P{PZ} insertion in the 5' untranslated region, 235bp upstream of the putative start codon.
abnormal memory | adult stage (with Atx2X1), with Atx2ΔcIDR
abnormal memory | adult stage (with Atx2X1), with Atx2ΔmIDR
nurse cell & actin filament | germ-line clone
nurse cell & nucleus | germ-line clone
Adult Atx2X1/Atx206490 transheterozygotes also bearing either Atx2ΔmIDR or Atx2ΔcIDR, but not Atx2+t10.4, exhibit significantly lower long-term olfactory habituation, as compared to controls.
Homozygous clones in the retina result in a mildly disorganised ommatidial pattern and a slight reduction in eye size. Females carrying homozygous germ line clones are completely sterile and fail to lay eggs. Most egg chambers in these females can proceed normally through the early and middle stages of oogenesis, but arrest at the stage when the nurse cells rapidly transfer their contents to the oocyte. The arrested egg chambers have enlarged nurse cells and a small poorly developed oocyte. The actin filaments that normally tether the nurse cell nuclei mostly fail to form. The nurse cell nuclei are inappropriately positioned close to the ring canals and are sometimes seen to stretch partially through the ring canals.
Atx2[+]/Atx206490 is an enhancer of abnormal locomotor rhythm | adult stage phenotype of Not1JF03096, Scer\GAL4P2.4.Pdf
Atx206490 is a suppressor of short lived | RU486 conditional phenotype of Hsap\ATXN7102Q.T.UAS.Tag:NLS(SV40-largeT), Scer\GAL4elav.Switch.PO
The poor rhythmicity of adult circadian locomotor activity under free-running (~constant darkness) conditions observed in flies expressing Not1JF03096 under the control of Scer\GAL4P2.4.Pdf is further worsened by combination with a single copy of Atx206490.
Atx2X1/Atx206490 is rescued by Atx2+t10.4
Atx2X1/Atx206490 is rescued by Atx2+t10.4
Atx206490 is rescued by Atx2UAS.cSa
Atx2X1/Atx206490 is not rescued by Atx2ΔLSM-Ad
The lethality of Atx2X1/Atx206490 mutants is rescues by Atx2+t10.4, Atx2ΔmIDR, Atx2ΔcIDR and partially rescued by Atx2ΔPam2 but is not rescued by Atx2ΔLSM-Ad or Atx2ΔLSM.
Expression of Atx2+t10.4 rescues the lethality of Atx2X1/Atx206490.
A. Spradling.
Precise excision of the P{PZ} element reverts the mutant phenotype.
Complements: Tm102299. Complements: l(3)j6A6j6A6. Complements: l(3)neo441. Complements: Tm1s2958.