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General Information
Symbol
Dmel\Med1
Species
D. melanogaster
Name
FlyBase ID
FBal0011292
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C31613045T

Amino acid change:

Q283term | Med-PA; Q283term | Med-PC

Reported amino acid change:

Q283term

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes apparently normal.

Nature of the lesion
Statement
Reference

Amino acid replacement: Q283term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Med1 zygotic mutant embryos occasionally have dorsal defects.

Mutant stage 17 embryos do not show significant defects in the location or formation of the tracheal dorsal trunk branch, dorsal branch 10, spiracular branch 10 or the posterior spiracle.

Embryos lacking maternal and zygotic Med function (Med1/Med25 embryos derived from females with homozygous Med1 germ line clones) show loss of dorsal tissue, expansion of the lateral denticle bands into dorsal regions and severe head defects. The phenotype is partially paternally rescuable. Homozygous clones in the eye are only seen at the margins of the eye, most commonly at the posterior margin, and result in loss of eye tissue.

Late larval early pupal lethality. Reduction in the number of mitosis in the larval brain (FBrf0049822).

Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells and affects chromosome condensation.

imaginal discs missing weak effect on mitotic chromosome condensation Homozygous larvae contain rudimentary imaginal discs, but disc primordia do not grow during larval development; testes and ovaries smaller than normal and cell number in central nervous system reduced. Mutant gonads do not survive metamorphosis when implanted into wild-type larvae. Homozygous cuticular clones appear to develop normally, but with reduced frequency and size compared to control clones. Mutant larvae support growth of implanted wild-type discs. Normal gene product postulated to be required for cell proliferation; survival of somatic epidermal clones attributed to perdurance. Larval ganglion mitoses exhibit weak effect on chromosome condensation as well as chromosome breakage (Gatti and Baker, 1989);

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference

Med1 has lethal | recessive phenotype, non-enhanceable by lilliunspecified

Suppressor of
Statement
Reference

Med[+]/Med1 is a suppressor of visible phenotype of Scer\GAL4A9, gbbUAS.cKa

Med[+]/Med1 is a suppressor of visible phenotype of Scer\GAL4A9, dppUAS.cHa

Med[+]/Med1 is a suppressor of visible phenotype of tkvSC143

Med[+]/Med1 is a suppressor of visible phenotype of Scer\GAL4en-e16E, saxQ263D.UAS.cDa

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

Med1 is an enhancer of phenotype of dpphr4

Suppressor of
Statement
Reference

Med[+]/Med1 is a suppressor of wing vein phenotype of Scer\GAL4A9, gbbUAS.cKa

Med[+]/Med1 is a suppressor of wing phenotype of Scer\GAL4A9, dppUAS.cHa

Med[+]/Med1 is a suppressor of wing phenotype of tkvSC143

Med[+]/Med1 is a suppressor of wing | posterior phenotype of Scer\GAL4en-e16E, saxQ263D.UAS.cDa

Med[+]/Med1 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4en-e16E, saxQ263D.UAS.cDa

Additional Comments
Genetic Interactions
Statement
Reference

Slightly suppresses the wing phenotype produced by tkvSC143. Shows a dominant maternal effect interaction with dpp; when Med1/+ females are crossed to dpphr27/+ males, all progeny carrying dpphr27 die. This lethality is rescued by MedUbi-p63E.PD also partly by MadUbi-p63E.T:Hsap\MYC.

Maternal lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (16)