Allele Dmel\lz^y4

General Information
Symbol	Dmel\lz^y4	Species	D. melanogaster
Name	in yellow-4	FlyBase ID	FBal0011836
Feature type	allele	Associated gene	Dmel\lz

Allele class
Mutagen	X ray
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	X ray (Green and Green, 1956)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deletion of 1bp causes a frame-shift in exon VI. (Jackson Behan et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	eye color defective eye color defective \| recessive (Green and Green, 1956) female sterile increased cell death (Siddall et al., 2003) visible (Siddall et al., 2003) visible \| recessive (Green and Green, 1956, Batterham et al., 1996) visible \| semidominant
Phenotype Manifest In
	eye (Green and Green, 1956, Siddall et al., 2003, Batterham et al., 1996, ) eye disc (Siddall et al., 2003) female accessory gland ommatidium (Batterham et al., 1996, ) ovary (Green and Green, 1956) pigment cell (Green and Green, 1956, ) sensillum basiconicum of antennal segment 3 (Stocker et al., 1993) sensillum trichodeum of antennal segment 3 (Stocker et al., 1993) spermathecum (Green and Green, 1956, ) third segment of antenna (Stocker et al., 1993) unguis (Green and Green, 1956)
Detailed Description
	Statement Reference lz^y4 adults have a "spectacle" eye phenotype. Ectopic cell death is seen in third larval instar eye discs. (Siddall et al., 2003) Homozygotes have a total lack of ommatidial structure in the eye. The eyes may have mottled pigmentation with black pock marks visible on the surface of the eye, or pigment may be dispersed as a ring around the edge of the eye ("spectacle" phenotype). (Batterham et al., 1996) Mutants display locomotor activity rhythms with circadian periods, though with reduced penetrance (small sample size). (Vosshall and Young, 1995) The antennal funiculus is reduced in size in hemizygous males. All large and small basiconic sensilla on the antennal funiculus are missing, and the number of trichoid sensilla on the antennal funiculus is reduced. The number of coeloconic sensilla on the antennal funiculus is normal. The density of the coeloconic and trichoid sensilla on the antennal funiculus is increased compared to wild-type. (Stocker et al., 1993) Eyes are greatly reduced in size and have a smooth surface in homozygous flies. Red eye pigment is sparse and confined primarily to the margin of the eye. Tarsal claws are vestigial. The spermathecae and pars ovariae are absent in homozygous females. (Green and Green, 1956) lz^y4/+ females have abnormal or absent female accessory glands and tend to lack spermathecae. (Anderson, 1945) RK1. spectacle; spermathecae absent; parovaria absent Eye colour: redder than lz^s. Similar to lz^s but eye color redder.
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	lz^50e (Batterham et al., 1996) lz^77a7 (Batterham et al., 1996)
Fails to complement	lz¹ (Batterham et al., 1996) lz³ (Batterham et al., 1996) lz³⁶ (Batterham et al., 1996) lz⁴⁶ (Batterham et al., 1996) lz^48f (Batterham et al., 1996) lz^86b (Batterham et al., 1996) lz¹¹⁴ (Gupta and Rodrigues, 1995) lz²¹⁶ (Gupta and Rodrigues, 1995) lz²³⁵ (Gupta and Rodrigues, 1995) lz^g (Batterham et al., 1996) lz^L (Batterham et al., 1996) lz^mr2 (Batterham et al., 1996) lz^pm1 (Batterham et al., 1996) lz^pm2 (Batterham et al., 1996)
Comments
Stocks ( 1 )
Bloomington	114 sn³ lz^y4 v¹/C(1)DX, y¹ f¹
Notes on Origin
Discoverer

Comments
	lz^y4 maps to the glossy sublocus of lz. (Batterham et al., 1996)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	lz^Y4 (Jackson Behan et al., 2005) lz^y4
Name Synonym	in yellow-4
Secondary FlyBase IDs

References ( 12 )
Research paper	Jackson Behan et al., 2005, Dev. Genes Evol. 215(8): 423--435 Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development. [FBrf0187438] Siddall et al., 2003, Dev. Genes Evol. 213(3): 107--119 Mutations in lozenge and D-Pax2 invoke ectopic patterned cell death in the developing Drosophila eye using distinct mechanisms. [FBrf0158867] Batterham et al., 1996, J. Neurogenet. 10(4): 193--220 Genetic analysis of the lozenge gene complex in Drosophila melanogaster: adult visual system phenotypes. [FBrf0090446] Gupta and Rodrigues, 1995, J. Neurogenet. 10(3): 137--151 Distinct mechanisms of action of the lozenge locus in Drosophila eye and antennal development are suggested by the analysis of dominant enhancers. [FBrf0090589] Vosshall and Young, 1995, Neuron 15(2): 345--360 Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells. [FBrf0083505] Stocker et al., 1993, J. Neurogenet. 9(1): 29--53 Analysis of the antennal phenotype in the Drosophila mutant lozenge. [FBrf0068701] Peeples et al., 1969, Biochem. Genet. 3: 563--569 Activity of phenol oxidases of puparium formation stage in development of nineteen lozenge mutants of Drosophila melanogaster. [FBrf0020249] Peeples et al., 1969, Genetics 62: 161--170 Comparative studies of phenol oxidase activity during pupal development of three lozenge mutants (lz⁸, lz, lz^k) of Drosophila melanogaster. [FBrf0020530] Green and Green, 1956, Z. indukt. Abstamm.- u. VererbLehre 87: 708--721 A cytogenetic analysis of the lozenge pseudoalleles in Drosophila melanogaster. [FBrf0011129] Oliver, 1947, Univ. Texas Publs 4720: 167--184 Interrelationship between eye color and facet arrangement in lozenge alleles of Drosophila melanogaster. [FBrf0006968] Anderson, 1945, Genetics 30: 280--296 A study of the factors affecting fertility of lozenge females of Drosophila melanogaster. [FBrf0006357]
Book	Lindsley and Grell, 1968, Publs Carnegie Instn 627: 469pp Genetic variations of Drosophila melanogaster. [FBrf0020044]

Allele Dmel\lzy4

Allele Dmel\lz^y4