FlyBase Allele Report: Dmel\Stat92E[06346]

Wild type eyes containing Stat92E⁰⁶³⁴⁶ mutant clones are normal in size. Eyes containing Stat92E⁰⁶³⁴⁶ mutant clones in a Minute background are small compared with Minute controls. Elimination of cells adjacent to Stat92E⁰⁶³⁴⁶ mutant clones (using hid) also results in reduced eye size.

(Wu et al., 2010)

40% of embryos from Stat92E⁰⁶³⁴⁶ germ line clones show germ-band extension defects.

(Bertet et al., 2009)

Stat92E⁰⁶³⁴⁶ homozygous embryos have mild patterning defects, in which somatic muscles generally appear thinner than normal.

Embryos derived from Stat92E⁰⁶³⁴⁶ germ-line clones, and which also express Stat92E^Scer\UAS.cSa via Scer\GAL4^en.PU (to rescue segmentation defects), have extensive defects in somatic muscle development, especially in lateral and dorsal regions of the embryo where many muscles are missing and myoblasts remain unfused. These phenotypes are even more severe where embryos are additionally zygotically mutant for Stat92E⁰⁶³⁴⁶ - a large percentage of somatic muscles are absent and the remaining muscles have no clear identity or shape. These somatic muscle defects show complete penetrance and affect all segments of the embryo. Visceral muscle develops relatively normally.

(Liu et al., 2009)

Very few Stat92E⁰⁶³⁴⁶ mutant cyst progenitor cell clones are recovered compared to controls.

(Leatherman and DiNardo, 2008)

Adults with Stat92E⁰⁶³⁴⁶ clones in a Minute background have aberrantly small eyes.

(Ekas et al., 2006)

When Stat92E⁰⁶³⁴⁶/Stat92E^F females are shifted to the non-permissive temperature (30^oC), the number of gemline stem cells per ovariole falls from 2, to an average of 1.3 per per ovariole at day 2 and to just 0.6 per ovariole at day 6. By this time only 9% of ovarioles contain 2, and in these cases they are no longer associated with cap cells, and 48% contain none. Within a few days of shifting to 30^oC, escort stem cells and escort cells lose their wild-type, extended shape and form an epithlial monolayer around the remaining aggregated germ cells. Shifting these animals to the permissive temperature also has dramatic effects on ovariole shape: the space between the basement membrane and the sheath muscle swells dramatically, filling with amorphous material and making the ovariole shrink in diameter. Some sheath associated cells undergo extra endocycles to form giant polyploid nuclei.

(Decotto and Spradling, 2005)

Border cell migration is inhibited in Stat92E⁰⁶³⁴⁶/Stat92E^F following maintenance of egg chambers at the restrictive temperature. The severity of the phenotype increases with time spent at the restrictive temperature, with over 90% of egg chambers affected following 4 hours at 29^oC. However, border cell number is not reduced.

(Silver et al., 2005)

The proliferation of germ cells in male Stat92E⁰⁶³⁴⁶ embryos is reduced compared to controls.

(Wawersik et al., 2005)

At 18^oc, Stat92E^F/Stat92E⁰⁶³⁴⁶ male adults have wild-type testes. After a 1 day shift to 29^oC, one to three clusters of germ cells with branching fusomes contact the hub in 95% of Stat92E^F/Stat92E⁰⁶³⁴⁶ testes (in wild-type males, only germline stem cells (GSCs) with round fusomes contact the hub). In addition there is an increased number of two- and four-cell cysts in the mutant testes, indicating that multiple GSCs have differentiated. As the length of time at 29^oC is increased, GSCs, then spermatogonia and finally spermatocytes are lost in the mutant testes. Dying GSCs are not detected in Stat92E^F/Stat92E⁰⁶³⁴⁶ testes at 29^oC and a similar number of dying spermatogonial cysts are detected in both mutant and control testes at 29^oC, indicating that differentiation and not cell death accounts for the progressive loss of GSCs and their progeny within the mutant testes at 29^oC. The number of somatic cells (excluding hub cells) in the Stat92E^F/Stat92E⁰⁶³⁴⁶ testes declines progressively at 29^oC. When Stat92E^F/Stat92E⁰⁶³⁴⁶ male adults shifted to 29^oC for 1 day are returned to 18^oC for 4 days, the number of germline stem cells (GSCs) increases significantly. After 2 days at 29^oC, only 22.5% of Stat92E^F/Stat92E⁰⁶³⁴⁶ testes still contain GSCs, but after a brief recovery at 18^oC (2 days), the number of mutant testes containing GSCs increases to 75,8%, indicating that testes which had completely lacked GSCs have regained them. These testes are different from wild type; although GSCs surround the hub, they contact spermatocytes, because the intermediate spermatogonial cells are missing. After a longer recovery period at 18^oC, a normal zone of spermatogonial cysts is regained in the mutant testes, indicating that the regenerated GSCs are functional. Somatic stem cells also return in testes undergoing repopulation with GSCs. Stat92E^F/Stat92E⁰⁶³⁴⁶ males that have been shifted to 29^oC for 6 days (which lack spermatogonia but contain spermatocytes) never regain lost GSCs when returned to 18^oC, suggesting that the regained GSCs are derived from spermatogonia that have reverted to stem cell fate. This is confirmed by labelling of spermatogonial cysts in Stat92E^F/Stat92E⁰⁶³⁴⁶ males which have been shifted to 29^oC for 4 days (the testes of these males lack GSCs but contain spermatogonia); labelled spermatogonial cysts are detected near the hub in 6% of testes before recovery, and after a recovery of 2 days at 18^oC, 6% of testes regain labelled GSCs (which are only detected near the hub). In addition, the level of labeling in each GSC indicates that each spermatogonial cyst breaks apart and regenerates multiple single GSCs during recovery at 18^oC.

