Allele Dmel\Ten-m⁰⁵³⁰⁹

General Information
Symbol	Dmel\Ten-m⁰⁵³⁰⁹	Species	D. melanogaster
Name		FlyBase ID	FBal0009535
Feature type	allele	Associated gene	Dmel\Ten-m
Also Known As	odz^l(3)5309, l(3)05309, Penh22

Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (Baumgartner et al., 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion at nucleotide 4191, 30bp from the beginning of transcription. (Levine et al., 1997) Insertion in 5' non-coding region of the transcript. (Levine et al., 1994)
Caused by insertion	P{PZ}Ten-m⁰⁵³⁰⁹ (BDGP Project Members, 1994-1999, Spradling et al., 1999, Braun et al., 1997, FlyBase, 1996-, Venken, 2006, Baumgartner et al., 1994, Levine et al., 1994, Levine et al., 1997, Zheng et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (with Df(3L)Exel6138) (Zheng et al., 2011) lethal (with Df(3L)Ten-m-AL1) (Zheng et al., 2011) lethal (with Df(3L)Ten-m-AL29) (Zheng et al., 2011) lethal (with Ten-m⁶²⁸) (Zheng et al., 2011) lethal (with Ten-m^CB04632) (Zheng et al., 2011) lethal (with Ten-m^KG00101) (Zheng et al., 2011) lethal (with Ten-m^Δ510) (Zheng et al., 2011) lethal (with Ten-m^Δ525) (Zheng et al., 2011) lethal \| recessive (Spradling et al., 1999, Zheng et al., 2011) neuroanatomy defective \| embryonic stage (Zheng et al., 2011) neuroanatomy defective \| embryonic stage (with Ten-m^CB04632) (Zheng et al., 2011) viable (with Ten-m^N1-R11) (Zheng et al., 2011) viable (with Ten-m^N1-R60) (Zheng et al., 2011)
Phenotype Manifest In
	intersegmental nerve \| embryonic stage (Zheng et al., 2011) intersegmental nerve \| embryonic stage (with Ten-m^CB04632) (Zheng et al., 2011)
Detailed Description
	Statement Reference Homozygous and Ten-m[CB04632]/Ten-m[05309] embryos show defects in the guidance of the intersegmental nerve in the periphery. (Zheng et al., 2011) Mutant larvae do not have defects in the establishment or maintenance of dendritic tiling in class IV dendrite arborisation (da) neurons. (Parrish et al., 2007)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement Reference Ten-m[+]/Ten-m⁰⁵³⁰⁹ is an enhancer of ommatidium phenotype of hh^bar3 (Levine et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference Ten-m[05309]/+ enhances the loss of ommatidia phenotype which is seen in hh[bar3] homozygotes. (Levine et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	Ten-m^rJ307 (BDGP Project Members, 1994-1999)
Fails to complement	Ten-m⁰⁰⁸⁴⁴ (BDGP Project Members, 1994-1999) Ten-m⁰⁰⁸⁷⁶ (BDGP Project Members, 1994-1999) Ten-m⁰²⁰¹⁷ (BDGP Project Members, 1994-1999) Ten-m⁰²²¹⁸ (BDGP Project Members, 1994-1999) Ten-m^rL201 (BDGP Project Members, 1994-1999) Ten-m^rP126 (BDGP Project Members, 1994-1999)
Rescued by	Ten-m⁰⁵³⁰⁹ is rescued by Ten-m^+t133 (Zheng et al., 2011)
Comments
Stocks ( 1 )
Bloomington	11657 P{PZ}CG10496^05309b; P{PZ}Ten-m⁰⁵³⁰⁹ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹
Notes on Origin
Discoverer	A. Spradling.
	The segmentation defects previously reported to be due to the Ten-m[05309] mutation are not due to the Ten-m[05309] mutation, but instead are caused by a mutation in the opa gene (represented in by the opa[rSS] allele) present on the TM3-rSS balancer in the original stock. (Zheng et al., 2011) Separable from: CG10496^05309b. Evidence suggests that the "l(3)05309" line contains 2 P{PZ} insertions; one at 57E (P{PZ}CG10496^05309b) corresponding to the site of the flanking sequence AQ073328, and one at 79E (P{PZ}Ten-m⁰⁵³⁰⁹) which causes a mutation in Ten-m. (FlyBase, 1996-)
Comments
	Complements: l(3)00506⁰⁰⁵⁰⁶. Complements: Aats-ile⁰⁰⁸²⁷. Complements: Hem⁰³³³⁵. Complements: Csp⁰³⁹⁸⁸. Complements: l(3)04053⁰⁴⁰⁵³. Complements: l(3)09070⁰⁹⁰⁷⁰. Complements: l(3)04053^j8B2. Complements: TyrR^neo30. (BDGP Project Members, 1994-1999) FlyBase curator comment: FBrf0214744 characterises new loss of function mutations in Ten-m and finds no evidence of a pair-rule segmentation phenotype, in contrast to previous reports. The authors show that the pair-rule phenotype previously reported for a number of Ten-m mutations (including Ten-m[05309]) was in fact due to a mutation present on the balancer in the original stock. The segmentation phenotype described in FBrf0075161, FBrf0073721, FBrf0098973 and FBrf0204395 for Ten-m[05309] has thus been removed from the allele report in FlyBase, since it is not due to the mutation in Ten-m. (FlyBase, 1992-)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	5309 (Zheng et al., 2011) l(3)05309 (Spradling et al., 1999, Baumgartner et al., 1994) l(3)5309 (Rakovitsky et al., 2007) l(3)05309⁰⁵³⁰⁹ odz⁵³⁰⁹ (Rakovitsky et al., 2007) odz^l(3)5309 (Rakovitsky et al., 2007, Levine et al., 1997, Kinel-Tahan et al., 2007) Penh22 (Levine et al., 1994, Levine et al., 1997) Ten-m⁰⁵³⁰⁹ (Venken, 2006, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Zheng et al., 2011, Parrish et al., 2007) Ten-m^l(3)5309 (Zheng et al., 2011) unnamed (Braun et al., 1997)
Name Synonym
Secondary FlyBase IDs

