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General Information
Symbol
Dmel\lt1
Species
D. melanogaster
Name
FlyBase ID
FBal0011677
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
lt
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of approximately 200bp.

Carried on aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

lt1 mutant third instar larvae do not show accumulations of acidic organelles (marked by Lysotracker) in the somatic muscles.

Mutant males have a shortened adult life span compared to controls, with a mean life span of 24.92 days at 25o.

Eye colour: uniform orange.

Disrupt ommochrome and pteridine synthesis.

Eye colour: orange, with lthdS1. Malpighian tubule colour: reduced. Homozygous larvae have a low level of pigmentation in the Malpighian tubules, with a uniform distribution of small pigment granules.

The amount of such pigment in Malpighian tubules increases with maternal age for both lt1/+ and lt1/lt1 parental females.

Drosopterins drastically reduced; no maternal effect in homozygous germ-line clones on eye pigmentation.

Malpighian tubule colour: colourless in lt1 offspring of lt1 mothers. Malpighian tubule colour: some colour in lt1 offspring of lt1/+ mothers. The quantity of yellow pigment, composed primarily of riboflavin, in Malpighian tubes exhibits parallel maternal effects in larvae, pupae and adults.

Eye color autonomous in mutant optic discs transplanted into wild-type hosts.

Eye colour: slightly lighter than lt1 alone, with st1. Eye colour: clear yellow, pinkish in old flies, with bw1.

Eye colour: yellowish pink; lighter at high temperature, darker at low. Ocellus colour: colourless.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Su(var)2-1+ :, /lt1/lt11 has eye color defective phenotype, enhanceable by Su(var)2-1[+]/Su(var)2-1[+]/Su(var)2-11/Su(var)2-1v9

lt1/lt11 has eye color defective phenotype, enhanceable by Su(var)205[+]/E(Pc)[+]/Su(var)2051/E(Pc)unspecified

lt1/lt11 has eye color defective phenotype, enhanceable by Su(var)208[+]/Su(var)208unspecified/E(Pc)[+]/E(Pc)unspecified

lt1/lt11 has eye color defective phenotype, enhanceable by Su(var)208[+]/Su(var)208unspecified/Su(var)205[+]/Su(var)2051

lt1/lt11 has eye color defective phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)2-11/Su(var)208unspecified

lt1/lt11 has eye color defective phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)208unspecified/Su(var)2-1v9

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

Su(var)2-1+ :, /lt1/lt11 has pigment cell phenotype, enhanceable by Su(var)2-1[+]/Su(var)2-1[+]/Su(var)2-11/Su(var)2-1v9

lt1/lt11 has pigment cell phenotype, enhanceable by Su(var)2-11

lt1/lt11 has pigment cell phenotype, enhanceable by Su(var)2-1v9

lt1/lt11 has pigment cell phenotype, enhanceable by Su(var)205[+]/E(Pc)[+]/Su(var)2051/E(Pc)unspecified

lt1/lt11 has pigment cell phenotype, enhanceable by Su(var)208[+]/Su(var)208unspecified/E(Pc)[+]/E(Pc)unspecified

lt1/lt11 has pigment cell phenotype, enhanceable by Su(var)208[+]/Su(var)208unspecified/Su(var)205[+]/Su(var)2051

lt1/lt11 has pigment cell phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)2-11/Su(var)208unspecified

lt1/lt11 has pigment cell phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)208unspecified/Su(var)2-1v9

NOT suppressed by
Statement
Reference

lt1 has phenotype, non-suppressible by su(Hw)2

Other
Additional Comments
Genetic Interactions
Statement
Reference

The variegation of lt seen in lt1/T(2;3)ltX13 flies is enhanced by Df(3R)Ace-HD1.

Eye pigmentation in lt11/lt1 flies is reduced if the flies are also carrying E(Pc)unspecified/Su(var)2051, E(Pc)unspecified/Su(var)208unspecified, Su(var)208unspecified/Su(var)2051, Su(var)208unspecified/Su(var)2-11, Su(var)2-1v9/Su(var)2-11 or Su(var)2-1v9/Su(var)208unspecified. XY lt11/lt1; Su(var)2-1v9/Su(var)2-11 males have reduced viability, which is restored in XO males. lt11/lt1; Su(var)2-1v9/Su(var)2051 flies have reduced viability. Viability is partially restored in XO males. lt11/lt1; Su(var)208unspecified/Su(var)2051 flies have reduced viability. Viability is restored in XO males.

Eye colour: lt1 g53d double mutants show a marked reduction in eye pigment. Eye colour: lt1/lt11 g53d double mutants show a reduction in red eye pigment compared to either lt1/lt11 or g53d single mutants.

Lethal focus of the lt car lethal interaction as measured in car1/+; lt1/lt1, car1/0; lt1/lt1 gynandromorphs is in ventral nervous tissue.

The time of death of lt1 car1 double homozygotes varies from the third larval instar to late pupa, depending on the number of normal alleles of either gene carried by the mother.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Rescued by
Not rescued by

lt1 is not rescued by lttDe

Comments
Images (2)
Stocks (21)
Notes on Origin
Discoverer

Bridges, 8th April 1924.

Bridges, 1924.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (26)