Open Close
General Information
Symbol
Dmel\CtBP87De-10
Species
D. melanogaster
Name
FlyBase ID
FBal0010480
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dCtBP87De-10, CtBPl(3)87De-10
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C13021037T

Reported nucleotide change:

C?T

Amino acid change:

Q229term | CtBP-PA; Q229term | CtBP-PB; Q229term | CtBP-PC; Q229term | CtBP-PD; Q229term | CtBP-PE; Q229term | CtBP-PF; Q229term | CtBP-PG; Q229term | CtBP-PH; Q229term | CtBP-PI; Q229term | CtBP-PJ

Reported amino acid change:

Q229term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C?T.

Amino acid replacement: Q229term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

CtBP87De-10/+ adult flies have one trichogen (hair) and one tormogen (socket) cell per notal microchaeta, similar to wild-type controls.

CtBP03463/CtBP87De-10 heterozygous pharates display extra dorsal thoracic mechanosensory bristles (additional bristles attached to sockets) and, less frequently, double bristles (two bristles housed in the same socket structure) and bald cuticle (complete loss of both bristles and their associated sockets). Only a subset of bristles are affected.

Within CtBP87De-10 dorsal thorax clones, extra bristles, double bristles forming from the same socket, bald cuticle, and sockets lacking bristles are observed. All but the presutural bristle appear to be affected. The double bristle phenotypes appear exclusively at the anterior scutellar bristle and posterior dorsocentral bristle positions. Bald cuticle appears in all regions except the posterior postalar bristle and presutural regions. Socket without bristle phenotype is observed for all positions except the presutural position.

A putative cell polarity abnormality of the microchaetes is observed in CtBP87De-10 dorsal thorax clones.

CtBP87De-10 mutant cyst progenitor cell clones cannot be recovered.

About 65% of CtBP87De-10, CtBPUbi.T:Hsap\MYC flies show an extra macrochaete phenotype on the dorsal thorax.

Heterozygotes occasionally have bristle with a double-socket phenotype. CtBP03463/CtBP87De-10 pharate adults show bristle shaft defects and shaft loss.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

CtBP[+]/CtBP87De-10 is an enhancer of visible phenotype of upd11

CtBP[+]/CtBP87De-10 is an enhancer of visible phenotype of Su(H)RC-9Xm

CtBP[+]/CtBP87De-10 is an enhancer of visible | dominant phenotype of HE31

NOT Enhancer of
Statement
Reference

CtBP[+]/CtBP87De-10 is a non-enhancer of visible phenotype of upd1GMR.PB

CtBP[+]/CtBP87De-10 is a non-enhancer of visible phenotype of H21

CtBP[+]/CtBP87De-10 is a non-enhancer of visible phenotype of H21, groE73/gro[+]

Suppressor of
Statement
Reference

CtBP[+]/CtBP87De-10 is a suppressor | partially of visible | heat sensitive phenotype of Nl1N-ts1

NOT Suppressor of
Statement
Reference

CtBP[+]/CtBP87De-10 is a non-suppressor of visible phenotype of upd1GMR.PB

CtBP[+]/CtBP87De-10 is a non-suppressor of visible phenotype of H21

CtBP[+]/CtBP87De-10 is a non-suppressor of visible phenotype of H21, groE73/gro[+]

Phenotype Manifest In
Enhancer of
Statement
Reference

CtBP[+]/CtBP87De-10 is an enhancer of eye phenotype of upd11

CtBP[+]/CtBP87De-10 is an enhancer of macrochaeta phenotype of Su(H)RC-9Xm

CtBP[+]/CtBP87De-10 is an enhancer of anterior orbital bristle phenotype of HE31

CtBP[+]/CtBP87De-10 is an enhancer of macrochaeta phenotype of HE31

CtBP[+]/CtBP87De-10 is an enhancer of eye phenotype of Scer\GAL4hs.2sev, ttk69.UAS.Tag:HA

NOT Enhancer of
Statement
Reference

CtBP[+]/CtBP87De-10 is a non-enhancer of eye phenotype of upd1GMR.PB

CtBP[+]/CtBP87De-10 is a non-enhancer of macrochaeta phenotype of H21

CtBP[+]/CtBP87De-10 is a non-enhancer of macrochaeta phenotype of H21, groE73/gro[+]

Suppressor of
NOT Suppressor of
Statement
Reference

CtBP[+]/CtBP87De-10 is a non-suppressor of eye phenotype of upd1GMR.PB

CtBP[+]/CtBP87De-10 is a non-suppressor of macrochaeta phenotype of H21

CtBP[+]/CtBP87De-10 is a non-suppressor of macrochaeta phenotype of H21, groE73/gro[+]

Other
Additional Comments
Genetic Interactions
Statement
Reference

CtBP87De-10 combined with h41, ttkrM730 or Df(3R)awd-KRB leads to an ectopic margin bristle phenotype.

CtBP87De-10 dominantly enhances the bristle defects seen in HE31/+ flies. This enhancement is almost entirely due to shaft-socket transformations, with only a mild effect on bristle loss.

Some of the eye phenotypes caused by expression of ttk69.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.2sev are enhanced by one copy of CtBP87De-10.

Xenogenetic Interactions
Statement
Reference

Atha\ANUbi.T:Hsap\MYC fails to rescue CtBP87De-10 zygotic lethality.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Gelbart.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (12)
References (24)