(Brawley and Matunis, 2004)

The proventriculus development is normal in early stages of proventriculus development in mutants. However in the keyhole stage, the anterior boundary cells fail to move inward into the endodermal keyhole domain and arrest anterior to the proventricular endoderm until late stages of embryonic development. Furthermore, the endodermal cell layer of the keyhole is disorganised and the proventriculus is collapsed.

(Josten et al., 2004)

Paternally rescued Stat92E⁰⁶³⁴⁶ germ-line clone embryos are missing denticle belt A5 and part of A4. In the absence of paternal rescue, more severe segmentation defects are seen.

(Chen et al., 2003)

Homozygous embryos derived from homozygous female germline clones (lacking both maternal and zygotic Stat92E function) have incompletely elongated hindguts which are wider than normal. There are a greater number of cells in the circumference of the mutant hindgut than in wild type. The total number of hindgut epithelial cells is 85% of wild type.

(Johansen et al., 2003)

Embryos derived from homozygous Stat92E⁰⁶³⁴⁶ female germ line clones have 20-30% fewer pole cells by the cellularization stage, due to mitotic defects, when compared with wild-type cells. At stage 11, the pole cells in these mutants are still associated with the gut, while those in wild-type embryos of the same stage have already become associated with the dorsal mesoderm. Embryos derived from homozygous Stat92E⁰⁶³⁴⁶ female germ line clones that have also inherited Stat92E⁰⁶³⁴⁶ from their father are unable to form gonads, and contain randomly scattered pole cells in the cavity of the embryo. Mutant embryos that have inherited wild-type Stat92E from their father have a less severe phenotype; the majority lack one gonad and have more pole cells in the remaining gonad when compared to wild-type embryos. Mosaic flies can be recovered following the transplantation of pole cells from Stat92E⁰⁶³⁴⁶ female germ line clones and wild-type fathers into wild-type embryos. Such mosaic flies are never recovered when the transplanted pole cells are derived from a Stat92E⁰⁶³⁴⁶ father as well as a Stat92E⁰⁶³⁴⁶ germ line clone mother. These transplanted pole cells migrate to ectopic locations instead of migrating toward the somatic gonad of the transplanted embryo.

(Li et al., 2003)

In zygotic null embryos, the tracheal pits form later and remain smaller than in wild-type siblings. IN late stages they exhibit severe defects in the tracheal branches. In embryos lacking both zygotic and maternal contributions all the tracheal pits are missing and little or no tracheae are found in later stage embryos. The hindgut of maternally and zygotically null (Stat92E⁰⁶³⁴⁶) embryos are shorter and have fewer cells than those of wild-type. The hindgut nuclei are staggered into double layers in the gut epithelium, making it thicker than wild-type. The central nervous system (CNS) of maternally and zygotically null (Stat92E⁰⁶³⁴⁶) embryos is grossly disrupted and in some segments of the CNS are completely missing. Similar but milder defects are seen in animals lacking only the maternal contribution, these defects include gaps in the longitudinal tracts and missing commissures. Often neurons that remained (e.g pCC and aCC) failed to grow axons. Similar defects in the peripheral nervous system are seen. Many PNS neurons fail to extend their axons in maternal mutants, and maternal and zygotic mutants many neurons are absent.

(Li et al., 2003)

Follicle cell clones of Stat92E⁰⁶³⁴⁶ cause a cell-autonomous loss-of-stalk fate.