References ( 18 )
Research paper	Zheng et al., 2011, PLoS ONE 6(8): e22956 Drosophila Ten-m and Filamin Affect Motor Neuron Growth Cone Guidance. [FBrf0214744] Kinel-Tahan et al., 2007, Dev. Dyn. 236(9): 2541--2554 Drosophila odz gene is required for multiple cell types in the compound retina. [FBrf0201077] Parrish et al., 2007, Genes Dev. 21(8): 956--972 Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. [FBrf0201136] Rakovitsky et al., 2007, Mech. Dev. 124(11-12): 911--924 Drosophila Ten-a is a maternal pair-rule and patterning gene. [FBrf0204395] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Braun et al., 1997, Genetics 147(2): 623--634 Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap. [FBrf0098749] Levine et al., 1997, Gene 200(1-2): 59--74 The genetics and molecular structure of the Drosophila pair-rule gene odd Oz (odz). [FBrf0098973] Levine et al., 1997, Dev. Dyn. 209(1): 1--14 Expression of the pair-rule gene odd Oz (odz) in imaginal tissues. [FBrf0095569] Baumgartner et al., 1994, EMBO J. 13(16): 3728--3740 ten^m, a Drosophila gene related to tenascin, is a new pair-rule gene. [FBrf0075161] Levine et al., 1994, Cell 77(4): 587--598 Odd Oz: a novel Drosophila pair rule gene. [FBrf0073721]
Supplementary material	Venken, 2006, Science 314(5806): Supporting Online Material. [FBrf0199318]
Personal communication to FlyBase	Christensen et al., 2008.4.15, Isolation and characterization of Df(3L)BSC451. Isolation and characterization of Df(3L)BSC451. [FBrf0204486] Christensen et al., 2008.4.15, Isolation and characterization of Df(3L)BSC420. Isolation and characterization of Df(3L)BSC420. [FBrf0204556] Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Allele Dmel\Ten-m05309

Allele Dmel\Ten-m⁰⁵³⁰⁹