FlyBase Allele Report: Dmel\pigeon[P1]

General Information

Symbol

Dmel\pigeon^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0011653

Feature type

allele

Associated gene

Dmel\pigeon

Associated Insertion(s)

P{lacW}pigeon^P1

Carried in Construct

Also Known As

lio¹

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bolwig et al., 1995)

Mutagen

P-element activity

(Dura et al., 1993)

PM hybrid dysgenesis

(Tully et al., 1992)

Progenitor genotype

Associated Insertion(s)

P{lacW}pigeon^P1

Cytology

Description

The P{etau-lacZ}drl^P3.765 insertion in drl^P3.765 is inserted at the same nucleotide as the P{lacW}pigeon^P1 insertion.

(Moreau-Fauvarque et al., 1998)

P{lacW} is inserted approximately 800bp 3' to the pigeon transcription unit, in an opposite orientation. The insertion site is 6bp distal to that of P{etau-lacZ}drl^P3.765 (also transcribed in the opposite direction to the pigeon and drl transcription units).

(Bolwig et al., 1995)

Insertion of P{lacW} between pigeon and drl.

(Dura et al., 1995)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:19,190,341..19,190,341 [+]

(Bolwig et al., 2002, Tully, 1999.7.2, Preat, 1998, Simon et al., 1998, Bolwig et al., 1995, Dura et al., 1995, Dura et al., 1993, Tully et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning

(Bolwig et al., 1995, Dura et al., 1993, Tully et al., 1992)

abnormal memory

(Bolwig et al., 1995, Dura et al., 1993)

abnormal memory | progressive

(Tamura et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant animals show decreased 1 hour memory that is further reduced by aging.

(Tamura et al., 2003)

After presentation of electric shock with a first odour, P{lacW}pigeon^P1 flies show a wild-type response to a second, different odour.

(Preat, 1998)

Mutant flies show some pupal lethality, indicating a developmental defect as well as a learning and memory defect for the P{lacW}pigeon^P1 chromosome.

(Simon et al., 1998)

Shows mutant learning and 3 hour retention scores.

(Bolwig et al., 1995)

Sensory and motor systems (olfactory acuity and shock reactivity) required for the classical conditioning experiments are normal indicating that the mutation disrupts learning/memory specifically.

(Dura et al., 1993)

Flies exhibit defective initial learning levels, thereafter mutant memory decays as wild type.

(Tully et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

pigeon[+]/pigeon^P1 is an enhancer of eye phenotype of Dref^UAS.cSa

(Ida et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

pigeon^P1 is not rescued by pigeon^hs.PB

(Bolwig et al., 2002)

Comments

Mutant learning and memory phenotypes can be rescued by pigeon^hs.PB. Gross anatomy of mushroom bodies and central complex is normal in pigeon^P1 mutants. FlyBase curator comment: In a subsequent publication (Bolwig et al., 2002, Neuron 34: 667) the authors describe how repeat of these rescue experiments failed to reproduce the rescue of the adult learning defect of pigeon^P1 by FBtp0006269.

(Bolwig et al., 1995)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Isolation: in a screen for three-hour memory deficits after classical conditioning of an olfactory avoidance response.

(Dura et al., 1993)

Comments

P{lacW}pigeon^P1 is inserted 800 bp downstream of the pigeon transcription unit, perhaps in the 5'UTR of drl. In fact, the P{etau-lacZ} in drl^P3.765, is inserted 6 bp away from the pigeon^P1 allele. The P{lacW} insertion in the pigeon^P1 mutant could therefore be causing an additional drl phenotype.

(Tully, 1999.7.2)

In contradiction to the result published in FBrf0083785, the pigeon transcript in adult heads is not affected in size or abundance in pigeon^P1;drl^P1 mutants.

(Moreau-Fauvarque et al., 2002)

The pigeon^P1 mutation disrupts expression of the pigeon transcript.

(Bolwig et al., 2002)

Reversion assay reveals the P{lacW} insertion is responsible for the mutant phenotype.

(Dura et al., 1993)

Wild type P-element revertants have been generated.

(Tully et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

lio¹

(van Swinderen, 2007, Tamura et al., 2003, Moreau-Fauvarque et al., 2002, Simon et al., 1998, Bolwig et al., 1995, Bolwig et al., 1995, Dura et al., 1995, Dura et al., 1993)

lio^P1

(Bolwig et al., 2002)

pigeon^P1

pigeonP1

(Ida et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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