(Torres et al., 2003)

Stat92E^F/Stat92E⁰⁶³⁴⁶ mutants show a temperature sensistive reduction in female fecundity. At 20^oC females lay on average 50-60 eggs, most of them unfertilized. Approximately 10% develop into adults. At 25^oC young females lay only a few eggs which are small and have abnormal dorsal appendages. When cultured at 25^oC then shifted to 29^oC as early pupae Stat92E^F/Stat92E⁰⁶³⁴⁶ mutant females produce no eggs. Dissected ovaries of the mutants grown at these temperatures show abnormalities in the ovaries including fused egg chambers and the lack of interfollicle cells. The severity of the phenotype increases with age of the females and increasing temperature. A considerable amount of cell death is seen in the ovarioles of older females. More severe defects are seen in females shifted to 29^oC during the pupal stage; oogenesis is arrested at or before stage 4 and no egg chambers are pinched off from the germarium. Stat92E^F/Stat92E⁰⁶³⁴⁶ adults have a number of defects including tissue protruding from the adult humeral cuticle, abnormal anterior spiracles, ectopic wing veins, additional spermatheca and adult leg defects. Mosaic ovarioles in which the follicle cells are homozygous for Stat92E⁰⁶³⁴⁶ are often fused and degenerating. Mosaic ovarioles which have primarily mutant follicle cells, but wild type follicle cells at the termini are phenotypically wild type.

(Baksa et al., 2002)

When homozygous mutant clones are made in the ovary, mutant border cells are found at the anterior tip, or displaced along the side of the egg chamber. Displacement of the border cell cluster is only observed when flanking stretch cells are mutant as well. Clones of mutant stretch cells are sometimes thicker than normal. Mutant centripetal cells appear normal in morphology and movement.

(Beccari et al., 2002)

Paternally rescued embryos derived from females containing homozygous germ-line clones lack abdominal segment 5 and part of abdominal segment 4. These embryos form a defective tracheal system with several disruptions in the main trunk and many branches.

(Chen et al., 2002)

Embryos derived from homozygous female germline clones show deletion of segment A5.

(Li et al., 2002)

Homozygous embryos have a mild spiracle phenotype with slightly thinner filzkorper than normal. Homozygous embryos have segmentation defects. The trachea are mostly absent in homozygous embryos derived from homozygous female germline clones. The trachea form in paternally rescued embryos derived from homozygous female germline clones (which still have segmentation defects).

(Brown et al., 2001)

Homozygous clones are generated in the germ line of the testis at the same frequency as in wild-type controls, but homozygous germ line stem cells do not establish persistent clones; although clusters of differentiating mutant spermatocytes are seen, no early-stage homozygous germ cells are evident in testes containing clones 7 days after clone induction.

(Kiger et al., 2001)

When homozygous somatic clones are made in the egg chamber, defects in border cell migration are seen. Border cell clusters in which the polar cells are wild-type, but the outer border cells are mutant, exhibit migration failure. Large mutant clones in the remaining follicle epithelium do not produce border cell migration failure. In mutant egg chambers outer border cell clusters consist of an average of 2.2 cells, as compared to 6 in wild-type.

(Silver and Montell, 2001)

Homozygous germ line stem cells are frequently detected in the testis two days after clone induction. However, the percentage of testes containing germ line stem cell clones decreases over time and they are absent by 9 days after clone induction.

(Tulina and Matunis, 2001)

Somatic clones in the eye show no detectable defects.

(Luo et al., 1999)

Stat92E⁰⁶³⁴⁶ embryos derived from homozygous female germ line clones show loss of the fifth abdominal denticle band and the posterior mid-ventral portion of the fourth band. Variable reduction of the second thoracic and eighth abdominal denticle bands and variable fusion of the sixth and seventh denticle bands is seen.

(Harrison et al., 1998)

Embryos exhibit segmentation defects. Homozygotes die at the end of embryogenesis or as young larvae.

(Luo et al., 1997)

Maternal effect segmentation phenotype is similar to that caused by loss of hop activity during embryogenesis. Both paternally rescued and unrescued embryos show a consistent deletion of the fifth abdominal segment and the posterior midventral portion of the fourth abdominal segment. Additional defects are seen in the head and tail of the unrescued embryos. Homozygous dead larvae have a normal cuticle pattern, but larval diploid imaginal tissues are reduced in size.

(Hou et al., 1996)

Germline clones produce eggs with patterning defects: defects in T2, A5 and A8 mainly.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic/larval segmentation phenotype phenotype, enhanceable by Src64B[+]/Src64B^PI

(Sotillos et al., 2013)

Stat92E⁰⁶³⁴⁶ has abnormal mitotic cell cycle | maternal effect phenotype, enhanceable by Ras85D^ΔC40B

(Li et al., 2003)

Suppressed by

Statement

Reference

Stat92E⁰⁶³⁴⁶ has abnormal axis specification | embryonic stage phenotype, suppressible | partially by Scer\GAL4^Act5C.PU/drn^UAS.Tag:MYC

(Lai et al., 2023)

