Allele Dmel\klu⁰⁹⁰³⁶

General Information
Symbol	Dmel\klu⁰⁹⁰³⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0009610
Feature type	allele	Associated gene	Dmel\klu
Also Known As	P(9036), l(3)09036⁰⁹⁰³⁶

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3L:11,002,041..11,002,041 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Melcher and Pankratz, 2005, Parrish et al., 2009, Chen et al., 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{PZ}klu⁰⁹⁰³⁶ (BDGP Project Members, 1994-1999, Spradling et al., 1999, Melcher and Pankratz, 2005, Parrish et al., 2009, Chen et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	feeding behavior defective \| larval stage (Melcher and Pankratz, 2005) feeding behavior defective \| larval stage (with Df(3L)klu^XR19) (Melcher and Pankratz, 2005) feeding behavior defective \| larval stage (with klu^212lR51C) (Melcher and Pankratz, 2005) feeding behavior defective \| larval stage (with klu¹⁰⁰⁵²) (Melcher and Pankratz, 2005) lethal \| recessive (BDGP Project Members, 1994-1999, Spradling et al., 1999) neuroanatomy defective \| larval stage (with klu^212lR51C) (Xiao et al., 2012) small body \| larval stage (Melcher and Pankratz, 2005)
Phenotype Manifest In
	embryonic/larval neuroblast \| larval stage (with klu^212lR51C) (Xiao et al., 2012)
Detailed Description
	Statement Reference klu[212lR51C]/klu[09036] larval brains show premature loss of neuroblasts. (Xiao et al., 2012) Average Citrate Synthase activity is reduced by 8% in heterozygous males (Chen et al., 2008) klu⁰⁹⁰³⁶ mutant larvae are smaller than wild-type larvae and show a feeding defect in which they fail to pump food from the pharynx to the esophagus. This defect is not due to a morphological blockage in the esophagus and these larvae are able to move about with the same vigor as wild-type larvae. The mutant larvae display wandering behavior in which they leave the food source and move about with food lodged in their pharynx. This feeding phenotype is also seen in Df(3L)klu^XR19/klu⁰⁹⁰³⁶, klu^212lR51C/klu⁰⁹⁰³⁶ and klu¹⁰⁰⁵²/klu⁰⁹⁰³⁶ transheterozygotes. (Melcher and Pankratz, 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference klu⁰⁹⁰³⁶ has feeding behavior defective \| larval stage phenotype, suppressible by Ctet\TeTxLC^TNT.Scer\UAS/Scer\GAL4^S3.hug (Melcher and Pankratz, 2005)
Suppressor of
Statement Reference klu⁰⁹⁰³⁶ is a suppressor of visible phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005)
Phenotype Manifest In
Suppressor of
Statement Reference klu[+]/klu⁰⁹⁰³⁶ is a suppressor of eye phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PU (Protzer et al., 2008) klu⁰⁹⁰³⁶ is a suppressor of eye phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference The small-eye phenotype observed in animals expressing H[Scer\UAS.cMa] in the eye under the control of Scer\GAL4[GMR.PU] is significantly suppressed in a klu[09036]/+ mutant background. (Protzer et al., 2008)
Xenogenetic Interactions
Statement Reference Blocking synaptic transmission of "hug" neurons, achieved by expression of Ctet\TeTxLC^TNT.Scer\UAS under the control of Scer\GAL4^S3.hug, results in significant suppression of the klu feeding phenotype. (Melcher and Pankratz, 2005)
Complementation & Rescue Data
Fails to complement	klu^212lR51C (Melcher and Pankratz, 2005) klu¹⁰⁰⁵² (BDGP Project Members, 1994-1999, Melcher and Pankratz, 2005) klu^rJ903a (BDGP Project Members, 1994-1999)
Comments
Stocks ( 1 )
Bloomington	11733 P{PZ}klu⁰⁹⁰³⁶ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹
Notes on Origin
Discoverer	A. Spradling.

Comments
	Complements: l(3)01239⁰¹²³⁹. Complements: l(3)03691⁰³⁶⁹¹. Complements: l(3)01239^j9B4. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	klu⁰⁹⁰³⁶ (Christensen et al., 2008.12.28, Protzer et al., 2008, Xiao et al., 2012) klu⁹⁰³⁶ (Chen et al., 2008) l(3)09036 (Spradling et al., 1999) l(3)09036⁰⁹⁰³⁶ (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) P09036 (Makunin et al., 2002) P(9036) (Melcher and Pankratz, 2003, Melcher and Pankratz, 2001)
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Xiao et al., 2012, Development 139(15): 2670--2680 klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division. [FBrf0218804] Parrish et al., 2009, Neuron 63(6): 788--802 The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. [FBrf0208858] Chen et al., 2008, Genome Res. 18(1): 123--136 Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. [FBrf0202125] Protzer et al., 2008, J. Cell Sci. 121(19): 3167--3176 Hairless induces cell death by downregulation of EGFR signalling activity. [FBrf0207053] Melcher and Pankratz, 2005, PLoS Biol. 3(9): e305 Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain. [FBrf0188215] Mueller et al., 2005, Genetics 171(3): 1137--1152 Genetic modifier screens on hairless gain-of function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. [FBrf0190751] Makunin et al., 2002, Genetics 160(3): 1023--1034 The Drosophila suppressor of underreplication protein binds to late-replicating regions of polytene chromosomes. [FBrf0147054] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Personal communication to FlyBase	Christensen et al., 2008.12.28, Isolation and characterization of Df(3L)BSC674. Isolation and characterization of Df(3L)BSC674. [FBrf0206422] Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
Abstract	Melcher and Pankratz, 2003, Europ. Dros. Res. Conf. 18: K03 Physiological and morphological analysis of the feeding mutant P(9036): the roles of klumpfuss and hugin in central regulation of feeding and growth. [FBrf0161835] Melcher and Pankratz, 2001, Europ. Dros. Res. Conf. 17: F23 Molecular and physiological analysis of klumpfuss (klu), a gene involved in central regulation of food intake and growth. [FBrf0137994]

Allele Dmel\klu09036

Allele Dmel\klu⁰⁹⁰³⁶