Allele Dmel\Ras85D⁰⁶⁶⁷⁷

General Information
Symbol	Dmel\Ras85D⁰⁶⁶⁷⁷	Species	D. melanogaster
Name		FlyBase ID	FBal0009572
Feature type	allele	Associated gene	Dmel\Ras85D
Also Known As	l(3)06677⁰⁶⁶⁷⁷

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:5,338,088..5,338,088 (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{PZ}Ras85D⁰⁶⁶⁷⁷ (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Spradling et al., 1999) partially lethal - majority die partially lethal - majority die \| recessive (Berkeley Drosophila Genome Project, 1993.6.1) visible \| recessive (Berkeley Drosophila Genome Project, 1993.6.1)
Phenotype Manifest In
	tergite (Berkeley Drosophila Genome Project, 1993.6.1)
Detailed Description
	Statement Reference Homozygotes have etched tergites. (Berkeley Drosophila Genome Project, 1993.6.1)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Ras85D⁰⁶⁶⁷⁷/Ras85D[+] is a suppressor of lethal phenotype of Hsap\FOXO1::Hsap\PAX7^Scer\UAS.cGa, Scer\GAL4^Mhc.PW (Galindo et al., 2006) Ras85D⁰⁶⁶⁷⁷ is a suppressor of visible phenotype of Ret^MEN2A.GMR (Read et al., 2005) Ras85D⁰⁶⁶⁷⁷ is a suppressor of visible phenotype of Ret^MEN2B.GMR (Read et al., 2005)
Phenotype Manifest In
Suppressor of
Statement Reference Ras85D⁰⁶⁶⁷⁷/Ras85D[+] is a suppressor of embryonic/larval muscle system phenotype of Hsap\FOXO1::Hsap\PAX7^Scer\UAS.cGa, Scer\GAL4^Mhc.PW (Galindo et al., 2006) Ras85D⁰⁶⁶⁷⁷/Ras85D[+] is a suppressor of embryonic/larval somatic muscle phenotype of Hsap\FOXO1::Hsap\PAX7^Scer\UAS.cGa, Scer\GAL4^Mhc.PW (Galindo et al., 2006) Ras85D⁰⁶⁶⁷⁷ is a suppressor of eye phenotype of Ret^MEN2A.GMR (Read et al., 2005) Ras85D⁰⁶⁶⁷⁷ is a suppressor of eye phenotype of Ret^MEN2B.GMR (Read et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Heterozygosity for Ras85D^e2F, Ras85D^e1B or Ras85D⁰⁶⁶⁷⁷ suppresses the larval muscle phenotype seen in animals expressing Hsap\FOXO1A::Hsap\PAX7^Scer\UAS.cGa under the control of Scer\GAL4^Mhc.PW and also results in viable adult escapers. (Galindo et al., 2006)
Complementation & Rescue Data
Fails to complement	Ras85D^s1747 (BDGP Project Members, 1994-1999)
Comments
Stocks ( 1 )
Bloomington	11694 P{PZ}Ras85D⁰⁶⁶⁷⁷ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹
Notes on Origin
Discoverer	A. Spradling.

Comments
	Complements: pum⁰¹⁶⁸⁸. Complements: l(3)01728⁰¹⁷²⁸. Complements: Aats-trp⁰³⁵⁵⁹. Complements: Aats-trp⁰⁴⁴¹⁰. Complements: l(3)04837⁰⁴⁸³⁷. Complements: l(3)05430⁰⁵⁴³⁰. Complements: ps¹⁰⁶¹⁵. Complements: pum¹⁰⁶²⁵. Complements: l(3)L4092^L4091. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	l(3)06677 (Spradling et al., 1999) l(3)06677⁰⁶⁶⁷⁷ (Berkeley Drosophila Genome Project, 1993.6.1, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) Ras85^D06677 (Mahoney et al., 2006) Ras85D⁰⁶⁶⁷⁷ ras⁰⁶⁶⁷⁷ (Galindo et al., 2006)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Galindo et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(36): 13439--13444 A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR. [FBrf0192758] Mahoney et al., 2006, Genetics 172(4): 2309--2324 Presenilin-based genetic screens in Drosophila melanogaster identify novel Notch pathway modifiers. [FBrf0190744] Read et al., 2005, Genetics 171(3): 1057--1081 A Drosophila model of multiple endocrine neoplasia type 2. [FBrf0190765] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338] Berkeley Drosophila Genome Project, 1993.6.1, Insertion alleles. Insertion alleles. [FBrf0122635]

Allele Dmel\Ras85D06677

Allele Dmel\Ras85D⁰⁶⁶⁷⁷