Enhancer of

Statement

Reference

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is an enhancer of decreased occurrence of cell division | third instar larval stage phenotype of Df(2L)BSC184/Kdm5¹⁰⁴²⁴

(Tarayrah et al., 2015)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is an enhancer of visible phenotype of Df(1)os¹

(Mukherjee et al., 2006)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Stat92E⁰⁶³⁴⁶ is an enhancer of abnormal mitotic cell cycle | maternal effect phenotype of Ras85D^ΔC40B

(Li et al., 2003)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is an enhancer of visible phenotype of Scer\GAL4^en-e16E, Socs36E^UASp.cCa

(Callus and Mathey-Prevot, 2002)

Stat92E⁰⁶³⁴⁶ is an enhancer of visible phenotype of Scer\GAL4^ey.PH, Su(var)2-10^537.UAS

(Betz et al., 2001)

NOT Enhancer of

Statement

Reference

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a non-enhancer of visible | adult stage phenotype of HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

Suppressor of

Statement

Reference

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of abnormal cell number | spermatogenesis phenotype of Scer\GAL4^{VP16.nanos.UTR}, Set1^HMS00581

(Vidaurre et al., 2024)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of visible | larval stage | heat sensitive phenotype of GCS1^Sz, hop^Sz

(Mortimer et al., 2021)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of melanotic mass phenotype | larval stage | heat sensitive phenotype of GCS1^Sz, hop^Sz

(Mortimer et al., 2021)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of visible | adult stage phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of abnormal size | third instar larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Tettweiler et al., 2019)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

Stat92E⁰⁶³⁴⁶, Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Wu et al., 2010)

Stat92E^F/Stat92E⁰⁶³⁴⁶ is a suppressor of abnormal size phenotype of L^fee

(Wang and Huang, 2009)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of abnormal cell migration | adult stage phenotype of apt^KG05830/apt¹⁶⁷

(Starz-Gaiano et al., 2008)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of hyperplasia | somatic clone | cell non-autonomous | adult stage phenotype of TSG101²

(Moberg et al., 2005)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of melanotic mass phenotype | dominant phenotype of hop^Tum

(Muller et al., 2005)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of hyperplasia | somatic clone | cell non-autonomous | wandering third instar larval stage phenotype of Vps25^A3

(Vaccari and Bilder, 2005)

Stat92E⁰⁶³⁴⁶ is a suppressor of melanotic mass phenotype | dominant | heat sensitive phenotype of hop^T42

(Luo et al., 1997)

Stat92E⁰⁶³⁴⁶ is a suppressor of increased mortality phenotype of hop^T42

(Luo et al., 1997)

Stat92E⁰⁶³⁴⁶ is a suppressor of melanotic mass phenotype phenotype of hop^Tum

(Hou et al., 1996)

Stat92E⁰⁶³⁴⁶ is a suppressor of partially lethal phenotype of hop^Tum

(Hou et al., 1996)

NOT Suppressor of

Statement

Reference

Stat92E⁰⁶³⁴⁶ is a non-suppressor of increased occurrence of cell division phenotype of hop^T42

(Luo et al., 1997)

Stat92E⁰⁶³⁴⁶ is a non-suppressor of increased occurrence of cell division phenotype of hop^Tum

(Luo et al., 1997)

Other

Statement

Reference

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic/larval segmentation phenotype phenotype

(Sotillos et al., 2013)

Stat92E⁰⁶³⁴⁶, scrib¹ has visible | somatic clone phenotype

(Wu et al., 2010)

Csk^j1D8, Stat92E⁰⁶³⁴⁶ has increased cell death phenotype

(Read et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic/larval spiracle phenotype, enhanceable by Src64B[+]/Src64B^PI

(Sotillos et al., 2013)

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic head phenotype, enhanceable by Src64B[+]/Src64B^PI

(Sotillos et al., 2013)

Stat92E⁰⁶³⁴⁶ has primordial germ cell | maternal effect phenotype, enhanceable by Ras85D^ΔC40B

(Li et al., 2003)

Stat92E⁰⁶³⁴⁶ has embryonic/larval posterior spiracle phenotype, enhanceable by dome^G0367

(Brown et al., 2001)

Suppressed by

Statement

Reference

Stat92E⁰⁶³⁴⁶ has embryonic/larval gut | embryonic stage phenotype, suppressible | partially by Scer\GAL4^Act5C.PU/drn^UAS.Tag:MYC

(Lai et al., 2023)

NOT suppressed by

Statement

Reference

Stat92E⁰⁶³⁴⁶ has abdominal 5 ventral denticle belt | germline clone | maternal effect phenotype, non-suppressible by Cdk4^hs.PC

(Chen et al., 2003)

Stat92E⁰⁶³⁴⁶ has abdominal 4 ventral denticle belt | germline clone | maternal effect phenotype, non-suppressible by Cdk4^hs.PC

