FB2025_01 , released February 20, 2025
Allele: Dmel\Sec23j13C8
Open Close
General Information
Symbol
Dmel\Sec23j13C8
Species
D. melanogaster
Name
FlyBase ID
FBal0010891
Feature type
allele
Associated gene
Dmel\Sec23
Associated Insertion(s)
P{lacW}Sec23j13C8
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
Progenitor genotype
Associated Insertion(s)
P{lacW}Sec23j13C8
Cytology
Description

P{lacW} insertion within the 5'UTR.

(Levis, 2002.12.19)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The accumulation of en-positive granules in the salivary glands is not altered detectably in sec23j13C8 mutants. sec23j13C8 mutants have major defects in cuticular development; the larval cuticles are smaller (on average only 40-50% the length of wild-type) and weaker than the cuticles of their wild-type siblings, the mouthparts and filzkorper are poorly formed, and sec23j13C8 mutants frequently have large holes in the dorsal cuticle. In addition, there appears to be a general defect in patterning of the cuticle, with dorsal and ventral structures appearing more lateralized. The ventral cuticle exhibits a loss of denticles and the denticles that are present have a very light pigmentation, more consistent with the pigmentation found in more lateral denticles of wild-type larvae. The dorsal surfaces of the mutant larvae consist of thin hairs and naked cuticle, an arrangement more typical of dorsal-lateral reiogns of wild-type cuticles.

      (Abrams and Andrew, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Sec23[+]/Sec23j13C8 is a non-enhancer of visible | adult stage phenotype of dpyD

      (Kandasamy et al., 2021)

      Sec23[+]/Sec23j13C8 is a non-enhancer of decreased size | adult stage phenotype of dpyD

      (Kandasamy et al., 2021)
      NOT Suppressor of
      Statement
      Reference

      Sec23[+]/Sec23j13C8 is a non-suppressor of visible | adult stage phenotype of dpyD

      (Kandasamy et al., 2021)

      Sec23[+]/Sec23j13C8 is a non-suppressor of decreased size | adult stage phenotype of dpyD

      (Kandasamy et al., 2021)
      Other
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Sec23[+]/Sec23j13C8 is a non-enhancer of wing phenotype of dpyD

      (Kandasamy et al., 2021)
      NOT Suppressor of
      Statement
      Reference

      Sec23[+]/Sec23j13C8 is a non-suppressor of wing phenotype of dpyD

      (Kandasamy et al., 2021)
      Other
      Statement
      Reference

      Sec23[+]/Sec23j13C8, Yif1doc-1 has wing phenotype

      (Kandasamy et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sec23j13C8, Yif1doc-1 double heterozygotes show a small, oblique wing phenotype.

      (Kandasamy et al., 2021)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      L. and Y. Jan.

      Separable from: l(3)j13C8j13C8.

      (DeBruhl, 2014.2.5)

      The lethality of the "l(3)j13C8" line does not appear to be due to disruption of Sec23 function: the chromosome is not lethal in combination either Sec239G or with Df(3R)ED5187 (a deficiency that deletes Sec23). This suggests that the lethality (represented by l(3)j13C8j13C8) is separable from the P{lacW}Sec23j13C8 insertion in Sec23.

      (DeBruhl, 2014.2.5)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sec23j13C8
      (DeBruhl, 2014.2.5)
      sec23j13C8
      (Kandasamy et al., 2021, González-Morales et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)