Allele Dmel\pan¹³

General Information
Symbol	Dmel\pan¹³	Species	D. melanogaster
Name		FlyBase ID	FBal0011368
Feature type	allele	Associated gene	Dmel\pan
Also Known As	l(4)13, 13

Allele class	loss of function allele
Mutagen	X ray
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Brunner et al., 1997)
Mutagen	X ray (Hochman et al., 1964, Hochman, 1971, Hochman, 1974, Hochman, 1976)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion into the promoter region. (van de Wetering et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| recessive (Hochman, 1974, Hochman, 1971, Hochman, 1976) lethal \| recessive (Locke and Hanna, 1996, Hochman et al., 1964)
Phenotype Manifest In
	embryonic/larval cuticle \| segment polarity expression pattern (Brunner et al., 1997) embryonic/larval epidermis \| segment polarity expression pattern (Brunner et al., 1997) photoreceptor (Boutros et al., 1998)
Detailed Description
	Statement Reference Eyes of flies transheterozygous for pan¹³/pan^ER1 and raised at non-permissive temperature show normal polarity although some ommatidia contain extra photoreceptors. (Boutros et al., 1998) Homozygotes show a segment polarity phenotype in which the larval epidermis forms a lawn of ventral denticles and lacks naked cuticle between the segmental denticle belts. Individual denticles retain their correct polarity. The lawn of denticles phenotype is not suppressed when arm^{Δ.Scer\UAS.T:Ivir\HA1} is expressed using Scer\GAL4^hs.PB, indicating that pan acts downstream of arm. (Brunner et al., 1997)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference pan¹³ is a suppressor of eye photoreceptor cell phenotype of Apc^Q8 (Ahmed et al., 1998)
NOT Suppressor of
Statement Reference pan¹³ is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev (Fanto et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference Some photoreceptors are rescued from death in Apc^Q8 homozygotes carrying one copy of pan¹³. (Ahmed et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	pan^ciD (Brunner et al., 1997) pan^ER1 (Brunner et al., 1997)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Second insertion of ci^D. (van de Wetering et al., 1997)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	13 (Hochman, 1971, Hochman et al., 1964) ci^102ABb-2 l(4)13 (Locke and Hanna, 1996, Tearle and Nusslein-Volhard, 1987, Hochman, 1976, Hochman, 1974, ) pan¹³
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Fanto et al., 2000, Curr. Biol. 10(16): 979--988 Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. [FBrf0129802] Ahmed et al., 1998, Cell 93(7): 1171--1182 Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. [FBrf0102882] Boutros et al., 1998, Cell 94(1): 109--118 Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. [FBrf0103240] Brunner et al., 1997, Nature 385(6619): 829--833 pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. [FBrf0092477] van de Wetering et al., 1997, Cell 88(6): 789--799 Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. [FBrf0093264] Locke and Hanna, 1996, Dev. Genet. 19(4): 340--349 engrailed gene dosage determines whether certain recessive cubitus interruptus alleles exhibit dominance of the adult wing phenotype in Drosophila. [FBrf0092613] Hochman, 1974, Cold Spring Harbor Symp. Quant. Biol. 38: 581--589 Analysis of a whole chromosome in Drosophila. [FBrf0026003] Hochman, 1971, Genetics 67: 235--252 Analysis of chromosome 4 in Drosophila melanogaster. [FBrf0022724] Hochman et al., 1964, Genetica 35: 109--126 Analysis of chromosome 4 in Drosophila melanogaster. [FBrf0016176]
Supplementary material	Fanto, 2000, Curr. Biol. 10(16): Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. [FBrf0131040]
Review	Hochman, 1976, Ashburner, Novitski, 1976 b: 903--928 The fourth chromosome of Drosophila melanogaster. [FBrf0028344]
Abstract	Schweizer and Basler, 1998, A. Dros. Res. Conf. 39: 152B CiD encodes a Pangolin/Cubitus interruptus fusion protein coupling the Hedgehog and Wingless signaling pathways. [FBrf0101190] Von Ohlen and Hooper, 1998, A. Dros. Res. Conf. 39: 175A The ci^D mutation produces a Pangolin/Ci fusion protein whose activity is regulated by wingless signaling. [FBrf0101212]
Stock list	Tearle and Nusslein-Volhard, 1987, D. I. S. 66: 209--269 Tubingen mutants and stock list. [FBrf0045941]

Allele Dmel\pan13

Allele Dmel\pan¹³