C31613045T
Q283term | Med-PA; Q283term | Med-PC
Q283term
Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.
Polytene chromosomes apparently normal.
Amino acid replacement: Q283term.
Med1 zygotic mutant embryos occasionally have dorsal defects.
Mutant stage 17 embryos do not show significant defects in the location or formation of the tracheal dorsal trunk branch, dorsal branch 10, spiracular branch 10 or the posterior spiracle.
Embryos lacking maternal and zygotic Med function (Med1/Med25 embryos derived from females with homozygous Med1 germ line clones) show loss of dorsal tissue, expansion of the lateral denticle bands into dorsal regions and severe head defects. The phenotype is partially paternally rescuable. Homozygous clones in the eye are only seen at the margins of the eye, most commonly at the posterior margin, and result in loss of eye tissue.
Late larval early pupal lethality. Reduction in the number of mitosis in the larval brain (FBrf0049822).
Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells and affects chromosome condensation.
imaginal discs missing weak effect on mitotic chromosome condensation Homozygous larvae contain rudimentary imaginal discs, but disc primordia do not grow during larval development; testes and ovaries smaller than normal and cell number in central nervous system reduced. Mutant gonads do not survive metamorphosis when implanted into wild-type larvae. Homozygous cuticular clones appear to develop normally, but with reduced frequency and size compared to control clones. Mutant larvae support growth of implanted wild-type discs. Normal gene product postulated to be required for cell proliferation; survival of somatic epidermal clones attributed to perdurance. Larval ganglion mitoses exhibit weak effect on chromosome condensation as well as chromosome breakage (Gatti and Baker, 1989);
Med1 has lethal | recessive phenotype, non-enhanceable by lilliunspecified
Med[+]/Med1 is a suppressor of visible phenotype of Scer\GAL4A9, gbbUAS.cKa
Med[+]/Med1 is a suppressor of visible phenotype of Scer\GAL4A9, dppUAS.cHa
Med[+]/Med1 is a suppressor of visible phenotype of Scer\GAL4en-e16E, saxQ263D.UAS.cDa
Med1, dpphr27/dpp[+] has lethal | dominant | maternal effect phenotype
Med[+]/Med1 is a suppressor of wing vein phenotype of Scer\GAL4A9, gbbUAS.cKa
Med[+]/Med1 is a suppressor of wing phenotype of Scer\GAL4A9, dppUAS.cHa
Med[+]/Med1 is a suppressor of wing | posterior phenotype of Scer\GAL4en-e16E, saxQ263D.UAS.cDa
Med[+]/Med1 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4en-e16E, saxQ263D.UAS.cDa
Slightly suppresses the wing phenotype produced by tkvSC143. Shows a dominant maternal effect interaction with dpp; when Med1/+ females are crossed to dpphr27/+ males, all progeny carrying dpphr27 die. This lethality is rescued by MedUbi-p63E.PD also partly by MadUbi-p63E.T:Hsap\MYC.
Maternal lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells.