴ has decreased cell death | recessive phenotype, non-enhanceable by Rbf^120a

(Moon et al., 2008)

Suppressed by

Statement

Reference

hid⁰⁵⁰¹⁴/Df(3L)H99, Ras85D^KP has visible phenotype, suppressible by hep^NIG.4353R/Scer\GAL4^GMR.PF

(Wu et al., 2009)

NOT suppressed by

Statement

Reference

hid⁰⁵⁰¹⁴ has decreased cell death | third instar larval stage | conditional phenotype, non-suppressible by Clbn^1Q/Clbn^1Q

(Wang et al., 2013)

hid⁰⁵⁰¹⁴ has decreased cell death | recessive phenotype, non-suppressible by Rbf^120a

(Moon et al., 2008)

NOT Enhancer of

Statement

Reference

hid⁰⁵⁰¹⁴ is a non-enhancer of decreased cell death | third instar larval stage | conditional phenotype of Clbn^1Q

(Wang et al., 2013)

Suppressor of

Statement

Reference

hid⁰⁵⁰¹⁴/Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

hid⁰⁵⁰¹⁴ is a suppressor of increased cell death | third instar larval stage phenotype of Clbn^UAS.cWa

(Wang et al., 2013)

hid⁰⁵⁰¹⁴/W[+] is a suppressor | partially of abnormal cell death | third instar larval stage phenotype of E2f1^{PIP-3A-DBD.UASp.EGFP}, Scer\GAL4^en-e16E

(Davidson and Duronio, 2012)

hid⁰⁵⁰¹⁴ is a suppressor of increased cell death phenotype of Scer\GAL4^ap-nd432, nab^EP-nd642

(Suissa et al., 2011)

hid⁰⁵⁰¹⁴/W[+] is a suppressor | partially of visible phenotype of mir-bft^unspecified/mir-bft^Δ263a

(Hilgers et al., 2010)

hid⁰⁵⁰¹⁴ is a suppressor of increased cell death phenotype of Rbf^15aΔ, gig⁶⁴

(Li et al., 2010)

hid⁰⁵⁰¹⁴ is a suppressor of increased cell death phenotype of Rbf^15aΔ, gig¹⁹²

(Li et al., 2010)

hid⁰⁵⁰¹⁴ is a suppressor of increased cell death | somatic clone phenotype of Rbf^15aΔ

(Tanaka-Matakatsu et al., 2009)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor | partially of increased cell death phenotype of Ras85D^KP

(Wu et al., 2009)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor | partially of visible phenotype of Ras85D^KP

(Wu et al., 2009)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 13 phenotype of Scer\GAL4^{VP16.nanos.UTR}, Tao^{UASp.Tag:FLAG}, nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 14 phenotype of Scer\GAL4^{VP16.nanos.UTR}, Tao^{UASp.Tag:FLAG}, nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 15 phenotype of Scer\GAL4^{VP16.nanos.UTR}, Tao^{UASp.Tag:FLAG}, nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 16 phenotype of Scer\GAL4^{VP16.nanos.UTR}, Tao^{UASp.Tag:FLAG}, nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 13 phenotype of Scer\GAL4^{VP16.nanos.UTR}, nanos^BN, skl^UASp.cSa

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 14 phenotype of Scer\GAL4^{VP16.nanos.UTR}, nanos^BN, skl^UASp.cSa

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 15 phenotype of Scer\GAL4^{VP16.nanos.UTR}, nanos^BN, skl^UASp.cSa

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 16 phenotype of Scer\GAL4^{VP16.nanos.UTR}, nanos^BN, skl^UASp.cSa

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 12 phenotype of nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 13 phenotype of nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of increased cell death | maternal effect | embryonic stage 14 phenotype of nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴ is a suppressor of increased cell death | embryonic stage phenotype of CycE^UAS.cLa, Scer\GAL4^en-e16E

(Parker, 2006)

NOT Suppressor of

Statement

Reference

hid⁰⁵⁰¹⁴/Df(3L)X14 is a non-suppressor of increased cell death | third instar larval stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^CCAP.PP

