Allele Dmel\hyd¹⁵

General Information
Symbol	Dmel\hyd¹⁵	Species	D. melanogaster
Name		FlyBase ID	FBal0010246
Feature type	allele	Associated gene	Dmel\hyd

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	cytokinesis defective (with hyd^C017) (Pertceva et al., 2010) viable (with hyd^C017) (Pertceva et al., 2010)
Phenotype Manifest In
	centrosome (with hyd^C017) (Pertceva et al., 2010) elongation stage spermatid (with hyd^C017) (Pertceva et al., 2010) meiotic primary spermatocyte (with hyd^C017) (Pertceva et al., 2010) nucleus (with hyd^C017) (Pertceva et al., 2010) primary spermatocyte cyst (with hyd^C017) (Pertceva et al., 2010) spindle (with hyd^C017) (Pertceva et al., 2010)
Detailed Description
	Statement Reference hyd[15]/hyd[C017] mutants exhibit abnormalities in spermatogenesis. One such abnormality is for nuclei scattered through the elongated cysts to exhibit a round shape instead of a 'needle' shape. In rare cases, the group of needle-shaped nuclei can be found in the correct place in the cyst; however, some of the nuclei are evidently incorrectly condensed. Approximately 90% of nuclei and micronuclei do not reach the correct cyst pole. hyd[15]/hyd[C017] mutant spermatocytes exhibit defects in cytokinesis such as the formation of two spindles in one meiotic cell. The meiotic products may have unequal amounts of chromatin or mitochondrial material. Centrosome behavior is also affected. Meiotic chromosomes are not correctly attached to the spindle in 50% of hyd[15]/hyd[C017] spermatids. (Pertceva et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference hyd¹⁵ has cytokinesis defective phenotype, enhanceable by pAbp[+]/pAbp^k10109 (Pertceva et al., 2010)
Enhancer of
Statement Reference hyd[+]/hyd¹⁵ is an enhancer of cytokinesis defective phenotype of pAbp^k10109 (Pertceva et al., 2010)
NOT Enhancer of
Statement Reference hyd[+]/hyd¹⁵ is a non-enhancer of visible phenotype of CycE^JP (Brumby et al., 2004)
NOT Suppressor of
Statement Reference hyd[+]/hyd¹⁵ is a non-suppressor of visible phenotype of CycE^JP (Brumby et al., 2004)
Phenotype Manifest In
Enhancer of
Statement Reference hyd¹⁵ is an enhancer of wing vein \| ectopic phenotype of Cbl^Dv.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Robertson et al., 2000)
NOT Enhancer of
Statement Reference hyd[+]/hyd¹⁵ is a non-enhancer of eye phenotype of CycE^JP (Brumby et al., 2004)
Suppressor of
Statement Reference hyd¹⁵ is a suppressor of arista \| supernumerary phenotype of obk¹ (Atallah et al., 2004)
NOT Suppressor of
Statement Reference hyd[+]/hyd¹⁵ is a non-suppressor of eye phenotype of CycE^JP (Brumby et al., 2004)
Other
Statement Reference hyd[+]/hyd¹⁵, pAbp^k10109 has elongation stage spermatid phenotype (Pertceva et al., 2010) hyd[+]/hyd¹⁵, pAbp^k10109 has nucleus phenotype (Pertceva et al., 2010) hyd¹⁵, pAbp[+]/pAbp^k10109 has elongation stage spermatid phenotype (Pertceva et al., 2010) hyd¹⁵, pAbp[+]/pAbp^k10109 has nucleus phenotype (Pertceva et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference pAbp[k10109]/hyd[15] trans-heterozygous double mutants exhibit spermatogenesis defects. The morphology of nuclei in the sperm head bundle are indistinguishable from the control but the nuclei are frequently scattered abnormally. Cytokinetic abnormalities are also increased in these double mutants. (Pertceva et al., 2010) The extent of ectopic wing vein formation found in Scer\GAL4[GMR.PF] Cbl[Dv.Scer\UAS] flies is enhanced in a hyd[15] mutant background but does not affect the eye roughening phenotype. (Robertson et al., 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	3718 kni^ri-1 hyd¹⁵ e¹/TM3, Sb¹
Kyoto	107197 kni^ri-1 hyd¹⁵ e¹/TM3, Sb¹
Notes on Origin
Discoverer	Matthews.

Comments
	Complements: knk^ex59. (Beitel and Krasnow, 2000)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	hyd¹⁵ (Robertson et al., 2000, Pertceva et al., 2010) l(3)18
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Pertceva et al., 2010, Cell Biol. Int. 34(10): 991--996 The role of Drosophila hyperplastic discs gene in spermatogenesis. [FBrf0211767] Atallah et al., 2004, Evol. Dev. 6(2): 114--122 The environmental and genetic regulation of obake expressivity: morphogenetic fields as evolvable systems. [FBrf0178980] Brumby et al., 2004, Genetics 168(1): 227--251 A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. [FBrf0180291] Beitel and Krasnow, 2000, Development 127(15): 3271--3282 Genetic control of epithelial tube size in the Drosophila tracheal system. [FBrf0128394] Robertson et al., 2000, Oncogene 19(29): 3299--3308 A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo. [FBrf0130045]

Allele Dmel\hyd15

Allele Dmel\hyd¹⁵