Allele Dmel\lz^s

General Information
Symbol	Dmel\lz^s	Species	D. melanogaster
Name	spectacled	FlyBase ID	FBal0011830
Feature type	allele	Associated gene	Dmel\lz

Allele class
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	X ray (Green and Green, 1956, Crew et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deletion of 3957bp in the upstream region and exon I of lz. (Jackson Behan et al., 2005) Mutation of cistron B. (Crew et al., 1997)
Carried on aberration	FM1 (FlyBase Curators, 2006-, Lindsley and Zimm, 1992, Bloomington Drosophila Stock Center, 1998.5.16) FM1-B⁺l (FlyBase Curators, 2006-) FM7b (FlyBase Curators, 2006-, Lindsley and Zimm, 1992) M9 (FlyBase Curators, 2006-)
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective \| recessive (Green and Green, 1956) increased cell death (Siddall et al., 2003) visible (Siddall et al., 2003, Crew et al., 1997) visible \| recessive (Batterham et al., 1996, Green and Green, 1956)
Phenotype Manifest In
	cone cell (Crew et al., 1997) eye (Batterham et al., 1996, Green and Green, 1956, Siddall et al., 2003) eye disc (Siddall et al., 2003) lamina (Batterham et al., 1996) lens (Batterham et al., 1996) lobula (Batterham et al., 1996) lobula plate (Batterham et al., 1996) medulla (Batterham et al., 1996) ommatidium (Batterham et al., 1996) ovary (Green and Green, 1956) photoreceptor cell R1 (Crew et al., 1997) photoreceptor cell R6 (Crew et al., 1997) pigment cell (Batterham et al., 1996, Green and Green, 1956) retina (Batterham et al., 1996) sensillum basiconicum of antennal segment 3 (Stocker et al., 1993) sensillum trichodeum of antennal segment 3 (Stocker et al., 1993) spermathecum (Green and Green, 1956) third segment of antenna (Stocker et al., 1993) unguis (Green and Green, 1956)
Detailed Description
	Statement Reference lz^s adults have a "spectacle" eye phenotype. Ectopic cell death is seen in third larval instar eye discs. (Siddall et al., 2003) 15% of photoreceptor cell clusters are abnormal, cells R1 and R6 are not recruited properly. Uniform sheet of unorganised cone cells is found. The periphery of the retina contains cells in loosely organised clusters including cone as well as primary and secondary pigment cells, the darker pigment produces the 'spectacle' phenotype. The fenestrated membrane at the base of the retina is shredded. (Crew et al., 1997) Homozygotes have a total lack of ommatidial structure in the eye. Pigment is dispersed as a ring around the edge of the eye ("spectacle" phenotype). The entire retina and the underlying lamina are defective. Few, if any, lenses form. The arrangement of the pigment cells is completely deranged, resulting in the complete loss of the fenestrated membrane. Numerous photoreceptor cells are found displacing the lamina. The optic ganglia of the medulla, lobula and lobula plate are also perturbed. (Batterham et al., 1996) The antennal funiculus is reduced in size in hemizygous males. All large and small basiconic sensilla on the antennal funiculus are missing, and the number of trichoid sensilla on the antennal funiculus is reduced. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic sensilla on the antennal funiculus is increased and the density of the trichoid sensilla on the antennal funiculus is decreased compared to wild-type. (Stocker et al., 1993) Eyes are greatly reduced in size and have a smooth surface in homozygous flies. Red eye pigment is sparse and confined primarily to the margin of the eye. Tarsal claws are vestigial. The spermathecae and pars ovariae are absent in homozygous females. (Green and Green, 1956) Eye size reduced, narrower than normal; no true facets; whole eye has glossy surface; color yellow-brown with darker rim, creamy in combination with v. Tarsal claws vestigial. Homozygous females lack spermathecae and parovaria and are sterile. lz^s/+ females tend to have abnormal parovaria (Anderson, 1945). RK1. spectacle; tarsal structures reduced or absent; spermathecae absent; parovaria absent female-sterile
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement Reference lz^s has phenotype, non-suppressible by su(Hw)² (Lindsley and Grell, 1968)
Suppressor of
Statement Reference lz^s is a suppressor of embryonic/larval lymph gland phenotype of Bc¹ (Rizki and Rizki, 1981) lz^s is a suppressor of hemocyte phenotype of Bc¹ (Rizki and Rizki, 1981) lz^s is a suppressor of hemolymph phenotype of Bc¹ (Rizki and Rizki, 1981)
Additional Comments
Genetic Interactions
Statement Reference Causes suppression of paracrystalline inclusions in hemocytes of Bc¹ larvae. Also suppresses heat-induced blackening of crystal cells in the Bc¹ hemolymph and lymph glands. (Rizki and Rizki, 1981)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	lz^50e (Batterham et al., 1996) lz^77a7 (Batterham et al., 1996)
Fails to complement	lz³⁶ (Batterham et al., 1996) lz^48f (Batterham et al., 1996) lz^g (Batterham et al., 1996) lz^L (Batterham et al., 1996) lz^mr2 (Batterham et al., 1996) lz^pm1 (Batterham et al., 1996)
Comments
Stocks ( 6 )
Bloomington	4040 C(1)DX, y¹ f¹/In(1)dl-49, w¹ lz^s
Kyoto	150179 w¹¹¹⁸ Df(1)ED6940 / In(1)dl-49, w¹ lz^s 107563 C(1)DX, y¹ f¹/In(1)dl-49, w¹ lz^s 102041 In(1)dl-49, l(1)1Ac⁴ y¹ w¹ lz^s f^36a / In(1)sc⁷ + In(1)AM 107749 In(1)dl-49, y¹ w¹ lz^s/In(1)sc^L8, sc^L8 w^a m² car¹ 101066 ClB, sc¹ l(1)C¹ t² v¹ sl¹ B¹ / FM1, y^31d sc⁸ w^a lz^s B¹
Notes on Origin
Discoverer	Patterson, 1928.

Comments
	lz^s maps to the spectacle sublocus of lz. (Batterham et al., 1996) lz^s/lz^g provided probably the first recorded case of intra-allelic recombination (Oliver, 1940a; Oliver, 1940b).
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	lz^s (Rizki et al., 1985) lz^S (Gajewski et al., 2007) lz^sp spe¹
Name Synonym	spectacle (Crew et al., 1997) spectacled
Secondary FlyBase IDs

References ( 23 )

Generate a list of	All references relating to this allele ( 23 )

List References by type	Research paper ( 17 ) Review ( 1 ) Personal communication to FlyBase ( 1 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Book ( 2 )
Recent research papers (0)
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Recent reviews (0)
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Allele Dmel\lzs

Allele Dmel\lz^s