(Lee et al., 2019)

hid⁰⁵⁰¹⁴/Df(3L)X14 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^CCAP.PP

(Lee et al., 2019)

hid⁰⁵⁰¹⁴ is a non-suppressor of decreased cell death | third instar larval stage | conditional phenotype of Clbn^1Q

(Wang et al., 2013)

hid⁰⁵⁰¹⁴/hid[+] is a non-suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of ebi^1-334.GMR

(Lim et al., 2012)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a non-suppressor of visible phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

hid⁰⁵⁰¹⁴ has wing disc | third instar larval stage | conditional phenotype, non-enhanceable by Clbn^1Q/Clbn^1Q

(Wang et al., 2013)

hid⁰⁵⁰¹⁴ has eye disc phenotype, non-enhanceable by Rbf^120a

(Moon et al., 2008)

Suppressed by

Statement

Reference

hid⁰⁵⁰¹⁴/Df(3L)H99, Ras85D^KP has eye phenotype, suppressible by hep^NIG.4353R/Scer\GAL4^GMR.PF

(Wu et al., 2009)

NOT suppressed by

Statement

Reference

hid⁰⁵⁰¹⁴ has wing disc | third instar larval stage | conditional phenotype, non-suppressible by Clbn^1Q/Clbn^1Q

(Wang et al., 2013)

hid⁰⁵⁰¹⁴ has eye disc phenotype, non-suppressible by Rbf^120a

(Moon et al., 2008)

NOT Enhancer of

Statement

Reference

hid⁰⁵⁰¹⁴ is a non-enhancer of wing disc | third instar larval stage | conditional phenotype of Clbn^1Q

(Wang et al., 2013)

Suppressor of

Statement

Reference

hid⁰⁵⁰¹⁴/Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

hid⁰⁵⁰¹⁴/Scer\GAL4^GMR.PF is a suppressor of interommatidial bristle phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

hid⁰⁵⁰¹⁴/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, lin-52^GD12885

(Bhaskar et al., 2014)

hid⁰⁵⁰¹⁴ is a suppressor of eye disc | third instar larval stage phenotype of Clbn^UAS.cWa, Scer\GAL4^GMR.PU

(Wang et al., 2013)

hid⁰⁵⁰¹⁴/W[+] is a suppressor | partially of wing disc | posterior | third instar larval stage phenotype of E2f1^{PIP-3A-DBD.UASp.EGFP}, Scer\GAL4^en-e16E

(Davidson and Duronio, 2012)

hid⁰⁵⁰¹⁴ is a suppressor of wing disc phenotype of Scer\GAL4^ap-nd432, nab^EP-nd642

(Suissa et al., 2011)

hid⁰⁵⁰¹⁴/W[+] is a suppressor | partially of interommatidial bristle phenotype of mir-bft^unspecified/mir-bft^Δ263a

(Hilgers et al., 2010)

hid⁰⁵⁰¹⁴ is a suppressor of eye | somatic clone phenotype of Rbf^15aΔ

(Tanaka-Matakatsu et al., 2009)

hid⁰⁵⁰¹⁴ is a suppressor of eye disc | somatic clone | third instar larval stage phenotype of Rbf^15aΔ

(Tanaka-Matakatsu et al., 2009)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor | partially of eye phenotype of Ras85D^KP

(Wu et al., 2009)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 13 phenotype of Scer\GAL4^{VP16.nanos.UTR}, Tao^{UASp.Tag:FLAG}, nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 14 phenotype of Scer\GAL4^{VP16.nanos.UTR}, Tao^{UASp.Tag:FLAG}, nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 15 phenotype of Scer\GAL4^{VP16.nanos.UTR}, Tao^{UASp.Tag:FLAG}, nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 16 phenotype of Scer\GAL4^{VP16.nanos.UTR}, Tao^{UASp.Tag:FLAG}, nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 13 phenotype of Scer\GAL4^{VP16.nanos.UTR}, nanos^BN, skl^UASp.cSa

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 14 phenotype of Scer\GAL4^{VP16.nanos.UTR}, nanos^BN, skl^UASp.cSa

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 15 phenotype of Scer\GAL4^{VP16.nanos.UTR}, nanos^BN, skl^UASp.cSa

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 16 phenotype of Scer\GAL4^{VP16.nanos.UTR}, nanos^BN, skl^UASp.cSa

