FlyBase Allele Report: Dmel\MED17[s2956]

General Information

Symbol

Dmel\MED17^s2956

Species

D. melanogaster

Name

FlyBase ID

FBal0011161

Feature type

allele

Associated gene

Dmel\MED17

Associated Insertion(s)

P{lacW}MED17^s2956

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{lacW}MED17^s2956

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:18,189,217..18,189,217 [-]

(Swaminathan et al., 2010, Boube et al., 2000, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone

(Boube et al., 2000)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygous adults have normal abdominal segmentation.

(Bosveld et al., 2008)

When homozygous somatic clones are induced, none are seen to survive to adulthood.

(Boube et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

skd^pap-1/MED17^s2956 is an enhancer of labial segment phenotype of pb⁵/pb⁴

(Boube et al., 2000)

skd^pap-1/MED17^s2956 is an enhancer of pseudotrachea phenotype of pb⁵/pb⁴

(Boube et al., 2000)

MED17^s2956 is an enhancer of prothoracic leg | distal phenotype of Scr^P, skd^pap-53

(Boube et al., 2000)

MED17^s2956 is an enhancer of sex comb | ectopic phenotype of Scr^P, skd^pap-53

(Boube et al., 2000)

Other

Statement

Reference

MED17^s2956, skd^pap-53 has sex comb | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, skd^pap-53 has prothoracic leg | distal phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-1 has sex comb | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-1 has unguis | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-1 has tarsal segment | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-1 has prothoracic leg | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, Scr^P, skd^pap-53 has sex comb | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, Scr^P, skd^pap-53 has prothoracic leg | distal phenotype

(Boube et al., 2000)

MED17^s2956, Scr^P has sex comb | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, Scr^P has prothoracic leg | distal phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-53 has sex comb | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-53 has unguis | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-53 has tarsal segment | ectopic phenotype

(Boube et al., 2000)

MED17^s2956, pb⁵/pb⁴, skd^pap-53 has prothoracic leg | ectopic phenotype

(Boube et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

MED17^s2956, skd^pap-53 and MED17^s2956, Scr^P flies occasionally exhibit an ectopic distal sex comb on the T1 leg. MED17^s2956, Scr^P, skd^pap-53 flies exhibit a stronger ectopic distal sex comb phenotype than any of the double mutant combinations. The addition of a combination of skd^pap-1 and MED17^s2956 enhances the transformation phenotype seen in the labium of pb⁴/pb⁵ flies. Instead of transformation to antennal structures, a transformation to T1 leg structures (including sex comb teeth and claws) is seen.

(Boube et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10307

w¹¹¹⁸; P{lacW}MED17^s2956/TM3, Sb¹

Notes on Origin

Discoverer

M. Scott.

Comments

Complements: repo⁰³⁷⁰². Complements: l(3)05822⁰⁵⁸²². Complements: 14-3-3ε^j2B10.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

MED17^s2956

(Swaminathan et al., 2010, Christensen et al., 2008.10.20)

Trap80^s2956

(Gutierrez et al., 2003)

dMED17¹

(Bosveld et al., 2008)

dTRAP80¹

(Boube et al., 2000)

l(3)s2956

(Spradling et al., 1999)

l(3)s2956^s2956

(BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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