Med1 zygotic mutant embryos occasionally have dorsal defects.
Mutant stage 17 embryos do not show significant defects in the location or formation of the tracheal dorsal trunk branch, dorsal branch 10, spiracular branch 10 or the posterior spiracle.
Embryos lacking maternal and zygotic Med function (Med1/Med25 embryos derived from females with homozygous Med1 germ line clones) show loss of dorsal tissue, expansion of the lateral denticle bands into dorsal regions and severe head defects. The phenotype is partially paternally rescuable. Homozygous clones in the eye are only seen at the margins of the eye, most commonly at the posterior margin, and result in loss of eye tissue.
Late larval early pupal lethality. Reduction in the number of mitosis in the larval brain (FBrf0049822).
Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells and affects chromosome condensation.
imaginal discs missing weak effect on mitotic chromosome condensation Homozygous larvae contain rudimentary imaginal discs, but disc primordia do not grow during larval development; testes and ovaries smaller than normal and cell number in central nervous system reduced. Mutant gonads do not survive metamorphosis when implanted into wild-type larvae. Homozygous cuticular clones appear to develop normally, but with reduced frequency and size compared to control clones. Mutant larvae support growth of implanted wild-type discs. Normal gene product postulated to be required for cell proliferation; survival of somatic epidermal clones attributed to perdurance. Larval ganglion mitoses exhibit weak effect on chromosome condensation as well as chromosome breakage (Gatti and Baker, 1989);