FB2025_01 , released February 20, 2025
Allele: Dmel\klu09036
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General Information
Symbol
Dmel\klu09036
Species
D. melanogaster
Name
FlyBase ID
FBal0009610
Feature type
allele
Associated gene
Dmel\klu
Associated Insertion(s)
P{PZ}klu09036
Carried in Construct
Also Known As
Klu09036-lacZ, klumpfuss09036
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{PZ}klu09036
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      klu09036 larvae buildup food in the midgut.

      (Myers et al., 2018)

      klu09036 first instar larvae ingest significantly less food than wild type in a liquid food assay.

      (Gasque et al., 2013)

      klu212lR51C/klu09036 larval brains show premature loss of neuroblasts.

      (Xiao et al., 2012)

      Average Citrate Synthase activity is reduced by 8% in heterozygous males

      (Chen et al., 2008)

      klu09036 mutant larvae are smaller than wild-type larvae and show a feeding defect in which they fail to pump food from the pharynx to the esophagus. This defect is not due to a morphological blockage in the esophagus and these larvae are able to move about with the same vigor as wild-type larvae. The mutant larvae display wandering behavior in which they leave the food source and move about with food lodged in their pharynx. This feeding phenotype is also seen in Df(3L)kluXR19/klu09036, klu212lR51C/klu09036 and klu10052/klu09036 transheterozygotes.

      (Melcher and Pankratz, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Statement
      Reference

      klu09036 is a suppressor of visible phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      klu[+]/klu09036 is a suppressor of eye phenotype of HUAS.cMa, Scer\GAL4GMR.PU

      (Protzer et al., 2008)

      klu09036 is a suppressor of eye phenotype of HUAS.cMa, Scer\GAL4GMR.PF

      (Müller et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small-eye phenotype observed in animals expressing HScer\UAS.cMa in the eye under the control of Scer\GAL4GMR.PU is significantly suppressed in a klu09036/+ mutant background.

      (Protzer et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference

      Blocking synaptic transmission of "hug" neurons, achieved by expression of Ctet\TeTxLCTNT.Scer\UAS under the control of Scer\GAL4S3.hug, results in significant suppression of the klu feeding phenotype.

      (Melcher and Pankratz, 2005)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Complements: l(3)0123901239. Complements: l(3)0369103691. Complements: l(3)01239j9B4.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (8)
      References (16)