FlyBase Allele Report: Dmel\Ten-m[05309]

General Information

Symbol

Dmel\Ten-m⁰⁵³⁰⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0009535

Feature type

allele

Associated gene

Dmel\Ten-m

Associated Insertion(s)

P{PZ}Ten-m⁰⁵³⁰⁹

Carried in Construct

Also Known As

odz^l(3)5309, l(3)05309, Penh22

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Baumgartner et al., 1994)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

Insertion at nucleotide 4191, 30bp from the beginning of transcription.

(Levine et al., 1997)

Insertion in 5' non-coding region of the transcript.

(Levine et al., 1994)

Insertion components

P{PZ}Ten-m⁰⁵³⁰⁹

Product class / Tool use(s)

Encoded product / tool

Tagged with

nuclear protein localization tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Zheng et al., 2011)

abnormal neuroanatomy | embryonic stage (with Ten-m^CB04632)

(Zheng et al., 2011)

lethal (with Df(3L)Exel6138)

(Zheng et al., 2011)

lethal (with Df(3L)Ten-m-AL1)

(Zheng et al., 2011)

lethal (with Df(3L)Ten-m-AL29)

(Zheng et al., 2011)

lethal (with Ten-m⁶²⁸)

(Zheng et al., 2011)

lethal (with Ten-m^CB04632)

(Zheng et al., 2011)

lethal (with Ten-m^KG00101)

(Zheng et al., 2011)

lethal (with Ten-m^Δ510)

(Zheng et al., 2011)

lethal (with Ten-m^Δ525)

(Zheng et al., 2011)

lethal | recessive

(Zheng et al., 2011, Spradling et al., 1999)

viable (with Ten-m^N1-R11)

(Zheng et al., 2011)

viable (with Ten-m^N1-R60)

(Zheng et al., 2011)

Phenotype Manifest In

intersegmental nerve | embryonic stage

(Zheng et al., 2011)

intersegmental nerve | embryonic stage (with Ten-m^CB04632)

(Zheng et al., 2011)

Detailed Description

Statement

Reference

Homozygous and Ten-m^CB04632/Ten-m⁰⁵³⁰⁹ embryos show defects in the guidance of the intersegmental nerve in the periphery.

(Zheng et al., 2011)

Mutant larvae do not have defects in the establishment or maintenance of dendritic tiling in class IV dendrite arborisation (da) neurons.

(Parrish et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Ten-m[+]/Ten-m⁰⁵³⁰⁹ is an enhancer of ommatidium phenotype of hh^bar3

(Levine et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Ten-m⁰⁵³⁰⁹/+ enhances the loss of ommatidia phenotype which is seen in hh^bar3 homozygotes.

(Levine et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Ten-m^rJ307

(BDGP Project Members, 1994-1999)

Fails to complement

Ten-m⁰⁰⁸⁴⁴

(BDGP Project Members, 1994-1999)

Ten-m⁰⁰⁸⁷⁶

(BDGP Project Members, 1994-1999)

Ten-m⁰²⁰¹⁷

(BDGP Project Members, 1994-1999)

Ten-m^rP126

(BDGP Project Members, 1994-1999)

Ten-m⁰²²¹⁸

(BDGP Project Members, 1994-1999)

Ten-m^rL201

(BDGP Project Members, 1994-1999)

Rescued by

Ten-m⁰⁵³⁰⁹ is rescued by Ten-m^+t133

(Zheng et al., 2011)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11657

P{PZ}TAF1C-like^05309b; P{PZ}Ten-m⁰⁵³⁰⁹ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Separable from: CG10496^05309b. Evidence suggests that the "l(3)05309" line contains 2 P{PZ} insertions; one at 57E (P{PZ}CG10496^05309b) corresponding to the site of the flanking sequence AQ073328, and one at 79E (P{PZ}Ten-m⁰⁵³⁰⁹) which causes a mutation in Ten-m.

(FlyBase, 1996-)

The segmentation defects previously reported to be due to the Ten-m⁰⁵³⁰⁹ mutation are not due to the Ten-m⁰⁵³⁰⁹ mutation, but instead are caused by a mutation in the opa gene (represented in by the opa^rSS allele) present on the TM3-rSS balancer in the original stock.

(Zheng et al., 2011)

Comments

Complements: l(3)00506⁰⁰⁵⁰⁶. Complements: Aats-ile⁰⁰⁸²⁷. Complements: Hem⁰³³³⁵. Complements: Csp⁰³⁹⁸⁸. Complements: l(3)04053⁰⁴⁰⁵³. Complements: l(3)09070⁰⁹⁰⁷⁰. Complements: l(3)04053^j8B2. Complements: TyrR^neo30.

(BDGP Project Members, 1994-1999)

FlyBase curator comment: FBrf0214744 characterises new loss of function mutations in Ten-m and finds no evidence of a pair-rule segmentation phenotype, in contrast to previous reports. The authors show that the pair-rule phenotype previously reported for a number of Ten-m mutations (including Ten-m⁰⁵³⁰⁹) was in fact due to a mutation present on the balancer in the original stock. The segmentation phenotype described in FBrf0075161, FBrf0073721, FBrf0098973 and FBrf0204395 for Ten-m⁰⁵³⁰⁹ has thus been removed from the allele report in FlyBase, since it is not due to the mutation in Ten-m.

(FlyBase, 1992-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

5309

(Zheng et al., 2011)

Penh22

(Levine et al., 1997, Levine et al., 1994)

Ten-m⁰⁵³⁰⁹

(Zheng et al., 2011, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Parrish et al., 2007, Venken, 2006)

Ten-m⁵³⁰⁹

(Zhang et al., 2018)

Ten-m^l(3)5309

(Zheng et al., 2011)

l(3)05309

(Spradling et al., 1999, Baumgartner et al., 1994)

l(3)05309⁰⁵³⁰⁹

l(3)5309

(Rakovitsky et al., 2007)

odz⁵³⁰⁹

(Rakovitsky et al., 2007)

odz^l(3)5309

(Kinel-Tahan et al., 2007, Rakovitsky et al., 2007, Levine et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

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