Developmental arrest at first larval instar.
Females containing homozygous germline clones are sterile with no germ cell development.
Homozygotes generally die during embryogenesis, although some individuals survive up to the state of early first instar larvae.
Homozygous embryos show widespread DNA fragmentation from stage 10 to 12 compared to control embryos, indicating increased cell death.
Development is arrested in the first larval instar, although the larvae survive for several days. Developmental delay with eIF-4ESer251Ala.t8.9 is 1 to 2 days.
Hemizygotes die as embryos.