Allele Dmel\InR^93Dj-1

General Information
Symbol	Dmel\InR^93Dj-1	Species	D. melanogaster
Name		FlyBase ID	FBal0010752
Feature type	allele	Associated gene	Dmel\InR
Also Known As	InR^EC34, EC34

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Mohler and Pardue, 1984)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	female sterile (with InR^E19) (Tatar et al., 2001) female sterile \| recessive (Chen et al., 1996) lethal \| recessive (Chen et al., 1996, Mohler and Pardue, 1984) short lived (with InR^E19) (Tatar et al., 2001) small body (with InR^E19) (Tatar et al., 2001) stress response defective (Vigne et al., 2009) visible (Chen et al., 1996)
Phenotype Manifest In
	eye-antennal disc (Chen et al., 1996) haltere disc (Chen et al., 1996) mesothoracic leg disc (Chen et al., 1996) metathoracic leg disc (Chen et al., 1996) ovariole (Chen et al., 1996) ovary (Chen et al., 1996) wing disc (Chen et al., 1996)
Detailed Description
	Statement Reference In a fed state, InR[93Dj-1] flies are anoxia tolerant. (Vigne et al., 2009) InR^93Dj-1/InR^E19 adults are dwarf in size and are short-lived; life expectancy of both males and females is reduced compared to controls (from 32.3 to 2.3 and from 35.5 to 1.4 days respectively). (Tatar et al., 2001) Heterozygous adults have slightly reduced body size. Many InR^93Dj-1/InR^E19 animals survive to adulthood. They eclose with a delay of 8 to 9 days at 25^oC, having prolonged second and third larval instar stages compared to control siblings. The number of cells in the wing, eye-antennal, haltere, mesothoracic leg and metathoracic leg discs is reduced compared to wild-type. Pupae and adult flies are reduced in size compared to wild-type. InR^93Dj-1/InR^E19 males are fertile, but InR^93Dj-1/InR^E19 females are unable to produce eggs. Ovaries are reduced in size, do not contain mature eggs and remain unchanged in size at 7, 10 and 14 days after eclosion. The rate of ovariole maturation is slower than wild-type and ovarioles never mature to the stage of egg deposition. (Chen et al., 1996)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially complements	InR^E19 (Chen et al., 1996)
Fails to complement	InR^E16 (Chen et al., 1996) InR^E21 (Chen et al., 1996)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	EC34 (Chen et al., 1996, Mohler and Pardue, 1984) InR^93Dj-1 InR^EC34 (Tatar et al., 2001) Inr^EC34 (Clancy et al., 2001) InREC34 (Vigne et al., 2009) l(3)93Dj¹ l(3)er10^EC34
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Vigne et al., 2009, PLoS ONE 4(5): e5422 Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries. [FBrf0207966] Clancy et al., 2001, Science 292(5514): 104--106 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. [FBrf0135946] Tatar et al., 2001, Science 292(5514): 107--110 A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. [FBrf0135947] Chen et al., 1996, Endocrinology 137(3): 846--856 The Drosophila insulin receptor is required for normal growth. [FBrf0086349] Mohler and Pardue, 1984, Genetics 106(2): 249--265 Mutational analysis of the region surrounding the 93D heat shock locus of Drosophila melanogaster. [FBrf0040940]

Allele Dmel\InR93Dj-1

Allele Dmel\InR^93Dj-1