Allele Dmel\lt¹¹

General Information
Symbol	Dmel\lt¹¹	Species	D. melanogaster
Name		FlyBase ID	FBal0011687
Feature type	allele	Associated gene	Dmel\lt
Also Known As	lt^40-12, EMS40-12

Allele class	amorphic allele - genetic evidence, hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Wakimoto, 2008.11.19) hypomorphic allele - genetic evidence (Wakimoto and Hearn, 1990)
Mutagen	ethyl methanesulfonate (Hilliker, 1976, Wakimoto and Hearn, 1990)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective \| recessive (Clegg et al., 1998, Warner et al., 1998) lethal (Devlin et al., 1990, ) lethal \| dominant (Wakimoto and Hearn, 1990)
Phenotype Manifest In
	pigment cell (Clegg et al., 1998, Warner et al., 1998)
Detailed Description
	Statement Reference lt^hdS1A/lt¹¹ flies have 60% wild-type viability. (Devlin et al., 1990) Reduced eye and Malpighian tubule cell pigmentation, variable crumpled wings and missing bristles. Moderate position effect variegation is seen with lt rearrangements. (Wakimoto and Hearn, 1990) Hemizygotes die at late pupal stages. (Hilliker, 1976)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Su(var)2-1[+]:, /lt¹/lt¹¹ has eye color defective phenotype, enhanceable by Su(var)2-1[+]/Su(var)2-1[+]/Su(var)2-1¹/Su(var)2-1^v9 (Clegg et al., 1998) lt¹/lt¹¹ has eye color defective phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)2-1¹/Su(var)208^unspecified (Clegg et al., 1998) lt¹/lt¹¹ has eye color defective phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)208^unspecified/Su(var)2-1^v9 (Clegg et al., 1998) lt¹/lt¹¹ has eye color defective phenotype, enhanceable by Su(var)2-1¹ (Clegg et al., 1998) lt¹/lt¹¹ has eye color defective phenotype, enhanceable by Su(var)2-1^v9 (Clegg et al., 1998) lt¹/lt¹¹ has eye color defective phenotype, enhanceable by Su(var)205[+]/E(Pc)[+]/Su(var)205¹/E(Pc)^unspecified (Clegg et al., 1998) lt¹/lt¹¹ has eye color defective phenotype, enhanceable by Su(var)208[+]/Su(var)208^unspecified/E(Pc)[+]/E(Pc)^unspecified (Clegg et al., 1998) lt¹/lt¹¹ has eye color defective phenotype, enhanceable by Su(var)208[+]/Su(var)208^unspecified/Su(var)205[+]/Su(var)205¹ (Clegg et al., 1998) lt¹/lt¹¹ has lethal \| partially phenotype, enhanceable by Su(var)208[+]/Su(var)208^unspecified/Su(var)205[+]/Su(var)205¹ (Clegg et al., 1998) lt¹¹ has eye color defective \| recessive phenotype, enhanceable by Su(var)2-1¹/Su(var)2-1^v9 (Clegg et al., 1998) lt¹¹ has eye color defective \| recessive phenotype, enhanceable by Su(var)2-1¹/Su(var)208^unspecified (Clegg et al., 1998) lt¹¹ has eye color defective \| recessive phenotype, enhanceable by Su(var)205¹/E(Pc)^unspecified (Clegg et al., 1998) lt¹¹ has eye color defective \| recessive phenotype, enhanceable by Su(var)208^unspecified/E(Pc)^unspecified (Clegg et al., 1998) lt¹¹ has eye color defective \| recessive phenotype, enhanceable by Su(var)208^unspecified/Su(var)2-1^v9 (Clegg et al., 1998) lt¹¹ has eye color defective \| recessive phenotype, enhanceable by Su(var)208^unspecified/Su(var)205¹ (Clegg et al., 1998) lt¹¹ has eye color defective phenotype, enhanceable by Su(var)208^unspecified/E(Pc)^unspecified (Clegg et al., 1998) lt¹¹ has eye color defective phenotype, enhanceable by Su(var)208^unspecified/Su(var)2-1^v9 (Clegg et al., 1998) lt¹¹ has lethal \| recessive \| partially phenotype, enhanceable by Su(var)208^unspecified/Su(var)205¹ (Clegg et al., 1998)
Other
Statement Reference car¹, lt¹/lt¹¹ has lethal \| recessive phenotype (Warner et al., 1998) car¹, lt¹/lt¹¹ has lethal phenotype (Warner et al., 1998) dor¹, lt¹/lt¹¹ has lethal \| recessive phenotype (Warner et al., 1998) dor¹, lt¹/lt¹¹ has lethal phenotype (Warner et al., 1998) Dp(2;Y)G, E(Pc)^unspecified, Su(var)208^unspecified, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) Dp(2;Y)G, Su(var)2-1^v9, Su(var)208^unspecified, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)2-1¹, lt¹¹ has eye color defective phenotype (Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)2-1¹, lt¹¹ has viable