Allele Dmel\th^j5C8

General Information
Symbol	Dmel\th^j5C8	Species	D. melanogaster
Name		FlyBase ID	FBal0010971
Feature type	allele	Associated gene	Dmel\th
Also Known As	l(3)j5C8, th^j5c8

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3L:16,039,894..16,039,894 (Hay et al., 1995, BDGP Project Members, 1994-1999, Huang et al., 2005, Geisbrecht and Montell, 2004, Lai et al., 2005, Braun et al., 1997, Wu et al., 2003, Spradling et al., 1999, Chen et al., 2008, Cooper and Kennison, 2011, Verghese et al., 2012)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{lacW} is inserted in 5' untranslated region of th. (Hay et al., 1995)
Caused by insertion	P{lacW}th^j5C8 (Hay et al., 1995, BDGP Project Members, 1994-1999, Huang et al., 2005, Geisbrecht and Montell, 2004, Lai et al., 2005, Braun et al., 1997, Wu et al., 2003, Spradling et al., 1999, Chen et al., 2008, Cooper and Kennison, 2011, Verghese et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Spradling et al., 1999, Hay et al., 1995)
Phenotype Manifest In
	border follicle cell \| somatic clone (Geisbrecht and Montell, 2004) follicle cell \| somatic clone (Geisbrecht and Montell, 2004)
Detailed Description
	Statement Reference Homozygous follicle cells clones result in border follicle cell migration defects. In large homozygous clones in the follicle epithelium, multinucleate cells are seen. Mutant outer follicle cell clones do not show TUNEL labeling, even 10 days after clone induction. (Geisbrecht and Montell, 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference th^j5C8 is an enhancer of visible phenotype of E2f^Scer\UAS.cNa, Scer\GAL4^Act88F.PD (Morris et al., 2006) th^j5C8 is an enhancer of visible phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003)
Phenotype Manifest In
Enhancer of
Statement Reference th^j5C8 is an enhancer of eye phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003) th^j5C8 is an enhancer of ommatidium phenotype of Hsap\MAPT^{V337M.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Shulman and Feany, 2003) th^j5C8 is an enhancer of wing blade phenotype of E2f^Scer\UAS.cNa, Scer\GAL4^Act88F.PD (Morris et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by th^j5C8. (Shulman and Feany, 2003)
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	12093 y¹ w^*; P{lacW}th^j5C8/TM3, Sb¹
Kyoto	111396 y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}th^j5C8 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹
Notes on Origin
Discoverer	L. and Y. Jan.

Comments
	The P{lacW}th^j5C8 insertion is in the same position as the P{EP}th^EP3308 insertion. (Geisbrecht and Montell, 2004) Transposase induced excision of the P{lacW} is accompanied by reversion of the mutant phenotype. (Hay et al., 1995) Complements: Mbs^j3B4. Complements: Mbs^j7A1. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	l(3)j5C8 (Geisbrecht and Montell, 2004, Spradling et al., 1999, Hay et al., 1995) l(3)j5C8^j5C8 th^j5c8 (Wu et al., 2003, Guan et al., 2007, Wang et al., 2008) th^j5C8 th^jc58 (Bennett and Harvey, 2006) th^l(3)j5C8 (Morris et al., 2006) unnamed (Braun et al., 1997)
Name Synonym
Secondary FlyBase IDs

References ( 19 )
Research paper	Verghese et al., 2012, Cell Death Differ. 19(10): 1664--1676 Hippo signalling controls Dronc activity to regulate organ size in Drosophila. [FBrf0219371] Cooper and Kennison, 2011, PLoS ONE 6(8): e23509 Molecular Genetic Analyses of Polytene Chromosome Region 72A-D in Drosophila melanogaster Reveal a Gene Desert in 72D. [FBrf0214748] Chen et al., 2008, Genome Res. 18(1): 123--136 Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. [FBrf0202125] Wang et al., 2008, Genetics 180(1): 269--281 A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila. [FBrf0207097] Guan et al., 2007, Dev. Biol. 303(1): 16--28 The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. [FBrf0192905] Bennett and Harvey, 2006, Curr. Biol. 16(21): 2101--2110 Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. [FBrf0194636] Morris et al., 2006, PLoS Genet. 2(11): e147 Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. [FBrf0194141] Huang et al., 2005, Cell 122(3): 421--434 The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. [FBrf0187228] Lai et al., 2005, Cell 120(5): 675--685 Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. [FBrf0183777] Geisbrecht and Montell, 2004, Cell 118(1): 111--125 A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration. [FBrf0179220] Shulman and Feany, 2003, Genetics 165(3): 1233--1242 Genetic modifiers of tauopathy in Drosophila. [FBrf0167629] Wu et al., 2003, Cell 114(4): 445--456 hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. [FBrf0161987] Johannes and Preiss, 2002, Mech. Dev. 115(1-2): 3--14 Wing vein formation in Drosophila melanogaster: hairless is involved in the cross-talk between Notch and EGF signaling pathways. [FBrf0149093] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Braun et al., 1997, Genetics 147(2): 623--634 Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap. [FBrf0098749] Hay et al., 1995, Cell 83(7): 1253--1262 Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. [FBrf0085196]
Personal communication to FlyBase	Kennison, 1995.6.21, Complementation data for assorted P{} insertions in the Bloomington collection. Complementation data for assorted P{} insertions in the Bloomington collection. [FBrf0082216] Meister and Braun, 1995.10, lacZ expression patterns for P{} insertions at Bloomington. lacZ expression patterns for P{} insertions at Bloomington. [FBrf0083714] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\thj5C8

Allele Dmel\th^j5C8