FlyBase Allele Report: Dmel\Rab11[j2D1]

(Gao et al., 2022, Dollar et al., 2002, Jankovics et al., 2001, Spradling et al., 1999, Braun et al., 1997, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

actin cytoskeleton | embryonic stage (with Rab11^93Bi)

(Riggs et al., 2003)

egg

(Perrimon et al., 1996)

egg | germline clone

(Jankovics et al., 2001)

germline cell (with Rab11^93Bi)

(Jankovics et al., 2001)

macrochaeta (with Rab11^93Bi)

(Jankovics et al., 2001)

nucleus | embryonic stage (with Rab11^93Bi)

(Riggs et al., 2003)

Detailed Description

Statement

Reference

Embryo hatching rate is massively reduced in Rab11^93Bi/Rab11^j2D1 mutants (around 10% hatch) compared to wild type.

(Zheng et al., 2016)

Rab11^j2D1 germline stem cells have a half life similar to wild type.

(Bogard et al., 2007)

Rab11^j2D1/+ flies show no eye phenotype.

(Khodosh et al., 2006)

Eyes composed of homozygous clones (generated using the EGUF/hid method) have normal architecture.

Rab11^mo/Rab11^j2D1 flies have normal eyes.

(Alone et al., 2005)

In Rab11^93Bi/Rab11^j2D1-derived embryos, in premigration and early cortical embryos, 8% exhibit disrupted nuclear morphology. During the late cortical divisions, when the nuclei are more densely packed, 65% exhibit severely disrupted nuclear morphology. In Rab11^93Bi/Rab11^j2D1-derived embryos, actin cap formation occurs normally. As the embryos progress into prophase, the actin caps are dismantled and actin re-organises into furrows encompassing each prophase nucleus and its developing spindle. In Rab11^93Bi/Rab11^j2D1-derived embryos, the hexagonal furrow network is riddled with gaps, present at prophase during the initial stages of furrow formation. Similar defects are observed during cellularisation at nuclear cycle 14.

(Riggs et al., 2003)

Development is arrested during mid-embryogenesis in homozygous mutant germ-line clones. Mutant germ-line clones have a normal organisation of microtubules minus ends.

(Dollar et al., 2002)

7.7% of eggs laid by Rab11^93Bi/Rab11^j2D1 females develop into larvae. 2% of the escapers have a germ cell-less phenotype. Eggs derived from homozygous female germline clones often collapse and never develop into larvae.

(Jankovics et al., 2001)

Germline clones produce abnormal eggs due to abnormal oogenesis: eggs are collapsed.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rab11^93Bi/Rab11^j2D1 has majority die during embryonic stage phenotype, enhanceable by Nin¹