phenotype (Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)2-1^v9, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)2-1^v9, lt¹¹ has viable phenotype (Clegg et al., 1998, Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)208^unspecified, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)208^unspecified, lt¹¹ has viable \| reduced phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(lt^v)335³³⁵, Su(var)2-1^v9, lt¹¹ has viable \| reduced phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(lt^v)335³³⁵, Su(var)208^unspecified, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(lt^v)335³³⁵, Su(var)208^unspecified, lt¹¹ has viable \| reduced phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(Pc)^unspecified, E(lt^v)319³¹⁹, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(Pc)^unspecified, E(lt^v)319³¹⁹, lt¹¹ has viable phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(Pc)^unspecified, E(lt^v)335³³⁵, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(Pc)^unspecified, E(lt^v)335³³⁵, lt¹¹ has viable phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(Pc)^unspecified, Su(var)208^unspecified, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998) g^53d, lt¹/lt¹¹ has eye color defective \| recessive phenotype (Warner et al., 1998) g^53d, lt¹¹ has eye color defective \| recessive phenotype (Warner et al., 1998) Su(var)2-1¹/Su(var)2-1^v9, lt¹¹ has lethal \| male \| partially \| recessive phenotype (Clegg et al., 1998) Su(var)2-1^v9, Su(var)205¹, lt¹/lt¹¹ has lethal \| recessive \| partially phenotype (Clegg et al., 1998, Clegg et al., 1998) Su(var)2-1^v9, Su(var)205¹, lt¹¹ has lethal \| recessive \| partially phenotype (Clegg et al., 1998) Su(var)2-1^v9, Su(var)208^unspecified, lt¹¹ has eye color defective phenotype (Clegg et al., 1998, Clegg et al., 1998)
Phenotype Manifest In
Enhanced by
Statement Reference Su(var)2-1[+]:, /lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1[+]/Su(var)2-1[+]/Su(var)2-1¹/Su(var)2-1^v9 (Clegg et al., 1998) lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)2-1¹/Su(var)208^unspecified (Clegg et al., 1998) lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1[+]/Su(var)208[+]/Su(var)208^unspecified/Su(var)2-1^v9 (Clegg et al., 1998) lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1¹ (Clegg et al., 1998) lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1^v9 (Clegg et al., 1998) lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)205[+]/E(Pc)[+]/Su(var)205¹/E(Pc)^unspecified (Clegg et al., 1998) lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)208[+]/Su(var)208^unspecified/E(Pc)[+]/E(Pc)^unspecified (Clegg et al., 1998) lt¹/lt¹¹ has pigment cell phenotype, enhanceable by Su(var)208[+]/Su(var)208^unspecified/Su(var)205[+]/Su(var)205¹ (Clegg et al., 1998) lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1¹/Su(var)2-1^v9 (Clegg et al., 1998) lt¹¹ has pigment cell phenotype, enhanceable by Su(var)2-1¹/Su(var)208^unspecified (Clegg et al., 1998) lt¹¹ has pigment cell phenotype, enhanceable by Su(var)205¹/E(Pc)^unspecified (Clegg et al., 1998) lt¹¹ has pigment cell phenotype, enhanceable by Su(var)208^unspecified/E(Pc)^unspecified (Clegg et al., 1998) lt¹¹ has pigment cell phenotype, enhanceable by Su(var)208^unspecified/Su(var)2-1^v9 (Clegg et al., 1998) lt¹¹ has pigment cell phenotype, enhanceable by Su(var)208^unspecified/Su(var)205¹ (Clegg et al., 1998)
Other
Statement Reference Dp(2;Y)G, E(Pc)^unspecified, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) Dp(2;Y)G, Su(var)2-1^v9, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)2-1¹, lt¹¹ has pigment cell phenotype (Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)2-1^v9, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998) E(lt^v)319³¹⁹, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(lt^v)335³³⁵, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(Pc)^unspecified, E(lt^v)319³¹⁹, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(Pc)^unspecified, E(lt^v)335³³⁵, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998, Clegg