(Chen et al., 2003)

Enhancer of

Statement

Reference

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is an enhancer of male germline stem cell | third instar larval stage phenotype of Df(2L)BSC184/Kdm5¹⁰⁴²⁴

(Tarayrah et al., 2015)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is an enhancer of eye phenotype of Df(1)os¹

(Mukherjee et al., 2006)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

Stat92E⁰⁶³⁴⁶ is an enhancer of eye-antennal disc | somatic clone phenotype of Csk^j1D8

(Read et al., 2004)

Stat92E⁰⁶³⁴⁶ is an enhancer of primordial germ cell | maternal effect phenotype of Ras85D^ΔC40B

(Li et al., 2003)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is an enhancer of wing phenotype of Scer\GAL4^en-e16E, Socs36E^UASp.cCa

(Callus and Mathey-Prevot, 2002)

Stat92E⁰⁶³⁴⁶ is an enhancer of eye phenotype of Scer\GAL4^ey.PH, Su(var)2-10^537.UAS

(Betz et al., 2001)

Stat92E⁰⁶³⁴⁶ is an enhancer of embryonic/larval posterior spiracle phenotype of dome^G0367

(Brown et al., 2001)

NOT Enhancer of

Statement

Reference

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a non-enhancer of eye phenotype of HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a non-enhancer of anterior crossvein phenotype of Scer\GAL4^en-e16E, Socs36E^UASp.cCa

(Callus and Mathey-Prevot, 2002)

Stat92E⁰⁶³⁴⁶, Scer\GAL4^30A is a non-enhancer of wing phenotype of Pka-C1^UAS.cKa, Scer\GAL4^30A

(Kiger et al., 2001)

Suppressor of

Statement

Reference

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of male germline stem cell phenotype of Scer\GAL4^{VP16.nanos.UTR}, Set1^HMS00581

(Vidaurre et al., 2024)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of embryonic/larval fat body | larval stage | heat sensitive phenotype of GCS1^Sz, hop^Sz

(Mortimer et al., 2021)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of eye phenotype of Hsap\ABL1::Hsap\BCR^UAS.cBa, Scer\GAL4^GMR.PU

(Bernardoni et al., 2019)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of wing disc | third instar larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Tettweiler et al., 2019)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of adult midgut epithelium phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of germarium phenotype of Scer\GAL4^C587, smo^JF02363

(Liu et al., 2015)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of spectrosome phenotype of Scer\GAL4^C587, smo^JF02363

(Liu et al., 2015)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of germarium phenotype of Scer\GAL4^C587, ci^GD1403

(Liu et al., 2015)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of spectrosome phenotype of Scer\GAL4^C587, ci^GD1403

(Liu et al., 2015)

Stat92E⁰⁶³⁴⁶, Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Wu et al., 2010)

Stat92E^F/Stat92E⁰⁶³⁴⁶ is a suppressor of eye phenotype of L^fee

(Wang and Huang, 2009)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of border follicle cell | oogenesis stage S10 phenotype of apt^KG05830/apt¹⁶⁷

(Starz-Gaiano et al., 2008)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of egg chamber | oogenesis stage S10 phenotype of apt^KG05830/apt¹⁶⁷

(Starz-Gaiano et al., 2008)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | maternal effect | partially of embryonic segment | maternal effect phenotype of Scer\GAL4^{VP16.mat.αTub67C}, tsl^UAS.cSa

(de las Heras and Casanova, 2006)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | maternal effect | partially of embryonic/first instar larval cuticle | maternal effect phenotype of Scer\GAL4^{VP16.mat.αTub67C}, tsl^UAS.cSa

(de las Heras and Casanova, 2006)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | maternal effect | partially of embryonic segment | maternal effect phenotype of cic¹/cic[+], tor^11D, trk¹

(de las Heras and Casanova, 2006)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | maternal effect | partially of embryonic/first instar larval cuticle | maternal effect phenotype of cic¹/cic[+], tor^11D, trk[+]/trk¹

(de las Heras and Casanova, 2006)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of eye | somatic clone phenotype of TSG101²

(Moberg et al., 2005)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of ommatidium | somatic clone | cell non-autonomous phenotype of TSG101²

(Moberg et al., 2005)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of melanotic mass phenotype of hop^Tum

(Muller et al., 2005)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor | partially of eye | somatic clone | cell non-autonomous phenotype of Vps25^A3

(Vaccari and Bilder, 2005)

Stat92E⁰⁶³⁴⁶ is a suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of tor^12D

(Li and Li, 2003)

Stat92E⁰⁶³⁴⁶/Stat92E⁰⁶³⁴⁶ is a suppressor of phenotype of tor^11D

(Li et al., 2002)

