FlyBase Allele Report: Dmel\Tecr[05634]

General Information

Symbol

Dmel\Tecr⁰⁵⁶³⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0009544

Feature type

allele

Associated gene

Dmel\Tecr

Associated Insertion(s)

P{PZ}Tecr⁰⁵⁶³⁴

Carried in Construct

Also Known As

l(3)05634, Sc2⁰⁵⁶³⁴

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}Tecr⁰⁵⁶³⁴

Cytology

Description

P{PZ} insertion is 1913bp upstream of the putative ATG start codon.

(Fernandez-Funez et al., 2000)

P{PZ} insertion in Sc2, 98bp downstream of the putative AUG initiation codon.

(Vaskova et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:3,903,639..3,903,639 [+]

(Branco et al., 2008, Fernandez-Funez et al., 2000, Vaskova et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^30Q.UAS

(Fernandez-Funez et al., 2000)

modeled by Hsap\ATXN1^82Q.UAS

(Fernandez-Funez et al., 2000)

exacerbates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Branco et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Vaskova et al., 2000, Spradling et al., 1999)

lethal - all die before end of larval stage

(Chen et al., 2010)

lethal - all die before end of larval stage (with Df(3L)GN19)

(Vaskova et al., 2000)

some die during larval stage

(Chen et al., 2010)

some die during larval stage (with Df(3L)GN19)

(Vaskova et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Sc2⁰⁵⁶³⁴ under the control of Scer\GAL4^GMR.PF does not result in a rough eye phenotype.

(Shulman and Feany, 2003)

Hemizygotes complete embryogenesis and hatch on schedule, but they die as first or second instar larvae.

(Vaskova et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Tecr⁰⁵⁶³⁴ is a non-enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Tecr^EY02236/Tecr⁰⁵⁶³⁴ is a suppressor of abnormal cytokinesis phenotype of Pex13^KG04339

(Chen et al., 2010)

Tecr⁰⁵⁶³⁴ is a suppressor of visible | dominant phenotype of Kr^If-1

(Abrell et al., 2000)

Sc2[+]/Tecr⁰⁵⁶³⁴ is a suppressor of visible | dominant phenotype of Kr^If-1

(Carrera et al., 1998)

NOT Suppressor of

Statement

Reference

Tecr⁰⁵⁶³⁴ is a non-suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sc2[+]/Tecr⁰⁵⁶³⁴ is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Tecr⁰⁵⁶³⁴ is an enhancer of eye phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

Tecr⁰⁵⁶³⁴ is an enhancer of retina phenotype of Hsap\ATXN1^82Q.UAS, Scer\GAL4^GMR.PF

(Fernandez-Funez et al., 2000)

NOT Enhancer of

Statement

Reference

Sc2[+]/Tecr⁰⁵⁶³⁴ is a non-enhancer of retina phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

(Branco et al., 2008)

Tecr⁰⁵⁶³⁴ is a non-enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Tecr⁰⁵⁶³⁴ is a suppressor of eye phenotype of Kr^If-1

(Abrell et al., 2000)

Tecr⁰⁵⁶³⁴ is a suppressor of ommatidium phenotype of Kr^If-1

(Abrell et al., 2000)

Sc2[+]/Tecr⁰⁵⁶³⁴ is a suppressor of eye phenotype of Kr^If-1

(Carrera et al., 1998)

NOT Suppressor of

Statement

Reference

Tecr⁰⁵⁶³⁴ is a non-suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Sc2⁰⁵⁶³⁴/Sc2^EY02236 transheterozygotes partially suppress the pex13^KG04339 cytokinesis defect.

(Chen et al., 2010)

Xenogenetic Interactions

Statement

Reference

One copy of Sc2⁰⁵⁶³⁴ does not enhance the retinal phenotype seen when Hsap\HTT^{128Q.1-336.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Sc2⁰⁵⁶³⁴ enhances the retinal phenotype seen when Hsap\ATXN1^82Q.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PU.

(Branco et al., 2008)

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is not modified if the flies are also carrying Sc2⁰⁵⁶³⁴.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Fails to complement

Tecr^E15

(Vaskova et al., 2000)

Tecr^A4

(Vaskova et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11666

P{PZ}Tecr⁰⁵⁶³⁴ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Sc2⁰⁵⁶³⁴

(Chen et al., 2010, Branco et al., 2008)

Tecr⁰⁵⁶³⁴

Ubi-p63E⁰⁵⁶³⁴

l(3)05634

(Shulman and Feany, 2003, Abrell et al., 2000, Vaskova et al., 2000, Spradling et al., 1999, Carrera et al., 1998)

l(3)05634⁰⁵⁶³⁴

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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