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 12 phenotype of nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 13 phenotype of nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a suppressor of primordial germ cell | maternal effect | embryonic stage 14 phenotype of nanos^BN

(Sato et al., 2007)

hid⁰⁵⁰¹⁴ is a suppressor of embryonic/larval salivary gland phenotype of sens^E2

(Chandrasekaran and Beckendorf, 2003)

hid⁰⁵⁰¹⁴/W[+] is a suppressor of embryonic epidermis phenotype of arm³

(Cox et al., 2000)

hid⁰⁵⁰¹⁴ is a suppressor of phenotype of arm⁴

(Cox et al., 2000)

NOT Suppressor of

Statement

Reference

hid⁰⁵⁰¹⁴/Df(3L)X14 is a non-suppressor of larval CCAP neuron | third instar larval stage phenotype of EcR^{B1-ΔC655.W650A.UAS}, Scer\GAL4^CCAP.PP

(Lee et al., 2019)

hid⁰⁵⁰¹⁴ is a non-suppressor of wing disc | third instar larval stage | conditional phenotype of Clbn^1Q

(Wang et al., 2013)

hid⁰⁵⁰¹⁴/hid[+] is a non-suppressor of retina | progressive phenotype of ebi^1-334.GMR

(Lim et al., 2012)

hid⁰⁵⁰¹⁴/Df(3L)H99 is a non-suppressor of eye phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

hid⁰⁵⁰¹⁴ is a non-suppressor of embryo | segment polarity expression pattern phenotype of wg^l-8

(Cox et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

hid⁰⁵⁰¹⁴ suppresses the severe irradiation-induced germline stem cell loss seen in Df(3L)ban^Δ1/+ mutants.

(Xing et al., 2015)

A hid⁰⁵⁰¹⁴ mutant background suppresses the eye phenotype seen upon expression of lin-52^GD12885 under the control of Scer\GAL4^GMR.PF, along with a dramatic reduction in apoptosis in the eye-antennal disc.

(Bhaskar et al., 2014)

hid⁰⁵⁰¹⁴ Clbn^1Q/Clbn^1Q double mutants show similar apoptosis induction in wing discs in response to irradiation as either mutant alone. hid⁰⁵⁰¹⁴ suppresses the induction of apoptosis seen in third instar eye discs with expression of Clbn^Scer\UAS.cWa driven by Scer\GAL4^GMR.PU.

(Wang et al., 2013)

One copy of W⁰⁵⁰¹⁴ partially suppresses the apoptosis seen in the posterior compartment of third instar larval wing discs expressing E2f^{PIP-3A-DBD.Scer\UAS.P\T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^en-e16E.

One copy of W⁰⁵⁰¹⁴ partially suppresses the apoptosis seen in the posterior compartment of third instar larval wing discs expressing E2f^{PIP-3A.Scer\UAS.P\T.T:Avic\GFP-EGFP} under the control of Scer\GAL4^en-e16E.

(Davidson and Duronio, 2012)

hid⁰⁵⁰¹⁴/+ does not suppress the late-onset retinal degeneration phenotype of ebi^1-334.GMR/+ flies.

(Lim et al., 2012)

Removal of one copy of W through a W⁰⁵⁰¹⁴ heterozygous background significantly attenuates nab^EP642-induced apoptosis in the dorsal compartment of the wing imaginal disc (using the Scer\GAL4^ap.nd432 driver).

(Suissa et al., 2011)

W⁰⁵⁰¹⁴/+ partially suppresses the loss of interommatidial bristles which is seen in bft^Δ263a/bft^unspecified flies.

(Hilgers et al., 2010)

The presence of a W⁰⁵⁰¹⁴ background significantly decreases gig¹⁹²/Rbf^15aΔ induced cell death. Some cell death is still observed, particularly in the anterior of the eye disc.

The presence of a W⁰⁵⁰¹⁴ background significantly decreases gig⁶⁴/Rbf^15aΔ induced cell death. Some cell death is still observed, particularly in the anterior of the eye disc.