Stat92E⁰⁶³⁴⁶/Stat92E⁰⁶³⁴⁶ is a suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of tor^12D

(Li et al., 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of lamellocyte phenotype of Tl^10b

(Remillieux-Leschelle et al., 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of embryonic/larval plasmatocyte phenotype of Tl^10b

(Remillieux-Leschelle et al., 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of lamellocyte phenotype of hop^Tum

(Remillieux-Leschelle et al., 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of embryonic/larval plasmatocyte phenotype of hop^Tum

(Remillieux-Leschelle et al., 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a suppressor of embryonic/larval hemocyte phenotype of hop^Tum

(Remillieux-Leschelle et al., 2002)

Stat92E⁰⁶³⁴⁶ is a suppressor of phenotype of hop^T42

(Luo et al., 1997)

Stat92E⁰⁶³⁴⁶ is a suppressor of phenotype of hop^Tum

(Luo et al., 1997)

NOT Suppressor of

Statement

Reference

Stat92E⁰⁶³⁴⁶/Stat92E⁰⁶³⁴⁶ is a non-suppressor of ventral denticle belt | maternal effect phenotype of rl^Sem

(Li et al., 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a non-suppressor of embryonic/larval hemocyte phenotype of Tl^10b

(Remillieux-Leschelle et al., 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶ is a non-suppressor of embryonic/larval hemocyte phenotype of mxc^G43

(Remillieux-Leschelle et al., 2002)

Stat92E⁰⁶³⁴⁶, Scer\GAL4^30A is a non-suppressor of wing phenotype of Pka-C1^UAS.cKa, Scer\GAL4^30A

(Kiger et al., 2001)

Other

Statement

Reference

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic head phenotype

(Sotillos et al., 2013)

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic/larval spiracle phenotype

(Sotillos et al., 2013)

Stat92E⁰⁶³⁴⁶, scrib¹ has eye | somatic clone phenotype

(Wu et al., 2010)

Csk^j1D8, Stat92E⁰⁶³⁴⁶ has antenna | somatic clone phenotype

(Read et al., 2004)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa, Stat92E[+]/Stat92E⁰⁶³⁴⁶ has wing vein | ectopic phenotype

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa, Stat92E⁰⁶³⁴⁶ has wing vein | ectopic phenotype

(Callus and Mathey-Prevot, 2002)

Stat92E[+]/Stat92E⁰⁶³⁴⁶, da² has follicle cell phenotype

(Smith et al., 2002)

Stat92E⁰⁶³⁴⁶, da² has follicle cell phenotype

(Smith et al., 2002)

Scer\GAL4^ey.PH, Stat92E⁰⁶³⁴⁶, Su(var)2-10^537.UAS has antenna | ectopic phenotype

(Betz et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Stat92E⁰⁶³⁴⁶ heterozygosity suppresses the increased mitotic index in the adult midgut epithelium induced by the adulthood-only expression of Uvrag^HMS01357 under the control of Scer\GAL4^esg-NP5130 (and Gal80[ts], for the temporal control of expression).

(Nagy et al., 2016)

Stat92E⁰⁶³⁴⁶/+ suppresses the increased number of spectrosomes in the germaria of flies expressing smo^JF02363 under the control of Scer\GAL4^C587.

(Liu et al., 2015)

Stat92E⁰⁶³⁴⁶/+ enhances germline stem cell premature differentiation in lid¹⁰⁴²⁴/Df(2L)BSC184 third instar larval testes, with spermatocytes found in direct association with hub cells.

(Tarayrah et al., 2015)

Src42A^26-1/+ ; Stat92E⁰⁶³⁴⁶/+ double heterozygous embryos show defects in head formation and have segmentation and spiracle defects. This phenotype is enhanced if the embryos are also heterozygous for Src64B^PI.

(Sotillos et al., 2013)

Stat92E⁰⁶³⁴⁶ in eye-antennal disc clones that express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and in which adjacent cells are mutant for scrib¹, partially suppresses the overgrowth and completely abrogates the invasion of the nerve cord.

Stat92E⁰⁶³⁴⁶ partially suppresses the overgrowth and invasion of the nerve cord seen in scrib¹ mutant eye-antennal disc clones that simultaneously express Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

The eye is reduced in size when scrib¹ mutant clones are generated in eye-antennal discs in which adjacent cells are mutant for Stat92E⁰⁶³⁴⁶.

(Wu et al., 2010)

Eye size is almost restored to normal in L^fee; Stat92E⁰⁶³⁴⁶/Stat92E^F animals.

(Wang and Huang, 2009)

One copy of Stat92E⁰⁶³⁴⁶ partially suppresses the invasive border cell phenotype seen in apt^KG05830/apt¹⁶⁷ mutant stage 10 egg chambers. A reduction is seen in both the frequency of affected egg chambers and the number of cells. On average 26% of egg chambers contain "stretched border cells" compared to ~80% in apt^KG05830/apt¹⁶⁷ alone. The border cell cluster also detaches much more easily from the anterior end of the egg chamber.