et al., 1998) E(Pc)^unspecified, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998) g^53d, lt¹/lt¹¹ has pigment cell phenotype (Warner et al., 1998) g^53d, lt¹¹ has pigment cell phenotype (Warner et al., 1998) Su(var)2-1^v9, Su(var)208^unspecified, lt¹¹ has pigment cell phenotype (Clegg et al., 1998, Clegg et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference Eye pigmentation in lt¹¹/lt¹ flies is reduced if the flies are also carrying E(Pc)^unspecified/Su(var)205¹, E(Pc)^unspecified/Su(var)208^unspecified, Su(var)208^unspecified/Su(var)205¹, Su(var)208^unspecified/Su(var)2-1¹, Su(var)2-1^v9/Su(var)2-1¹ or Su(var)2-1^v9/Su(var)208^unspecified. Eye pigmentation in lt¹¹/+ flies that are also carrying E(Pc)^unspecified/Su(var)208^unspecified or Su(var)2-1^v9/Su(var)208^unspecified is reduced. Pigmentation is restored to wild-type levels in these flies by Dp(2;Y)G. XY lt¹¹/lt¹; Su(var)2-1^v9/Su(var)2-1¹ males have reduced viability, which is restored in XO males. lt¹¹/lt¹; Su(var)2-1^v9/Su(var)205¹ flies have reduced viability. Viability is partially restored in XO males. lt¹¹/lt¹; Su(var)208^unspecified/Su(var)205¹ flies have reduced viability. Viability is restored in XO males. Eye pigmentation is reduced and viability is essentially wild-type in lt¹¹/+ flies that are also carrying E(Pc)^unspecified and E(lt^v)319³¹⁹, E(Pc)^unspecified and E(lt^v)335³³⁵ or Su(var)2-1^v9 and E(lt^v)319³¹⁹. Eye pigmentation and viability is reduced in lt¹¹/+ flies that are also carrying Su(var)208^unspecified and E(lt^v)319³¹⁹ or Su(var)208^unspecified and E(lt^v)335³³⁵. Eye pigmentation is nearly wild-type and viability is reduced in lt¹¹/+ flies that are also carrying Su(var)2-1^v9 and E(lt^v)335³³⁵. (Clegg et al., 1998) Eye colour: lt¹/lt¹¹ g^53d double mutants show a reduction in red eye pigment compared to either lt¹/lt¹¹ or g^53d single mutants. (Warner et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Df(2L)C'/lt¹¹ is rescued by lt^{+tCH321-64G01} (Venken et al., 2009)
Not rescued by	Df(2L)C'/lt¹¹ is not rescued by lt^tCH321-05E14 (Venken et al., 2009) Df(2L)C'/lt¹¹ is not rescued by lt^tCH321-16H04 (Venken et al., 2009)
Comments
Stocks ( 1 )
Bloomington	26262 lt¹¹/In(2LR)Gla, wg^Gla-1 Bc¹
Notes on Origin
Discoverer	Hilliker.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	40-12 (Howe et al., 1995) EMS40-12 (Devlin et al., 1990, Hilliker, 1976) l(2)40Fb^40-12 (Wakimoto and Hearn, 1990) l(2)EMS40-12 lt¹¹ (Wakimoto, 2008.11.19, Venken et al., 2009) lt^40-12 (Clegg et al., 1998, Warner et al., 1998)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Clegg et al., 1998, Genome 41(4): 495--503 Suppressors of position-effect variegation in Drosophila melanogaster affect expression of the heterochromatic gene light in the absence of a chromosome rearrangement. [FBrf0105209] Warner et al., 1998, Genome 41(2): 236--243 The light gene of Drosophila melanogaster encodes a homologue of VPS41, a yeast gene involved in cellular-protein trafficking. [FBrf0103059] Howe et al., 1995, Genetics 140(3): 1033--1045 Cis-effects of heterochromatin on heterochromatic and euchromatic gene activity in Drosophila melanogaster. [FBrf0083203] Devlin et al., 1990, Genetics 125: 129--140 The organization and expression of the light gene, a heterochromatic gene of Drosophila melanogaster. [FBrf0051922] Wakimoto and Hearn, 1990, Genetics 125: 141--154 The effects of chromosome rearrangements on the expression of heterochromatic genes in chromosome 2L of Drosophila melanogaster. [FBrf0051926] Hilliker, 1976, Genetics 83: 765--782 Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: Deficiency mapping of EMS-induced lethal complementation groups. [FBrf0028786]
Supplementary material	Venken et al., 2009, Nat. Methods 6(6): Supplementary figures and text. [FBrf0210704]
Personal communication to FlyBase	Wakimoto, 2008.11.19, Info on 2L het Dfs and alleles. Info on 2L het Dfs and alleles. [FBrf0206282]

Allele Dmel\lt11

Allele Dmel\lt¹¹