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General Information
Symbol
Dmel\eIF4E167Af
Species
D. melanogaster
Name
FlyBase ID
FBal0009716
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)67Af1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
G9400954A
Amino acid change:
G?A
Comment:
A AG to AA mutation in the splice acceptor site of the second intron.
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Point mutation (G to A) in the splice acceptor site of the second intron. This mutation is predicted to result in a nonsense reading of the open reading frames of both the eIF-4E 1 and 2 isoforms.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Developmental arrest at first larval instar.
Females containing homozygous germline clones are sterile with no germ cell development. Homozygotes generally die during embryogenesis, although some individuals survive up to the state of early first instar larvae. Homozygous embryos show widespread DNA fragmentation from stage 10 to 12 compared to control embryos, indicating increased cell death.
Development is arrested in the first larval instar, although the larvae survive for several days. Developmental delay with eIF-4ESer251Ala.t8.9 is 1 to 2 days.
Hemizygotes die as embryos.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Partial suppression of eIF-4EScim-a/eIF-4E67Af lethality by Lk6Scer\UAS.cAa results in pseudopupae, whereas with Lk6EP3333 small abortive pupae and pharate adults result. Weak rescue of eIF-4EScim-a/eIF-4E67Af by eIF-4ES251A.Scer\UAS is not improved by Lk6T424D.Scer\UAS.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Matthews.
Comments
Comments
Relatively weak allele.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)