(Starz-Gaiano et al., 2008)

Stat92E⁰⁶³⁴⁶/+ strongly suppresses the nonautonomous eye overgrowth phenotype due to mosaicism for TSG101².

(Moberg et al., 2005)

The upd1^GMR.PB eye overgrowth phenotype is significantly suppressed by one copy of Stat92E⁰⁶³⁴⁶. One copy of Stat92E⁰⁶³⁴⁶ reduces the size and the frequency of the melanotic tumours induced by hop^Tum/+.

(Muller et al., 2005)

Stat92E⁰⁶³⁴⁶/+ partially suppresses the overgrowth of wild-type adult eye tissue caused by Vps25^A3 homozygous somatic clones.

(Vaccari and Bilder, 2005)

Stat92E⁰⁶³⁴⁶. Csk^j1D8 mutant larval eye-antennal discs frequently show reduced sizes relative to the single mutants. Mutants also frequently show a reduction or absence of developing antennal tissues. Mutant larval eye tissue also contains many apoptotic cells.

(Read et al., 2004)

The large eye-phenotype observed in flies expressing upd1^Scer\UAS.cZa under the control of Scer\GAL4^GMR.PF is suppressed in a Stat92E⁰⁶³⁴⁶/+ background.

(Tsai and Sun, 2004)

The enlarged eye phenotype seen in flies carrying one copy of upd1^GMR.PB is strongly suppressed by one copy of Stat92E⁰⁶³⁴⁶.

(Bach et al., 2003)

The denticle belt defects seen in the cuticles of Stat92E⁰⁶³⁴⁶ germ-line clone embryos are not suppressed by Cdk4^hs.PC.

(Chen et al., 2003)

Embryos derived from double mutant Stat92E⁰⁶³⁴⁶; Ras85D^ΔC40B female germ line clones have 54% fewer pole cells by the cellularization stage than wild-type embryos, which is a greater reduction than is seen in embryos derived from either single mutant female germline clone. Pole cells of these double mutant embryos appear slightly larger than wild-type cells, consistent with their slower mitotic division rate.

(Li et al., 2003)

Expression of Socs36E^{Scer\UAS.P\T.cCa}, under the control of Scer\GAL4^en-e16E, in a Stat92E⁰⁶³⁴⁶/+ background results in an exacerbation of the outstretched wing phenotype seen in Socs36E^{Scer\UAS.P\T.cCa} expressing flies. The outgrowth appears to be made of wing material. The missing anterior crossvein phenotype is not affected. However, 60% of these flies show ectopic venation in the wing.

(Callus and Mathey-Prevot, 2002)

The segmentation phenotype seen in embryos derived from tor^12D/+ females is suppressed if the females also carry Stat92E⁰⁶³⁴⁶ homozygous germline clones. These embryos have phenotypes similar to embryos derived from Stat92E homozygous germline clones.

(Li et al., 2002)

The increased concentration of circulating hemocytes seen in mxc^G43 larvae is not suppressed by Stat92E⁰⁶³⁴⁶/+. The increased concentration of circulating hemocytes seen in Tl⁸/+ larvae is not suppressed by Stat92E⁰⁶³⁴⁶/+, but the increased numbers of podocytes and lamellocytes seen in Tl⁸/+ larvae are strongly suppressed by Stat92E⁰⁶³⁴⁶/+.

(Remillieux-Leschelle et al., 2002)

The addition of Stat92E⁰⁶³⁴⁶ significantly enhances the eye size and roughness seen in Su(var)2-10^537.Scer\UAS, Scer\GAL4^ey.PH flies. The enhancement frequently goes further, progeny grow antenna in place of eyes.

The addition of Su(var)2-10⁰³⁶⁹⁷ to Df(1)os¹ mutants leads to a slight suppression of the small eye phenotype seen in Df(1)os¹ flies. The further addition of Stat92E⁰⁶³⁴⁶ increases the suppression.

(Betz et al., 2001)

The weak posterior spiracle phenotype of dome^G0367 embryos is enhanced in dome^G0367; Stat92E⁰⁶³⁴⁶ double mutants.

(Brown et al., 2001)

Can suppress the premature differentiation and aggregation but not the overproliferation of hop^T42 or hop^Tum larval haemocytes.

(Luo et al., 1997)

Suppresses the dominant lethality and melanotic tumor phenotype of hop^Tum.

(Hou et al., 1996)

Xenogenetic Interactions

Statement

Reference

Heterozygosity for Stat92E⁰⁶³⁴⁶ does not modify the fully penetrant rough eye phenotype resulting from the co-expression of HPV18\E6^{Scer\UAS.T:Hsap\MYC} and Hsap\UBE3A^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PU, leading to severe eye necrosis.