(Li et al., 2010)

Rbf^15aΔ; W⁰⁵⁰¹⁴ double mutant clones occupy a dramatically increased area of the eye compared to Rbf^15aΔ single mutant clones. The morphology of the eye is relatively normal with occasional extra interommatidial bristles. No cell death or nuclear pyknosis is observed in eye disc clones.

(Tanaka-Matakatsu et al., 2009)

Df(3L)H99/W⁰⁵⁰¹⁴ partially suppresses the cell death phenotype of Ras85D^KP mutant flies.

Expression of hep^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^GMR.PF) in flies carrying Df(3L)H99/W⁰⁵⁰¹⁴ in a Ras85D^KP mutant background strongly suppresses the eye phenotype.

(Wu et al., 2009)

A W⁰⁵⁰¹⁴ heterozygous background suppresses lethality found in Df(3L)ban^Δ1 mutants to generate wild-type levels of survival when larvae are irradiated with 0-8000 R of X-rays.

(Jaklevic et al., 2008)

Similarly to W⁰⁵⁰¹⁴ single mutants, DNA-damage induced apoptosis is completely abolished in Rbf^120a, W⁰⁵⁰¹⁴ double mutant eye discs.

(Moon et al., 2008)

Removal of zygotic W (W⁰⁵⁰¹⁴/Df(3L)H99) suppresses the pole cell apoptosis seen in embryos derived from nos^BN females. Approximately 7% of pole cells examined at stage 12-14 are undergoing apoptosis.

Removal of zygotic W (W⁰⁵⁰¹⁴/Df(3L)H99) suppresses the pole cell apoptosis seen when Tao-1^{Scer\UAS.P\T.T:Zzzz\FLAG} is expressed under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in stage 13-16 embryos derived from nos^BN females.

Removal of zygotic W (W⁰⁵⁰¹⁴/Df(3L)H99) suppresses the pole cell apoptosis seen when skl^{Scer\UAS.P\T.cSa} is expressed under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in stage 13-16 embryos derived from nos^BN females.

(Sato et al., 2007)

Expressing CycE^Scer\UAS.cLa under the control of Scer\GAL4^en-e16E in W⁰⁵⁰¹⁴ embryos reduces the level of apoptosis in embryonic posterior compartment cells by 65% compared to when CycE^Scer\UAS.cLa is expressed in a wild-type background.

(Parker, 2006)

There is no increase in the survival of neuroblasts in the abdominal neuromeres in W⁰⁵⁰¹⁴/Df(3L)H99 larvae compared to wild type.

(Peterson et al., 2002)

Addition of W⁰⁵⁰¹⁴ or Df(3L)H99 does not result in any pronounced improvement of the wg^l-8 segment polarity defect; all cells still secrete a uniform lawn of denticles and the cuticle remains smaller than wild type in double mutant embryos.

(Cox et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

83349

P{PZ}hid⁰⁵⁰¹⁴/TM6B, Tb⁺

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: Eip75B⁰⁰²²⁵. Complements: l(3)00714⁰⁰⁷¹⁴. Complements: not⁰²⁰⁶⁹. Complements: Eip75B⁰³²⁴⁷. Complements: not⁰⁶⁸⁰⁶. Complements: l(3)j13B3^j13B3. Complements: not^j4B8a. Complements: not^j9A6. Complements: l(3)neo26¹.

(BDGP Project Members, 1994-1999)

Precise excision of the P{PZ} insertion demonstrates the P-element insertion is responsible for the mutant phenotype.

(Grether et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

05014

(Tanaka-Matakatsu et al., 2007)

Hid⁰⁵⁰¹⁴

(Wu et al., 2009)

W⁰⁵⁰¹⁴

(Tanaka-Matakatsu et al., 2009, Wang et al., 2008)

hid⁰⁵⁰¹⁴

hid^P05014

(Lee et al., 2019, Wells et al., 2006, Moon et al., 2005)

hid^P

(Lee et al., 2019, Lin et al., 2004)

hid<up>PZ 05014</up>

(Tanaka-Matakatsu et al., 2009)

hid^l(3)05014

(Xing et al., 2015, Jaklevic et al., 2008)

l(3)05014

(Cordero et al., 2004, Jassim et al., 2003, Spradling et al., 1999)

l(3)05014⁰⁵⁰¹⁴

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Secondary FlyBase IDs

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