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General Information
Symbol
Dmel\dcoj3B9
Species
D. melanogaster
Name
FlyBase ID
FBal0010937
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dbtP
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} is inserted between exons II and III.

Insertion components
P{lacW}dcoj3B9
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The rough eye phenotype observed in Fmr1sev.PW flies is suppressed in a dcoj3B9/+ background.

Clones of dcoj3B9 are small.

dcoj3B9 clones (generated by the Minute technique) induced in the wing show loss of margin bristles and/or parts of the wing margin. dcoj3B9 clones also show autonomous planar cell polarity wing hair defects. dcoj3B9 Minute clones in the eye show strong planar cell polarity defects.

The eyes of dcoj3B9/dcoar transheterozygotes show mild planar cell polarity defects.

In dcoj3B9 mutant clones in the pupal wing, trichome initiation is delayed and prehairs often emerge from the cell centre instead of the distal edge.

About 2/3 of dcoar/dcoj3B9 flies are arrhythmic, the rest show a period-lengthening phenotype.

Short rhythm mutant.

Homozygous embryos take longer to develop than heterozygous siblings. Foraging motility and touch sensitivity appear normal. The larval lateral neurons (lvLNs) are found slightly more peripherally than in wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

dcoj3B9/dco[+] is an enhancer of abnormal cell polarity phenotype of fz20/fz19

Suppressor of
Statement
Reference

dcoj3B9/dco[+] is a suppressor | partially of abnormal cell polarity phenotype of fzhs.sev

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

dcoj3B9/dco[+] is an enhancer of ommatidium phenotype of Scer\GAL4hs.2sev, VangUAS.cWa

dcoj3B9/dco[+] is an enhancer of ommatidium phenotype of fz20/fz19

Suppressor of
Statement
Reference

dcoj3B9/dco[+] is a suppressor of eye phenotype of Fmr1sev.PW

dcoj3B9/dco[+] is a suppressor | partially of ommatidium phenotype of fzhs.sev

Other
Additional Comments
Genetic Interactions
Statement
Reference

Adult-specific expression (using TubGAL80ts) of larkScer\UAS.T:Ivir\HA1 driven by Scer\GAL4P2.4.Pdf significantly lengthens circadian period in dcoj3B9/+ flies; co-expression of larkdsRNA.Scer\UAS.cSb significantly shortens circadian period.

Expression of Nek2dsRNA.Scer\UAS.cUa under the control of Scer\GAL4sd.PU in a dcoj3B9/+ background results in loss of sensory bristles along the wing margin.

The planar polarity defects seen in the eyes of fzhs.sev/+ flies are significantly suppressed in fzhs.sev/+, dcoj3B9/+ flies, although the eyes do not appear wild type.

The planar polarity defects seen in the eye when VangScer\UAS.cWa is expressed under the control of Scer\GAL4hs.2sev in a wild-type background are significantly enhanced in a dcoj3B9/+ background.

Expression of dshScer\UAS.cNa under the control of Scer\GAL4hs.2sev in a dcoj3B9/+ background results in a strong suppression of the loss of photoreceptor cell phenotype seen when the transgene is expressed in a wild-type background.

The ommatidial polarity defects of fz19/fz20 mutants are enhanced in fz19/fz20, dcoj3B9/+ double mutants.

The addition of pers or perT to dcoj3B9/dcoar flies suppresses the arrhythmicity phenotype seen in these flies. The addition of timS1/tim01, tim01/+, or perSLIH does not suppress the dcoar/dcoj3B9 and dcoar/Df(3R)tll-g arrhythmic phenotypes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

L. and Y. Jan.

Comments
Comments

Reversion analysis confirms that the P{lacW} insertion is the cause of both the pupal lethality and the aberrant circadian rhythmicity.

After six generations of outcrossing the lethality continued to segragate with the P{lacW} insertion.

Complements: l(3)0072000720. Complements: l(3)0367003670. Complements: Aph-407028.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (30)