(Padash Barmchi et al., 2016)

Complementation and Rescue Data

Fails to complement

Stat92E³⁹⁷

(Silver and Montell, 2001)

Stat92E^56D3

(Silver and Montell, 2001)

Stat92E^80A7

(Silver and Montell, 2001)

Stat92E^85C9

(Silver and Montell, 2001)

Stat92E^j6C8

(BDGP Project Members, 1994-1999)

Rescued by

Stat92E³⁹⁷/Stat92E⁰⁶³⁴⁶ is rescued by Stat92E^{sfGFP,Tag:FLAG}

(Sotillos et al., 2013)

Stat92E⁰⁶³⁴⁶ is rescued by Scer\GAL4^{VP16.mat.αTub67C}/Stat92E^UAS.cPa

(Bertet et al., 2009)

Partially rescued by

Stat92E^F/Stat92E⁰⁶³⁴⁶ is partially rescued by Stat92E^hs.PY

(Baksa et al., 2002)

Comments

Expression of Stat92E^Scer\UAS.cPa under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} rescues the germ-band extension defects observed in Stat92E⁰⁶³⁴⁶ germ-line clones.

(Bertet et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11681

ry⁵⁰⁶ P{PZ}Stat92E⁰⁶³⁴⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Separable from: esg⁰⁶³⁴⁶.

(Ashburner et al., 1999.10.12)

Comments

Precise excision of the P{PZ} is accompanied by reversion of the mutant phenotype.

(Hou et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (29)

Reported As

Symbol Synonym

D-Stat¹⁶⁸¹

(Luo et al., 1999)

D-stat⁶³⁴⁶

(Remillieux-Leschelle et al., 2002, Luo et al., 1997)

PZ06346

(Ashburner et al., 1999.10.12)

STAT92E⁰⁶³⁴⁶

(Bernardoni et al., 2019, Xie et al., 2017, Ren et al., 2015, Tsai et al., 2015, Tsai et al., 2007)

STAT92E^P1681

(Tsai and Sun, 2004)

STAT⁰⁶³⁴⁶

(Antel et al., 2022)

STAT⁰⁶⁴³⁶

(Angulo et al., 2019)

STAT¹⁶⁸¹

(Baksa et al., 2000)

Stat92E⁰⁶³⁴

(Decotto and Spradling, 2005)

Stat92E¹⁶⁸¹

(Borensztejn et al., 2013, Smith et al., 2002)

Stat92E^6346(P:lacZ)

(Sefton et al., 2000)

Stat92E⁶³⁴⁶

(Josten et al., 2004, Chen et al., 2003, Chen et al., 2002)

Stat92E^P1681

(Yu and Pan, 2018, Johansen et al., 2003)

Stat92e⁰⁶³⁴⁶

(McGregor et al., 2002)

l(3)06346

(Spradling et al., 1999)

l(3)06346⁰⁶³⁴⁶

mrl⁰⁶³⁴⁶

(Bertet et al., 2009, Li and Li, 2003)

mrl⁶³⁴⁶

(Sotillos et al., 2010, Li et al., 2002, Hou et al., 1996)

stat92E⁰⁶³⁴⁶

(Vidaurre et al., 2024, Enomoto et al., 2021, Chen et al., 2018, Hatini et al., 2013, Singh et al., 2011, Wu et al., 2010, Sheng et al., 2009, Luque and Milan, 2007, Arbouzova et al., 2006, de las Heras and Casanova, 2006, Ekas et al., 2006, Mukherjee et al., 2006, Brawley and Matunis, 2004, Bach et al., 2003, Henriksen et al., 2002, Kiger et al., 2001, Silver and Montell, 2001, Tulina and Matunis, 2001)

stat92E¹⁶⁸¹

(Luo et al., 1999)

stat92E⁶³⁴⁶

(Sotillos et al., 2013, Liu et al., 2009, Li et al., 2003, Baksa et al., 2002, Brown et al., 2001)

stat92E^P1681

(Harrison et al., 1998)

stat92E^mrl6346

(Lovegrove et al., 2006)

stat92e⁰⁶³⁴⁶

(Nagy et al., 2016, Liu et al., 2015, Santabárbara-Ruiz et al., 2015)

stat92e^P

(Liu et al., 2015)

stat⁰⁶³⁴⁶

(Tettweiler et al., 2019, Leatherman and DiNardo, 2008, Betz et al., 2001)

stat¹⁶⁸¹

(Chang et al., 2013, Starz-Gaiano et al., 2008, Silver et al., 2005, Callus and Mathey-Prevot, 2002)

stat^p1681

(Saha et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (99)

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