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General Information
Symbol
Dmel\jumu06439
Species
D. melanogaster
Name
FlyBase ID
FBal0009561
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
jumu11.683
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{PZ} insertion in the large first intron.

The P{PZ} insertion is at bp 538 (where 1 is at transcription start).

Insertion components
P{PZ}jumu06439
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The cardial cells (CCs) are unevenly distributed in mutant embryos: hemisegments having localised increases or decreases in CC number, occasional enlarged CC nuclei and CCs that are misaligned either with other CCs within a hemisegment or with their counterparts across the dorsal midline are seen.

The number of SELK neurons is normal in jumu06439 mutant animals.

When jumu06439 is added to WGMR.PH, grimGMR.PH or rprGMR.PH no effect is seen on the cell death phenotype in the eye.

Homozygous embryos occasionally show duplication of the RP2 neuron (expressivity of the phenotype is 4%).

Dominant suppressor of PEV in In(1)wm4.

jumu06439 wing disc cell clones induced at late embryonic to early larval stages are much smaller than their sibling clones when examined in late third-instar larvae. Small mutant clones are detected in adult wing blades, but no mutant cells are found in the wing margin or bristles on the notum. In eye discs, small mutant clones are formed in the regions anterior to the morphogenetic furrow, while no mutant clones are detected posterior to the morphogenetic furrow or in the adult eye.

Approximately 95% of jumu06439 embryos are defective in head involution, displaying an anterior open phenotype. Furthermore, about 35% of these flies show a defect in dorsal closure in addition the head involution defect. Incomplete germ band retraction is found in 20% of embryos. In jumu06439 embryos, the dorsal epidermal cells only partially elongate. These embryos exhibit loss of a large number of both CNS and PNS neurons. Occasionally, all or most of the CNS neurons in a hemisegment are lost.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference

jumu06439 is a non-suppressor of increased cell death phenotype of hidGMR.PH

jumu06439 is a non-suppressor of increased cell death phenotype of grimGMR.PH

jumu06439 is a non-suppressor of increased cell death phenotype of rprGMR.PH

Phenotype Manifest In
Enhancer of
Statement
Reference

jumu[+]/jumu06439 is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

NOT Suppressor of
Statement
Reference

jumu06439 is a non-suppressor of eye phenotype of hidGMR.PH

jumu06439 is a non-suppressor of eye phenotype of grimGMR.PH

jumu06439 is a non-suppressor of eye phenotype of rprGMR.PH

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Excision of the P{PZ} element can revert both the lethality and the duplicated RP2 neuron phenotype.

Fails to complement: stich1EP359. Fails to complement: stich1D233. Complements: Rfx253. Complements: l(3)A143.1F3A143.1F3.

Complements: pnt04877b. Complements: hth06762. Complements: l(3)j8B6j8B6.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
References (17)